Scalp-recorded oscillatory potentials evoked by transient pattern-reversal visual stimulation in man.

Replicable oscillatory potentials, time-locked to pattern stimuli (9.0 degrees central; counterphase reversal at 2.13 Hz) were dissociated from conventional, broad-band VEPs recorded in healthy volunteers at occipital scalp locations by high-pass digital filtering at 17.0-20.0 Hz. Nine consecutive wavelets were identified with a 56.4 +/- 8.4 msec mean latency of the first replicable wavelet and mean peak-to-peak amplitude varying between 0.9 and 2.0 muV. The first 2 wavelets had significantly shorter latencies than wave N70 of unfiltered VEP, whereas the last 2 wavelets had longer latencies than N145. Latency and amplitude values varied as a function of contrast and spatial frequency of the stimulus, with shorter latencies and larger amplitudes at 60-90% contrast level and tuning of amplitude at 5.0 c/deg. All wavelets were correlated with wave P100 of unfiltered VEP, while a correlation with N70 of VEP was observed only for those wavelets with latencies in the range of wave P100. Two patients with documented brain lesions involving the visual system are described as examples of oscillatory responses occurring irrespective of filter bandpass and instead of the expected conventional VEP when the generation of these is interfered with by brain pathology. A substantial cortical contribution to the origin of the oscillatory response is conceivable. It is suggested that the oscillatory response to pattern-reversal stimulation reflects events in the visual system that are parallel to, and partly independent of, the conventional VEP, with potential application in research or for clinical purposes.

[1]  S. Whittaker,et al.  Origin of wavelets in the visual evoked potential. , 1983, Electroencephalography and clinical neurophysiology.

[2]  C. Gray,et al.  Visually evoked oscillations of membrane potential in cells of cat visual cortex. , 1992, Science.

[3]  V. Torre,et al.  The responses of amacrine cells to light and intracellularly applied currents. , 1978, The Journal of physiology.

[4]  W. Carroll,et al.  Improvements in the accuracy of pattern visual evoked potentials in the diagnosis of visual pathway disease , 1982 .

[5]  F Fazekas,et al.  Cerebral metabolism and patterned visual Stimulation , 1988, Neurology.

[6]  B. Connors,et al.  Intrinsic firing patterns of diverse neocortical neurons , 1990, Trends in Neurosciences.

[7]  G. Harding,et al.  The scalp topography of the human visually evoked subcortical potential. , 1980, Investigative ophthalmology & visual science.

[8]  Robert Galambos,et al.  A Comparison of Certain Gamma Band (40-HZ) Brain Rhythms in Cat and Man , 1992 .

[9]  W. Singer.  Synchronization of cortical activity and its putative role in information processing and learning. , 1993, Annual review of physiology.

[10]  J P Joseph,et al.  Modifications of the pattern-evoked potential (PEP) in relation to the stimulated part of the visual field (clues for the most probable origin of each component). , 1979, Electroencephalography and clinical neurophysiology.

[11]  H Spekreijse,et al.  The extrastriate generators of the EP to checkerboard onset. A source localization approach. , 1991, Electroencephalography and clinical neurophysiology.

[12]  Meredith C. Phelps,et al.  Metabolic mapping of the brain's response to visual stimulation: studies in humans , 1981 .

[13]  R. H. Steinberg,et al.  Proximal retinal contribution to the intraretinal 8-Hz pattern ERG of cat. , 1987, Journal of neurophysiology.

[14]  C. Schroeder,et al.  Subcortical contributions to the surface-recorded flash-VEP in the awake macaque. , 1992, Electroencephalography and clinical neurophysiology.

[15]  W. Singer,et al.  Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus properties , 1989, Nature.

[16]  Y. Kuroiwa,et al.  Visual function of the extrageniculo-calcarine system in man: relationship to cortical blindness. , 1980, Archives of neurology.

[17]  J. Siegfried,et al.  Early wavelets in the VECP. , 1981, Investigative ophthalmology & visual science.

[18]  L. Wachtmeister.  FURTHER STUDIES OF THE CHEMICAL SENSITIVITY OF THE OSCILLATORY POTENTIALS OF THE ELECTRORETINOGRAM (ERG) , 1980 .

[19]  M. R. Harter,et al.  Evoked cortical responses to checkerboard patterns: effect of check-size as a function of retinal eccentricity. , 1970, Vision research.

[20]  C. Schroeder,et al.  Striate cortical contribution to the surface-recorded pattern-reversal vep in the alert monkey , 1991, Vision Research.

[21]  J. Kelsey,et al.  Visual Evoked Potentials in Man: New Developments , 1978 .

[22]  M Korth.  Luminosity functions of human electroretinogram wavelets evoked with pattern-reversal stimuli. , 1980, Investigative ophthalmology & visual science.

[23]  M. Kraut,et al.  Intracortical generators of the flash VEP in monkeys. , 1985, Electroencephalography and clinical neurophysiology.

[24]  G G Celesia,et al.  Effect of spatial frequency on simultaneous recorded steady-state pattern electroretinograms and visual evoked potentials. , 1991, Electroencephalography and clinical neurophysiology.

[25]  C. E. Schroeder,et al.  Timing and distribution of flash-evoked activity in the lateral geniculate nucleus of the alert monkey , 1989, Brain Research.

[26]  W. Singer,et al.  Temporal coding in the visual cortex: new vistas on integration in the nervous system , 1992, Trends in Neurosciences.

[27]  J. Holden,et al.  Visual evoked potentials and positron emission tomographic mapping of regional cerebral blood flow and cerebral metabolism: can the neuronal potential generators be visualized? , 1982, Electroencephalography and clinical neurophysiology.

[28]  T. Ogden,et al.  The oscillatory waves of the primate electroretinogram. , 1973, Vision research.

[29]  M. Marmor,et al.  Standard for Clinical Electroretinography: International Standardization Committee , 1989 .

[30]  H. Spekreijse,et al.  Principal components analysis for source localization of VEPs in man , 1987, Vision Research.

[31]  C. Baker,et al.  Current source density analysis of linear and non‐linear components of the primate electroretinogram. , 1988, The Journal of physiology.

[32]  B. Connors,et al.  Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons. , 1991, Science.

[33]  M. Steriade.  The flash-evoked afterdischarge. , 1968, Brain research.

[34]  J. Kulikowski,et al.  Electrophysiological and Psychophysical Responses to Modulation of Contrast of a Grating Pattern , 1972, Perception.

[35]  G Rosadini,et al.  Human flash-VEP and quantitative EEG are independently affected by acute scopolamine. , 1993, Electroencephalography and clinical neurophysiology.

[36]  D M Parker,et al.  The Spatial Selectivity of Early and Late Waves within the Human Visual Evoked Response , 1977, Perception.

[37]  G. Plant,et al.  Transient visually evoked potentials to the pattern reversal and onset of sinusoidal gratings. , 1983, Electroencephalography and clinical neurophysiology.

[38]  D. Regan,et al.  Human brain electrophysiology , 1989 .

[39]  R. Cracco,et al.  Visual evoked potential in man: early oscillatory potentials. , 1978, Electroencephalography and clinical neurophysiology.

[40]  M. Ghilardi,et al.  The importance of stimulus selection in VEP practice: the clinical relevance of visual physiology , 1986 .

[41]  W. Skrandies.  Scalp potential fields evoked by grating stimuli: effects of spatial frequency and orientation. , 1984, Electroencephalography and clinical neurophysiology.

[42]  J. Dowling,et al.  The oscillatory potentials of the mudpuppy retina. , 1978, Investigative ophthalmology & visual science.

[43]  A. Ducati,et al.  Neuronal generators of the visual evoked potentials: intracerebral recording in awake humans. , 1988, Electroencephalography and clinical neurophysiology.

[44]  H. P. Meles,et al.  Average multichannel EEG potential fields evoked from upper and lower hemi-retina: latency differences. , 1977, Electroencephalography and clinical neurophysiology.

[45]  D. Tolhurst,et al.  Psychophysical evidence for sustained and transient detectors in human vision , 1973, The Journal of physiology.

[46]  R W DOTY,et al.  Oscillatory potentials in the visual system of cats and monkeys , 1963, The Journal of physiology.

[47]  W. Cobb,et al.  The latency and form in man of the occipital potentials evoked by bright flashes , 1960, The Journal of physiology.

[48]  J. Brannan,et al.  A short latency cortical component of the foveal VEP is revealed by hemifield stimulation. , 1992, Electroencephalography and clinical neurophysiology.

[49]  I. Rosén,et al.  DIAGNOSTIC VALUE OF VISUAL EVOKED RESPONSE, CLINICAL EYE EXAMINATION AND CSF ANALYSIS IN CHRONIC MYELOPATHY , 1977, Acta neurologica Scandinavica.

[50]  R. Llinás,et al.  Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices. , 1980, The Journal of physiology.

[51]  J. Bouyer,et al.  Fast fronto-parietal rhythms during combined focused attentive behaviour and immobility in cat: cortical and thalamic localizations. , 1981, Electroencephalography and clinical neurophysiology.

[52]  J. Kulikowski,et al.  The effect of nitrous oxide on the relation between the evoked potential and contrast threshold. , 1973, Vision research.

[53]  A. Cowey,et al.  The ganglion cell and cone distributions in the monkey's retina: Implications for central magnification factors , 1985, Vision Research.

[54]  Michael Bach,et al.  Principles and practice of clinical electrophysiology of vision , 1991 .

[55]  M. Wright,et al.  Evidence for "sustained" and "transient" neurones in the cat's visual cortex. , 1974, Vision research.

[56]  F. Campbell,et al.  Electrophysiological evidence for the existence of orientation and size detectors in the human visual system , 1970, The Journal of physiology.

[57]  Matthias Korth.  Human fast retinal potentials and the spatial properties of a visual stimulus , 1981, Vision Research.

[58]  R. Llinás,et al.  Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage‐dependent ionic conductances. , 1981, The Journal of physiology.

[59]  F. Ratliff,et al.  Bicuculline enhances a negative component and diminishes a positive component of the visual evoked cortical potential in the cat. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[60]  Hiroko M. Sakai,et al.  Chapter 6 Neuron network in catfish retina: 1968–1987 , 1988 .

[61]  M. Ariel,et al.  Rhythmicity in rabbit retinal ganglion cell responses , 1983, Vision Research.