Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia
暂无分享,去创建一个
Francine E. Garrett-Bakelman | M. Weirauch | A. Melnick | S. Kesari | Cem Meydan | Elmar Nurmemmedov | R. Kovall | J. Perentesis | S. Chutipongtanate | M. Wunderlich | J. Mulloy | D. Starczynowski | T. Muto | L. Bolanos | Kathleen Hueneman | Kwangmin Choi | B. Will | Laura Barreyro | W. Seibel | Madeline Niederkorn | Molly A Smith | Yaseswini Neelamraju | K. Greis | Z. Gul | A. Sampson | E. O'Brien | S. Christie | W. D. Haffey | M. Wyder | S. Medlin | C. Ishikawa | Mario Pujato | Boris A. Bartholdy | V. Ramesh | Ellen M Kolb | Kathleen M Hueneman | W. Haffey
[1] D. Starczynowski,et al. IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies , 2021, Current opinion in hematology.
[2] T. Haferlach,et al. Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. , 2021, Cell stem cell.
[3] D. Starczynowski,et al. Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS , 2021, The Journal of experimental medicine.
[4] C. Leslie,et al. Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets. , 2021, Cell stem cell.
[5] G. Garcia-Manero,et al. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs , 2020, Nature Immunology.
[6] F. Jiang,et al. Targeting AML-associated FLT3 mutations with a type I kinase inhibitor. , 2020, The Journal of clinical investigation.
[7] S. Kesari,et al. Cellular thermal shift analysis for interrogation of CRISPR-assisted proteomic changes. , 2020, BioTechniques.
[8] A. Wang,et al. Overcoming adaptive therapy resistance in AML by targeting immune response pathways , 2019, Science Translational Medicine.
[9] K. Pradhan,et al. U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies , 2019, Nature Cell Biology.
[10] Kwangmin Choi,et al. iGEAK: an interactive gene expression analysis kit for seamless workflow using the R/shiny platform , 2019, BMC Genomics.
[11] Minoru Kanehisa,et al. New approach for understanding genome variations in KEGG , 2018, Nucleic Acids Res..
[12] D. Starczynowski,et al. Chronic immune response dysregulation in MDS pathogenesis. , 2018, Blood.
[13] S. Chutipongtanate,et al. Multiplex Biomarker Screening Assay for Urinary Extracellular Vesicles Study: A Targeted Label-Free Proteomic Approach , 2018, Scientific Reports.
[14] S. Kesari,et al. Cellular target engagement: a new paradigm in drug discovery. , 2018, Future medicinal chemistry.
[15] M. Manjili,et al. IFN‐γ orchestrates tumor elimination, tumor dormancy, tumor escape, and progression , 2018, Journal of leukocyte biology.
[16] Samuel H. Payne,et al. Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes , 2018, Leukemia.
[17] W. Xiao,et al. Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-кB activation , 2018, Oncotarget.
[18] Erika J. Thompson,et al. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis , 2018, Proceedings of the National Academy of Sciences.
[19] N. Salomonis,et al. TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis , 2018, Cell reports.
[20] Cai-yun Zhou,et al. The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer , 2018, Cell Death & Disease.
[21] Yong Wang,et al. MicroRNA miR-147b promotes tumor growth via targeting UBE2N in hepatocellular carcinoma , 2017, Oncotarget.
[22] K. Gritsman,et al. Inflammatory Signaling Pathways in Preleukemic and Leukemic Stem Cells , 2017, Front. Oncol..
[23] Fei Xing,et al. Stromal cell extracellular vesicular cargo mediated regulation of breast cancer cell metastasis via ubiquitin conjugating enzyme E2 N pathway , 2017, Oncotarget.
[24] T. Nakano,et al. Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer. , 2017, Anticancer research.
[25] A. Verma,et al. Stem and progenitor cell alterations in myelodysplastic syndromes. , 2017, Blood.
[26] M. Weirauch,et al. Correction: Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia , 2017, Nature Immunology.
[27] D. Harki,et al. Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions. , 2017, Journal of medicinal chemistry.
[28] Eric S. Lander,et al. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras , 2017, Cell.
[29] J. Maciejewski,et al. Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome , 2017, Leukemia.
[30] M. Weirauch,et al. Ubiquitination of the spliceosome auxiliary factor hnRNPA1 by TRAF6 links chronic innate immune signaling with hematopoietic defects and myelodysplasia , 2016, Nature Immunology.
[31] Minoru Kanehisa,et al. KEGG: new perspectives on genomes, pathways, diseases and drugs , 2016, Nucleic Acids Res..
[32] J. Maciejewski,et al. Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome , 2017, Leukemia.
[33] M. Kimmel,et al. Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation. , 2016, Cell reports.
[34] R. Kanaar,et al. Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia. , 2016, Cell stem cell.
[35] John Calvin Reed,et al. Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity , 2016, Scientific Reports.
[36] J. Glover,et al. Ubc13: the Lys63 ubiquitin chain building machine , 2016, Oncotarget.
[37] John M. Ashton,et al. Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche. , 2016, Cell stem cell.
[38] K. Komurov,et al. A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes , 2016, Nature Medicine.
[39] L. Schuettpelz,et al. Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms , 2016, Blood Cancer Journal.
[40] E. Elinav,et al. Integration of Innate Immune Signaling. , 2016, Trends in immunology.
[41] Daniel Martinez Molina,et al. The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies. , 2016, Annual review of pharmacology and toxicology.
[42] Xingmin Feng,et al. IFN-γ-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure. , 2015, Blood.
[43] A. Karsan,et al. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signaling , 2015, The Journal of experimental medicine.
[44] T. Fioretos,et al. Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia , 2015, Proceedings of the National Academy of Sciences.
[45] D. Starczynowski,et al. Deconstructing innate immune signaling in myelodysplastic syndromes. , 2015, Experimental hematology.
[46] J. Glover,et al. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. , 2015, ACS chemical biology.
[47] Matthew E. Ritchie,et al. limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.
[48] D. Stainier,et al. Interferon gamma signaling positively regulates hematopoietic stem cell emergence. , 2014, Developmental cell.
[49] S. Orkin,et al. Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production , 2014, Genes & development.
[50] W. Huber,et al. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.
[51] G. Challen,et al. Type II Interferon Promotes Differentiation of Myeloid‐Biased Hematopoietic Stem Cells , 2014, Stem cells.
[52] J. Baell,et al. Chemistry: Chemical con artists foil drug discovery , 2014, Nature.
[53] Nicholas Borcherding,et al. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade , 2014, Proceedings of the National Academy of Sciences.
[54] G. Challen,et al. Type II Interferon Promotes Differentiation of Myeloid‐Biased Hematopoietic Stem Cells , 2014, Stem cells.
[55] Zhaojia Wu,et al. Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-кB mediated matrix metalloproteinase-1 gene regulation , 2014, Breast Cancer Research.
[56] G. Garcia-Manero,et al. An MDS xenograft model utilizing a patient-derived cell line , 2014, Leukemia.
[57] C. Schürch,et al. Cytotoxic CD8+ T cells stimulate hematopoietic progenitors by promoting cytokine release from bone marrow mesenchymal stromal cells. , 2014, Cell stem cell.
[58] J. Dou,et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways , 2014, Cell Death and Disease.
[59] Wei Shi,et al. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features , 2013, Bioinform..
[60] Lesley A. Mathews,et al. Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. , 2013, Cancer cell.
[61] P. Nordlund,et al. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay , 2013, Science.
[62] Alex S. Arvanitakis,et al. Selective killing of candidate AML stem cells by antibody targeting of IL1RAP. , 2013, Blood.
[63] Christoph H. Emmerich,et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system , 2013, The Biochemical journal.
[64] U. Steidl,et al. Concise Review: Preleukemic Stem Cells: Molecular Biology and Clinical Implications of the Precursors to Leukemia Stem Cells , 2013, Stem cells translational medicine.
[65] Thomas R. Gingeras,et al. STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..
[66] C. Steidl,et al. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. , 2012, Blood.
[67] Bronwen L. Aken,et al. GENCODE: The reference human genome annotation for The ENCODE Project , 2012, Genome research.
[68] I. Sanz,et al. Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. , 2012, Blood.
[69] S. Ben-Neriah,et al. Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. , 2012, Blood.
[70] G. Jansen,et al. Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. , 2012, Blood.
[71] Kevin W Eliceiri,et al. NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.
[72] S. Akira,et al. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells , 2012, Nature Immunology.
[73] R. Winqvist,et al. Mutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families , 2011, BMC Medical Genetics.
[74] L. Nie,et al. Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells , 2011, The Journal of Immunology.
[75] P. Karplus,et al. Cysteine-based Redox Switches in Enzymes , 2022 .
[76] Kyunghee Choi,et al. Infection-Induced Myelopoiesis during Intracellular Bacterial Infection Is Critically Dependent upon IFN-γ Signaling , 2011, The Journal of Immunology.
[77] Gary D Bader,et al. Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation , 2010, PloS one.
[78] M. Breccia,et al. NF-κB as a potential therapeutic target in myelodysplastic syndromes and acute myeloid leukemia , 2010, Expert opinion on therapeutic targets.
[79] Nathan C Boles,et al. Quiescent hematopoietic stem cells are activated by IFNγ in response to chronic infection , 2010, Nature.
[80] Y. Tohyama,et al. Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis , 2010, Leukemia.
[81] Colin N. Dewey,et al. RNA-Seq gene expression estimation with read mapping uncertainty , 2009, Bioinform..
[82] Hadley Wickham,et al. ggplot2 - Elegant Graphics for Data Analysis (2nd Edition) , 2017 .
[83] L. Genestier,et al. The TLR1/2 agonist PAM3CSK4 instructs commitment of human hematopoietic stem cells to a myeloid cell fate , 2009, Leukemia.
[84] T. Suda,et al. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–dependent exhaustion , 2009, Nature Medicine.
[85] Andreas Trumpp,et al. IFNα activates dormant haematopoietic stem cells in vivo , 2009, Nature.
[86] Pornpimol Charoentong,et al. ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks , 2009, Bioinform..
[87] Brad T. Sherman,et al. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.
[88] K. Glaser,et al. Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML. , 2007, Blood.
[89] C. Pascutto,et al. WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO). , 2008, Blood.
[90] R. Wilson,et al. Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. , 2008, Blood.
[91] R. Wilson,et al. Identification of somatic JAK 1 mutations in patients with acute myeloid leukemia , 2008 .
[92] Brad T. Sherman,et al. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.
[93] John Calvin Reed,et al. Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses , 2007, Proceedings of the National Academy of Sciences.
[94] M. Wadhwa,et al. Continuous delivery of human type I interferons (α/β) has significant activity against acute myeloid leukemia cells in vitro and in a xenograft model , 2007 .
[95] F. Lund-Johansen,et al. Signaling through toll-like receptor 7/8 induces the differentiation of human bone marrow CD34+ progenitor cells along the myeloid lineage. , 2006, Journal of molecular biology.
[96] Cynthia Wolberger,et al. Mms2–Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation , 2006, Nature Structural &Molecular Biology.
[97] Li Wang,et al. Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype. , 2006, Blood.
[98] Anne E Carpenter,et al. A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen , 2006, Cell.
[99] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[100] Xiao-hong Wang,et al. Sustained low-level expression of interferon-γ promotes tumor development: potential insights in tumor prevention and tumor immunotherapy , 2005, Cancer Immunology, Immunotherapy.
[101] P. Shannon,et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.
[102] W. Xiao,et al. Noncovalent Interaction between Ubiquitin and the Human DNA Repair Protein Mms2 Is Required for Ubc13-mediated Polyubiquitination* , 2001, The Journal of Biological Chemistry.
[103] M. Pfaffl,et al. A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.
[104] Susumu Goto,et al. KEGG: Kyoto Encyclopedia of Genes and Genomes , 2000, Nucleic Acids Res..