Innate Immunity and Inflammation in NAFLD/NASH

[1]  E. Bugianesi,et al.  Progression and Natural History of Nonalcoholic Fatty Liver Disease in Adults. , 2016, Clinics in liver disease.

[2]  L. Henry,et al.  Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in the United States and the Rest of the World. , 2016, Clinics in liver disease.

[3]  H. Metselaar,et al.  The invasion of fatty liver disease in liver transplantation , 2016, Transplant international : official journal of the European Society for Organ Transplantation.

[4]  E. Albano,et al.  The role of immune mechanisms in alcoholic and nonalcoholic steatohepatitis: a 2015 update , 2016, Expert review of gastroenterology & hepatology.

[5]  J. Godos,et al.  Targeting gut-liver axis for the treatment of nonalcoholic steatohepatitis: translational and clinical evidence. , 2016, Translational research : the journal of laboratory and clinical medicine.

[6]  M. E. Shaker,et al.  Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases. , 2015, Antioxidants & redox signaling.

[7]  Lili Sheng,et al.  Implications of microbiota and bile acid in liver injury and regeneration. , 2015, Journal of hepatology.

[8]  F. Tacke,et al.  CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis , 2015, Hepatology.

[9]  E. Albano,et al.  CX3CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis. , 2015, Clinical science.

[10]  H. Cortez‐Pinto,et al.  Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis. , 2015, Clinical science.

[11]  N. Lanthier.  Targeting Kupffer cells in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Why and how? , 2015, World journal of hepatology.

[12]  C. McClain,et al.  Gut-liver axis, nutrition, and non-alcoholic fatty liver disease. , 2015, Clinical biochemistry.

[13]  M. Arrese,et al.  Recent insights on the role of cholesterol in non-alcoholic fatty liver disease. , 2015, Biochimica et biophysica acta.

[14]  M. Uribe,et al.  The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease , 2015, BioMed research international.

[15]  A. Sanyal,et al.  Epidemiology and Natural History of Nonalcoholic Fatty Liver Disease , 2015, Seminars in Liver Disease.

[16]  E. Bjornsson,et al.  Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease. , 2015, Gastroenterology.

[17]  A. Burt,et al.  Diagnosis and Assessment of NAFLD: Definitions and Histopathological Classification , 2015, Seminars in Liver Disease.

[18]  L. Vonghia,et al.  Cross talk of the immune system in the adipose tissue and the liver in non-alcoholic steatohepatitis: Pathology and beyond. , 2015, World journal of hepatology.

[19]  G. Szabo,et al.  Inflammasome activation and function in liver disease , 2015, Nature Reviews Gastroenterology &Hepatology.

[20]  F. Higuera-De la Tijera,et al.  Pathophysiological mechanisms involved in non-alcoholic steatohepatitis and novel potential therapeutic targets. , 2015, World journal of hepatology.

[21]  C. Penha-Gonçalves,et al.  How Inflammation Impinges on NAFLD: A Role for Kupffer Cells , 2015, BioMed research international.

[22]  M. Arrese,et al.  Obeticholic acid: expanding the therapeutic landscape of NASH. , 2015, Annals of hepatology.

[23]  E. Albano,et al.  Fat-laden macrophages modulate lobular inflammation in nonalcoholic steatohepatitis (NASH). , 2015, Experimental and molecular pathology.

[24]  R. Schwabe,et al.  Hepatic inflammation and fibrosis: Functional links and key pathways , 2015, Hepatology.

[25]  K. Streetz,et al.  Immunoregulation by lipids during the development of non-alcoholic steatohepatitis. , 2015, Hepatobiliary surgery and nutrition.

[26]  M. Dave,et al.  Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability , 2015, Cellular and molecular gastroenterology and hepatology.

[27]  G. Gores,et al.  Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic Steatohepatitis , 2014, Cellular and molecular gastroenterology and hepatology.

[28]  C. Trautwein,et al.  Innate immune signaling and gut-liver interactions in non-alcoholic fatty liver disease. , 2014, Hepatobiliary surgery and nutrition.

[29]  Neil Kaplowitz,et al.  Cell death and cell death responses in liver disease: mechanisms and clinical relevance. , 2014, Gastroenterology.

[30]  M. Yeh,et al.  Pathological features of fatty liver disease. , 2014, Gastroenterology.

[31]  B. Staels,et al.  GFT505 for the treatment of nonalcoholic steatohepatitis and type 2 diabetes , 2014, Expert opinion on investigational drugs.

[32]  F. Tacke,et al.  Roles for chemokines in liver disease. , 2014, Gastroenterology.

[33]  Y. Kohgo,et al.  Augmented hepatic Toll‐like receptors by fatty acids trigger the pro‐inflammatory state of non‐alcoholic fatty liver disease in mice , 2014, Hepatology research : the official journal of the Japan Society of Hepatology.

[34]  F. Kuipers,et al.  Beyond intestinal soap—bile acids in metabolic control , 2014, Nature Reviews Endocrinology.

[35]  K. Uchida.  Natural antibodies as a sensor of electronegative damage-associated molecular patterns (DAMPs). , 2014, Free radical biology & medicine.

[36]  W. Mehal.  The Inflammasome in Liver Injury and Non-Alcoholic Fatty Liver Disease , 2014, Digestive Diseases.

[37]  A. Alisi,et al.  Intestinal permeability is increased in children with non-alcoholic fatty liver disease, and correlates with liver disease severity. , 2014, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[38]  A. Wree,et al.  NLRP3 inflammasome activation is required for fibrosis development in NAFLD , 2014, Journal of Molecular Medicine.

[39]  Frank Tacke,et al.  Macrophage heterogeneity in liver injury and fibrosis. , 2014, Journal of hepatology.

[40]  L. Powell,et al.  Evolving Concepts in the Pathogenesis of NASH: Beyond Steatosis and Inflammation , 2014, International journal of molecular sciences.

[41]  K. Irvine,et al.  The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease , 2014, Hepatology.

[42]  Zheng Zhang,et al.  The role of neutrophils in the development of liver diseases , 2014, Cellular and Molecular Immunology.

[43]  A. Wree,et al.  NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice , 2014, Hepatology.

[44]  J. Odin,et al.  Toll‐like receptors and liver disease , 2014, Liver international : official journal of the International Association for the Study of the Liver.

[45]  J. Friedman,et al.  Mice Lacking Natural Killer T Cells Are More Susceptible to Metabolic Alterations following High Fat Diet Feeding , 2014, PloS one.

[46]  Albert Tran,et al.  M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease , 2014, Hepatology.

[47]  D. Schuppan,et al.  Dendritic cells in liver injury and fibrosis: shortcomings and promises. , 2013, Journal of hepatology.

[48]  R. Ibusuki,et al.  Transgenic expression of human neutrophil peptide‐1 enhances hepatic fibrosis in mice fed a choline‐deficient, L‐amino acid–defined diet , 2013, Liver international : official journal of the International Association for the Study of the Liver.

[49]  G. Bánhegyi,et al.  Lipotoxicity in the liver. , 2013, World journal of hepatology.

[50]  Vipin Kumar.  NKT-cell subsets: promoters and protectors in inflammatory liver disease. , 2013, Journal of hepatology.

[51]  G. Szabo,et al.  Immune and inflammatory pathways in NASH , 2013, Hepatology International.

[52]  A. Rehman,et al.  Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice , 2013, Hepatology.

[53]  F. Tacke,et al.  From NAFLD to NASH to fibrosis to HCC: Role of dendritic cell populations in the liver , 2013, Hepatology.

[54]  F. Chan,et al.  RIP3: a molecular switch for necrosis and inflammation. , 2013, Genes & development.

[55]  P. Vajro,et al.  Microbiota and Gut–Liver Axis: Their Influences on Obesity and Obesity-Related Liver Disease , 2013, Journal of pediatric gastroenterology and nutrition.

[56]  Laura J. Dixon,et al.  Kupffer cells in the liver. , 2013, Comprehensive Physiology.

[57]  Z. Tian,et al.  Natural killer cells in liver disease , 2013, Hepatology.

[58]  D. Brenner,et al.  Toll‐like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice , 2013, Hepatology.

[59]  G. Szabo,et al.  Toll-like receptors in liver disease. , 2013, Advances in clinical chemistry.

[60]  S. Xanthoulea,et al.  Neutrophil-Derived Myeloperoxidase Aggravates Non-Alcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Deficient Mice , 2012, PloS one.

[61]  P. Kubes,et al.  Sterile inflammation in the liver. , 2012, Gastroenterology.

[62]  H. Tilg,et al.  Adiponectin: key player in the adipose tissue-liver crosstalk. , 2012, Current medicinal chemistry.

[63]  J. Bressan,et al.  Potential mechanisms for the emerging link between obesity and increased intestinal permeability. , 2012, Nutrition research.

[64]  S. Makhzami,et al.  Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. , 2012, Journal of hepatology.

[65]  K. Tajiri,et al.  Role of NKT Cells in the Pathogenesis of NAFLD , 2012, International journal of hepatology.

[66]  J. Heimbach,et al.  Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. , 2011, Gastroenterology.

[67]  B. Staels,et al.  Macrophage polarization in metabolic disorders: functions and regulation , 2011, Current opinion in lipidology.

[68]  G. Gores,et al.  Mechanisms of Lipotoxicity in NAFLD and Clinical Implications , 2011, Journal of pediatric gastroenterology and nutrition.

[69]  D. Freese,et al.  A 3-year-old with immunoglobulin G4-associated cholangitis. , 2011, Journal of pediatric gastroenterology and nutrition.

[70]  A. Feldstein,et al.  Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications , 2011, Expert review of gastroenterology & hepatology.

[71]  M. Netea,et al.  Immunodeficiency and genetic defects of pattern-recognition receptors. , 2011, The New England journal of medicine.

[72]  A. Feldstein,et al.  Novel Insights into the Pathophysiology of Nonalcoholic Fatty Liver Disease , 2010, Seminars in liver disease.

[73]  D. Brenner,et al.  Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. , 2010, Gastroenterology.

[74]  G. Karaca,et al.  Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease , 2010, Hepatology.

[75]  H. Ellingsgaard,et al.  Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet , 2010, Diabetologia.

[76]  S. Akira,et al.  Pattern Recognition Receptors and Inflammation , 2010, Cell.

[77]  M. Trauner,et al.  Fatty liver and lipotoxicity. , 2010, Biochimica et biophysica acta.

[78]  R. Rippe,et al.  Kupffer cell and interleukin‐12–dependent loss of natural killer T cells in hepatosteatosis , 2010, Hepatology.

[79]  S. Hogan,et al.  Intestinal barrier function: molecular regulation and disease pathogenesis. , 2009, The Journal of allergy and clinical immunology.

[80]  K. Tsuneyama,et al.  Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease , 2009, European journal of gastroenterology & hepatology.

[81]  G. La Torre,et al.  Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease , 2009, Hepatology.

[82]  D. Brenner,et al.  Toll‐like receptors and adaptor molecules in liver disease: Update , 2008, Hepatology.

[83]  J. Fallowfield,et al.  Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis1 , 2007, The Journal of Immunology.

[84]  E. Elinav,et al.  Adoptive transfer of regulatory NKT lymphocytes ameliorates non‐alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trapping , 2006, The Journal of pathology.

[85]  Mitchell Kronenberg,et al.  Intravascular Immune Surveillance by CXCR6+ NKT Cells Patrolling Liver Sinusoids , 2005, PLoS biology.

[86]  G. Gores,et al.  Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. , 2003, Gastroenterology.