Tandem Analysis by a Dual-Trap Miniature Mass Spectrometer.

Miniature mass spectrometers are of an increasing interest for in-situ analyses, and their coupling with the ambient ionization sources is a valid path for direct analysis of complex samples. In this study, a miniature mass spectrometer using discontinuous atmospheric pressure interface was developed with a dual-LIT (linear ion trap) configuration. The comprehensive scan modes were enabled for tandem mass spectrometry analysis, which are critical for high-quality qualitative and quantitative analysis. A real-time pressure control was implemented to facilitate the ion transfer and collision induced dissociation (CID). Beam-type CID could be performed for tandem analysis at a high number of stages. In-trap CID at high q could also be performed with the fragment ions accumulated in a second trap. A precursor ion scan mode for analyzing target analytes has also been demonstrated.

[1]  D. J. Douglas.  Linear quadrupoles in mass spectrometry. , 2009, Mass spectrometry reviews.

[2]  Matthew A Kirleis,et al.  Autonomous in situ analysis and real-time chemical detection using a backpack miniature mass spectrometer: concept, instrumentation development, and performance. , 2014, Analytical chemistry.

[3]  R. Cooks,et al.  Ambient Mass Spectrometry , 2006, Science.

[4]  J. Ramsey,et al.  High Pressure Mass Spectrometry: The Generation of Mass Spectra at Operating Pressures Exceeding 1 Torr in a Microscale Cylindrical Ion Trap. , 2016, Analytical chemistry.

[5]  W. Xu,et al.  Study of Discontinuous Atmospheric Pressure Interfaces for Mass Spectrometry Instrumentation Development. , 2010, Analytical chemistry.

[6]  Phillip M. Mach,et al.  A portable mass spectrometer study targeting anthropogenic contaminants in Sub-Antarctic Puerto Williams, Chile , 2017 .

[7]  Qingyu Song,et al.  Handheld rectilinear ion trap mass spectrometer. , 2006, Analytical chemistry.

[8]  Zheng Ouyang,et al.  Miniature mass spectrometers. , 2009, Annual review of analytical chemistry.

[9]  Zheng Ouyang,et al.  Breaking the pumping speed barrier in mass spectrometry: discontinuous atmospheric pressure interface. , 2008, Analytical chemistry.

[10]  Z. Ouyang,et al.  Direct mass spectrometry analysis of biofluid samples using slug-flow microextraction nano-electrospray ionization. , 2014, Angewandte Chemie.

[11]  Wei Xu,et al.  Direct Biological Sample Analyses by Laserspray Ionization Miniature Mass Spectrometry. , 2018, Analytical chemistry.

[12]  J. Durup,et al.  Effect of charge exchange reactions on the motion of ions in three-dimensional quadrupole electric fields , 1976 .

[13]  R. March.  Quadrupole ion traps. , 2009, Mass spectrometry reviews.

[14]  Yu Xia,et al.  Linkage Determination of Linear Oligosaccharides by MSn (n > 2) Collision-Induced Dissociation of Z1 Ions in the Negative Ion Mode , 2014, Journal of The American Society for Mass Spectrometry.

[15]  R. Cooks,et al.  Enabling quantitative analysis in ambient ionization mass spectrometry: internal standard coated capillary samplers. , 2013, Analytical chemistry.

[16]  Yu Xia,et al.  Bidirectional ion transfer between quadrupole arrays: MSn ion/ion reaction experiments on a quadrupole/time-of-flight tandem mass spectrometer. , 2007, Analytical chemistry.

[17]  W. Xu,et al.  Mass selective ion transfer and accumulation in ion trap arrays. , 2014, Analytical chemistry.

[18]  L. Leuthold,et al.  Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules. , 2004, Journal of mass spectrometry : JMS.

[19]  Nicholas E. Manicke,et al.  Development of a Paper Spray Mass Spectrometry Cartridge with Integrated Solid Phase Extraction for Bioanalysis. , 2015, Analytical chemistry.

[20]  Z. Ouyang,et al.  Simulation of Rarefied Gas Flows in Atmospheric Pressure Interfaces for Mass Spectrometry Systems , 2013, Journal of The American Society for Mass Spectrometry.

[21]  Wei Xu,et al.  Mini Mass Spectrometer Integrated with a Miniature Ion Funnel. , 2017, Analytical chemistry.

[22]  Zheng Ouyang,et al.  Low-temperature plasma probe for ambient desorption ionization. , 2008, Analytical chemistry.

[23]  R. Yost,et al.  Triple quadrupole mass spectrometry for direct mixture analysis and structure elucidation. , 1979, Analytical chemistry.

[24]  G. Glish,et al.  High amplitude short time excitation: A method to form and detect low mass product ions in a quadrupole ion trap mass spectrometer , 2006, Journal of the American Society for Mass Spectrometry.

[25]  R. Syms,et al.  A microelectromechanical systems-enabled, miniature triple quadrupole mass spectrometer. , 2015, Analytical chemistry.

[26]  R. Cooks,et al.  Implementation of Precursor and Neutral Loss Scans on a Miniature Ion Trap Mass Spectrometer and Performance Comparison to a Benchtop Linear Ion Trap , 2018, Journal of The American Society for Mass Spectrometry.

[27]  K. Mueller,et al.  Airborne Single Particle Mass Spectrometers (SPLAT II & miniSPLAT) and New Software for Data Visualization and Analysis in a Geo-Spatial Context , 2015, Journal of The American Society for Mass Spectrometry.

[28]  Z. Ouyang,et al.  Direct Analysis of Nonvolatile Chemical Compounds on Surfaces Using a Hand-Held Mass Spectrometer with Synchronized Discharge Ionization Function. , 2016, Analytical chemistry.

[29]  R. Byrne,et al.  Field-deployed underwater mass spectrometers for investigations of transient chemical systems. , 2004, Talanta.

[30]  R. Cooks,et al.  Ion isolation and multigenerational collision-induced dissociation using the inverse Mathieu q scan. , 2017, Rapid communications in mass spectrometry : RCM.

[31]  Jentaie Shiea,et al.  Ambient ionization mass spectrometry. , 2010, Annual review of analytical chemistry.

[32]  R. Cooks,et al.  Real-time sample analysis using a sampling probe and miniature mass spectrometer. , 2015, Analytical chemistry.

[33]  R. March,et al.  The effects of charge exchange collisions on the motion of ions in three-dimensional quadrupole electric fields Part II. Program improvements and fundamental results , 1977 .

[34]  Z. Ouyang,et al.  Paper-capillary spray for direct mass spectrometry analysis of biofluid samples , 2016, Analytical and Bioanalytical Chemistry.

[35]  Z. Ouyang,et al.  Direct Mass Spectrometry Analysis of Untreated Samples of Ultralow Amounts Using Extraction Nano-Electrospray. , 2013, Analytical methods : advancing methods and applications.

[36]  Z. Ouyang,et al.  Ambient ionization and miniature mass spectrometry system for chemical and biological analysis. , 2016, Trends in analytical chemistry : TRAC.

[37]  Zheng Ouyang,et al.  Paper spray for direct analysis of complex mixtures using mass spectrometry. , 2010, Angewandte Chemie.

[38]  Z. Ouyang,et al.  Ambient Ionization and Miniature Mass Spectrometry Systems for Disease Diagnosis and Therapeutic Monitoring , 2017, Theranostics.

[39]  James W. Hager,et al.  A new linear ion trap mass spectrometer , 2002 .

[40]  Zheng Ouyang,et al.  Mini 12, Miniature Mass Spectrometer for Clinical and Other Applications—Introduction and Characterization , 2014, Analytical chemistry.

[41]  Yu Xia,et al.  Assignment of the Stereochemistry and Anomeric Configuration of Sugars within Oligosaccharides Via Overlapping Disaccharide Ladders Using MSn , 2014, Journal of The American Society for Mass Spectrometry.

[42]  Fred Goesmann,et al.  Detection of trace organics in Mars analog samples containing perchlorate by laser desorption/ionization mass spectrometry. , 2015, Astrobiology.

[43]  Z. Ouyang,et al.  Following the Ions through a Mass Spectrometer with Atmospheric Pressure Interface: Simulation of Complete Ion Trajectories from Ion Source to Mass Analyzer. , 2016, Analytical chemistry.

[44]  J. Hager,et al.  Product ion scanning using a Q-q-Q linear ion trap (Q TRAP) mass spectrometer. , 2003, Rapid communications in mass spectrometry : RCM.

[45]  Xianlin Han,et al.  Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. , 2005, Mass spectrometry reviews.

[46]  Jixin Liu,et al.  Evaluation of a hydride generation-atomic fluorescence system for the determination of arsenic using a dielectric barrier discharge atomizer. , 2008, Analytica chimica acta.

[47]  John Robert Brucato,et al.  The Mars Organic Molecule Analyzer (MOMA) Instrument: Characterization of Organic Material in Martian Sediments , 2017, Astrobiology.

[48]  Prabha Dwivedi,et al.  Mass spectrometry: recent advances in direct open air surface sampling/ionization. , 2013, Chemical reviews.

[49]  D. J. Douglas,et al.  Linear ion traps in mass spectrometry. , 2005, Mass spectrometry reviews.

[50]  Zheng Ouyang,et al.  Design of Portable Mass Spectrometers with Handheld Probes: Aspects of the Sampling and Miniature Pumping Systems , 2015, Journal of The American Society for Mass Spectrometry.

[51]  R. Cooks,et al.  Miniature and Fieldable Mass Spectrometers: Recent Advances. , 2016, Analytical chemistry.