Learning from errors: analysis of medication order voiding in CPOE systems

Objective Medication order voiding allows clinicians to indicate that an existing order was placed in error. We explored whether the order voiding function could be used to record and study medication ordering errors. Materials and Methods We examined medication orders from an academic medical center for a 6-year period (2006-2011; n  = 5 804 150). We categorized orders based on status (void, not void) and clinician-provided reasons for voiding. We used multivariable logistic regression to investigate the association between order voiding and clinician, patient, and order characteristics. We conducted chart reviews on a random sample of voided orders ( n  = 198) to investigate the rate of medication ordering errors among voided orders, and the accuracy of clinician-provided reasons for voiding. Results We found that 0.49% of all orders were voided. Order voiding was associated with clinician type (physician, pharmacist, nurse, student, other) and order type (inpatient, prescription, home medications by history). An estimated 70 ± 10% of voided orders were due to medication ordering errors. Clinician-provided reasons for voiding were reasonably predictive of the actual cause of error for duplicate orders (72%), but not for other reasons. Discussion and Conclusion Medication safety initiatives require availability of error data to create repositories for learning and training. The voiding function is available in several electronic health record systems, so order voiding could provide a low-effort mechanism for self-reporting of medication ordering errors. Additional clinician training could help increase the quality of such reporting.

[1]  Qoua L. Her,et al.  The frequency of inappropriate nonformulary medication alert overrides in the inpatient setting , 2016, J. Am. Medical Informatics Assoc..

[2]  Katherine A. Sward,et al.  Impact of computerized provider order entry (CPOE) on length of stay and mortality , 2016, J. Am. Medical Informatics Assoc..

[3]  L. Cordero,et al.  Impact of Computerized Physician Order Entry on Clinical Practice in a Newborn Intensive Care Unit , 2004, Journal of Perinatology.

[4]  T. Brennan,et al.  Incidence of adverse events and negligence in hospitalized patients. , 1991, The New England journal of medicine.

[5]  Edward H Shortliffe,et al.  Role of cognition in generating and mitigating clinical errors , 2015, BMJ Quality & Safety.

[6]  Min Joung Kim,et al.  Effectiveness of a multidisciplinary critical pathway based on a computerised physician order entry system for ST-segment elevation myocardial infarction management in the emergency department: a retrospective observational study , 2016, BMJ Open.

[7]  D. Bates,et al.  Effects of computerized physician order entry and clinical decision support systems on medication safety: a systematic review. , 2003, Archives of internal medicine.

[8]  T A Brennan,et al.  Relation between negligent adverse events and the outcomes of medical-malpractice litigation. , 1996, The New England journal of medicine.

[9]  B. Franklin,et al.  Comment on ’Prevalence, Incidence and Nature of Prescribing Errors in Hospital Inpatients: A Systematic Review’ , 2010, Drug safety.

[10]  Matthew Burns,et al.  Indication-based prescribing prevents wrong-patient medication errors in computerized provider order entry (CPOE) , 2013, J. Am. Medical Informatics Assoc..

[11]  Jeffrey M. Weiss,et al.  Understanding and preventing wrong-patient electronic orders: a randomized controlled trial , 2013, J. Am. Medical Informatics Assoc..

[12]  David W. Bates,et al.  Clinical decision support systems could be modified to reduce 'alert fatigue' while still minimizing the risk of litigation. , 2011, Health affairs.

[13]  Itiel Dror,et al.  A cognitive perspective on technology enhanced learning in medical training: Great opportunities, pitfalls and challenges , 2011, Medical teacher.

[14]  Mark Spranca,et al.  Reduction in medication errors in hospitals due to adoption of computerized provider order entry systems , 2013, J. Am. Medical Informatics Assoc..

[15]  Ling Li,et al.  The safety of electronic prescribing: manifestations, mechanisms, and rates of system-related errors associated with two commercial systems in hospitals , 2013, J. Am. Medical Informatics Assoc..

[16]  Naonori Kodate,et al.  Can incident reporting improve safety? Healthcare practitioners' views of the effectiveness of incident reporting. , 2013, International journal for quality in health care : journal of the International Society for Quality in Health Care.

[17]  Bryony Dean Franklin,et al.  The Incidence of Prescribing Errors in Hospital Inpatients , 2005, Drug safety.

[18]  A. Localio,et al.  Role of computerized physician order entry systems in facilitating medication errors. , 2005, JAMA.

[19]  A. Potts,et al.  Computerized physician order entry and medication errors in a pediatric critical care unit. , 2004, Pediatrics.

[20]  R Khajouei,et al.  The Impact of CPOE Medication Systems’ Design Aspects on Usability, Workflow and Medication Orders , 2010, Methods of Information in Medicine.

[21]  D. Bates,et al.  Effect of computerized physician order entry and a team intervention on prevention of serious medication errors. , 1998, JAMA.

[22]  G. Kuperman,et al.  Computer Physician Order Entry: Benefits, Costs, and Issues , 2003, Annals of Internal Medicine.

[23]  Mary G. Amato,et al.  The vulnerabilities of computerized physician order entry systems: a qualitative study , 2016, J. Am. Medical Informatics Assoc..

[24]  B. Franklin,et al.  The effects of electronic prescribing on the quality of prescribing. , 2008, British journal of clinical pharmacology.

[25]  H Pohl,et al.  Medication prescribing errors in a teaching hospital. , 1990, JAMA.

[26]  Mary Etta Mills,et al.  Evaluating the Safety and Efficiency of a CPOE System for Continuous Medication Infusions in a Pediatric ICU , 2006, AMIA.

[27]  J. E. Groves,et al.  Made in America: Science, Technology and American Modernist Poets , 1989 .

[28]  Gordon D. Schiff,et al.  Indication Alerts Intercept Drug Name Confusion Errors during Computerized Entry of Medication Orders , 2014, PloS one.

[29]  T. Brennan,et al.  INCIDENCE OF ADVERSE EVENTS AND NEGLIGENCE IN HOSPITALIZED PATIENTS , 2008 .

[30]  D. L. Simms,et al.  Normal Accidents: Living with High-Risk Technologies , 1986 .

[31]  J. van Loon Network , 2006 .

[32]  K. McDonald,et al.  Making health care safer: a critical analysis of patient safety practices. , 2001, Evidence report/technology assessment.

[33]  L. Casalino,et al.  Paid malpractice claims for adverse events in inpatient and outpatient settings. , 2011, JAMA.

[34]  Gilad J. Kuperman,et al.  Case Report: Comprehensive Analysis of a Medication Dosing Error Related to CPOE , 2005, J. Am. Medical Informatics Assoc..

[35]  D W Bates,et al.  Computerised physician order entry-related medication errors: analysis of reported errors and vulnerability testing of current systems , 2002, BMJ Quality & Safety.

[36]  A. Fayaz-Bakhsh,et al.  The impact of computerized physician order entry on medication error prevention , 2014, International Journal of Clinical Pharmacy.