In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy

[1]  K. Clarke,et al.  In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart. , 2012, Cardiovascular research.

[2]  Kieran Clarke,et al.  Hyperpolarized Magnetic Resonance: A Novel Technique for the In Vivo Assessment of Cardiovascular Disease , 2011, Circulation.

[3]  Neil Clarke,et al.  Dynamic nuclear polarization polarizer for sterile use intent , 2011, NMR in biomedicine.

[4]  Luigi Atzori,et al.  Metabolomics as a tool for cardiac research , 2011, Nature Reviews Cardiology.

[5]  S. Denis,et al.  Fasting-Induced Myocardial Lipid Accumulation in Long-Chain Acyl-CoA Dehydrogenase Knockout Mice Is Accompanied by Impaired Left Ventricular Function , 2011, Circulation. Cardiovascular imaging.

[6]  G. Radda,et al.  Role of Pyruvate Dehydrogenase Inhibition in the Development of Hypertrophy in the Hyperthyroid Rat Heart: A Combined Magnetic Resonance Imaging and Hyperpolarized Magnetic Resonance Spectroscopy Study , 2011, Circulation.

[7]  J. Tardif,et al.  Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts. , 2011, American journal of physiology. Heart and circulatory physiology.

[8]  G. Radda,et al.  Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS , 2011, NMR in biomedicine.

[9]  D. Tyler,et al.  Cardiovascular Applications of Hyperpolarized MRI , 2011, Current cardiovascular imaging reports.

[10]  F. Gallagher,et al.  Detection of Tumor Response to a Vascular Disrupting Agent by Hyperpolarized 13C Magnetic Resonance Spectroscopy , 2010, Molecular Cancer Therapeutics.

[11]  Graham A Wright,et al.  Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart , 2010, Magnetic resonance in medicine.

[12]  G. Radda,et al.  Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study , 2009, Cardiovascular research.

[13]  T. Warner,et al.  The Epoxygenases CYP2J2 Activates the Nuclear Receptor PPARα In Vitro and In Vivo , 2009, PloS one.

[14]  Ferdia A Gallagher,et al.  A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment. , 2009, Neoplasia.

[15]  G. Radda,et al.  In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance , 2008, Proceedings of the National Academy of Sciences.

[16]  D. Wasserman,et al.  Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains , 2008, Diabetes.

[17]  Craig R. Malloy,et al.  Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR , 2007, Proceedings of the National Academy of Sciences.

[18]  Jan Wolber,et al.  Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy , 2007, Nature Medicine.

[19]  T. Pineau,et al.  Role of oxidative stress in cardiac dysfunction of PPARα−/− mice , 2007 .

[20]  E. Abel,et al.  Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity , 2005, Circulation.

[21]  Kieran Clarke,et al.  A Functional Analysis of Mouse Models of Cardiac Disease through Metabolic Profiling* , 2005, Journal of Biological Chemistry.

[22]  C. Des Rosiers,et al.  Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts to an adrenergic stress: benefits of a medium-chain fatty acid. , 2005, American journal of physiology. Heart and circulatory physiology.

[23]  Wesley E. Martin,et al.  Surfactant Protein A Binds Mycoplasma pneumoniae with High Affinity and Attenuates Its Growth by Recognition of Disaturated Phosphatidylglycerols* , 2005, Journal of Biological Chemistry.

[24]  M. Holness,et al.  Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. , 2003, Biochemical Society transactions.

[25]  Kieran Clarke,et al.  Fast, high‐resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system , 2003, Journal of magnetic resonance imaging : JMRI.

[26]  Jan H. Ardenkjær-Larsen,et al.  Molecular imaging with endogenous substances , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[27]  J. Ardenkjær-Larsen,et al.  Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[28]  Mohit M. Jain,et al.  Cardiac-Specific Overexpression of GLUT1 Prevents the Development of Heart Failure Attributable to Pressure Overload in Mice , 2002, Circulation.

[29]  W. Kraus,et al.  Fatty Acid Homeostasis and Induction of Lipid Regulatory Genes in Skeletal Muscles of Peroxisome Proliferator-activated Receptor (PPAR) α Knock-out Mice , 2002, The Journal of Biological Chemistry.

[30]  Robert A. Harris,et al.  Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin. , 2002, Diabetes.

[31]  R. de Beer,et al.  Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals , 2001, Comput. Biol. Medicine.

[32]  I. Wilson,et al.  An NMR‐based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse , 2000, FEBS letters.

[33]  D. Kelly,et al.  A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[34]  D. Kurtz,et al.  Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[35]  B. Thrall,et al.  Effects of dichloroacetate on glycogen metabolism in B6C3F1 mice. , 1998, Toxicology.

[36]  H Y Kim,et al.  Liquid chromatography/mass spectrometry of phospholipids using electrospray ionization. , 1994, Analytical chemistry.

[37]  S. Wolfensohn,et al.  Handbook of Laboratory Animal Management and Welfare , 1994 .

[38]  R S Balaban,et al.  Pyruvate and lactate metabolism in the in vivo dog heart. , 1993, The American journal of physiology.

[39]  R. Shulman,et al.  In vivo carbon-13 nuclear magnetic resonance studies of heart metabolism. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[40]  J C Stanley,et al.  The glucose-fatty acid cycle. Relationship between glucose utilization in muscle, fatty acid oxidation in muscle and lipolysis in adipose tissue. , 1981, British journal of anaesthesia.

[41]  P. J. Randle,et al.  Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids. , 1974, The Biochemical journal.

[42]  E. Newsholme,et al.  The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. , 1963, Lancet.

[43]  A. Beckman,et al.  A Quartz Photoelectric Spectrophotometer , 1941 .

[44]  A. Khera,et al.  Clinical characteristics, vascular function, and inflammation in women with angina in the absence of coronary atherosclerosis: the Dallas Heart Study. , 2011, JACC. Cardiovascular imaging.

[45]  Ilwoo Park,et al.  Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice. , 2010, Journal of magnetic resonance.

[46]  T. Pineau,et al.  Role of oxidative stress in cardiac dysfunction of PPARalpha-/- mice. , 2007, American journal of physiology. Heart and circulatory physiology.

[47]  Kieran Clarke,et al.  CINE-MR imaging of the normal and infarcted rat heart using an 11.7 T vertical bore MR system. , 2006, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[48]  T. Meyer,et al.  Impact of genetic background on nephropathy in diabetic mice. , 2006, American journal of physiology. Renal physiology.

[49]  J S Petersson,et al.  Molecular imaging using hyperpolarized 13C. , 2003, The British journal of radiology.

[50]  Leone,et al.  A critical role for the peroxisome proliferator-activated receptor a (PPAR a ) in the cellular fasting response: The PPAR a -null mouse as a model of fatty acid oxidation disorders , 1999 .

[51]  K. M. Popov,et al.  Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. , 1998, The Biochemical journal.

[52]  K. M. Popov,et al.  Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. , 1998, The Biochemical journal.

[53]  D. L. Wilson,et al.  C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis. , 1998, Atherosclerosis.