Nanomedicine: Techniques, Potentials, and Ethical Implications

Nanotechnology is concerned with materials and systems whose structures and components exhibit novel physical, chemical, and biological properties due to their nanoscale size. This paper focuses on what is known as nanomedicine, referring to the application of nanotechnology to medicine. We consider the use and potentials of emerging nanoscience techniques in medicine such as nanosurgery, tissue engineering, and targeted drug delivery, and we discuss the ethical questions that these techniques raise. The ethical considerations involved in nanomedicine are related to risk assessment in general, somatic-cell versus germline-cell therapy, the enhancement of human capabilities, research into human embryonic stem cells and the toxicity, uncontrolled function and self-assembly of nanoparticles. The ethical considerations associated with the application of nanotechnology to medicine have not been greatly discussed. This paper aims to balance clear ethical discussion and sound science and so provide nanotechnologists and biotechnologists with tools to assess ethical problems in nanomedicine.

[1]  David B. Warheit,et al.  NANOPARTICLES: HEALTH IMPACTS? , 2004 .

[2]  D. Degrazia,et al.  Moving forward in bioethical theory: theories, cases, and specified principlism. , 1992, The Journal of medicine and philosophy.

[3]  M. Evans.  Ethical sourcing of human embryonic stem cells — rational solutions? , 2005, Nature Reviews Molecular Cell Biology.

[4]  R. Freitas.  Nanotechnology, nanomedicine and nanosurgery. , 2005, International journal of surgery.

[5]  Kevin R. Smith.  Gene therapy: theoretical and bioethical concepts. , 2003, Archives of medical research.

[6]  Chikashi Nakamura,et al.  Mechanical sensing of the penetration of various nanoneedles into a living cell using atomic force microscopy. , 2005, Biosensors & bioelectronics.

[7]  H. Richardson,et al.  Specifying, balancing, and interpreting bioethical principles. , 2000, The Journal of medicine and philosophy.

[8]  B. Lustig.  The method of 'principlism': a critique of the critique. , 1992, The Journal of medicine and philosophy.

[9]  R. M. Satava,et al.  Disruptive visions: Biosurgery , 2003, Surgical Endoscopy And Other Interventional Techniques.

[10]  H. Engelhardt,et al.  Critical care: why there is no global bioethics , 2005, Current opinion in critical care.

[11]  Jean-Claude Latombe,et al.  Image-Guided Robotic Radiosurgery , 1994, Modelling and Planning for Sensor Based Intelligent Robot Systems.

[12]  D. Riva,et al.  Robotics in child neurosurgery , 2000, Child's Nervous System.

[13]  T. Xia,et al.  Toxic Potential of Materials at the Nanolevel , 2006, Science.

[14]  L. Zoloth.  Seeing the duties to all. , 2001, The Hastings Center report.

[15]  R. Lindsay.  Enhancements and Justice: Problems in Determining the Requirements of Justice in a Genetically Transformed Society , 2005, Kennedy Institute of Ethics journal.

[16]  LeRoy Walters.  Human Embryonic Stem Cell Research: An Intercultural Perspective , 2004, Kennedy Institute of Ethics journal.

[17]  L. Walters.  The ethics of human gene therapy , 1986, Nature.

[18]  Chikashi Nakamura,et al.  Nanoscale operation of a living cell using an atomic force microscope with a nanoneedle. , 2005, Nano letters.

[19]  K. Leong,et al.  The design of scaffolds for use in tissue engineering. Part II. Rapid prototyping techniques. , 2002, Tissue engineering.

[20]  B. A. Sonal Lalan,et al.  Tissue Engineering and Its Potential Impact on Surgery , 2001, World Journal of Surgery.

[21]  I. Mwase.  Genetic Enhancement and the Fate of the Worse Off , 2005, Kennedy Institute of Ethics journal.

[22]  D. Neri,et al.  Perils and deficiencies of the European Convention on Human Rights and Biomedicine. , 2010, The Journal of medicine and philosophy.

[23]  T. Beauchamp.  A Defense of the Common Morality , 2003, Kennedy Institute of Ethics journal.

[24]  Lustig Ba.  The method of 'principlism': a critique of the critique. , 1992 .

[25]  R. Green.  Last Word: Imagining the Future , 2005, Kennedy Institute of Ethics journal.

[26]  Daniel Ratner,et al.  Nanotechnology: A Gentle Introduction to the Next Big Idea , 2002 .

[27]  R. Satava.  Disruptive visions: Moral and ethical challenges from advanced technology and issues for the new generation of surgeons , 2002 .

[28]  M. Ebbesen.  The Golden Rule and Bioethics. A Reflection upon the Foundation of Ethics , 2002 .

[29]  C. Haberzettl,et al.  INSTITUTE OF PHYSICS PUBLISHING NANOTECHNOLOGY Nanotechnology 13 (2002) R9–R13 PII: S0957-4484(02)38410-1 Tutorial Nanomedicine: destination or journey? , 2022 .

[30]  Patricia J. Zettler,et al.  A New Era in the Ethics of Human Embryonic Stem Cell Research , 2005, Stem cells.

[31]  Mehmet Fatih Yanik,et al.  Neurosurgery: Functional regeneration after laser axotomy , 2004, Nature.

[32]  M. Roco.  Broader Societal Issues of Nanotechnology , 2003 .

[33]  H. Engelhardt.  Critical care: why there is no global bioethics. , 2005, Current opinion in critical care.

[34]  T. Beauchamp,et al.  Principlism and Its Alleged Competitors , 1995, Kennedy Institute of Ethics journal.

[35]  Sangeeta N Bhatia,et al.  Engineering liver therapies for the future. , 2002, Tissue engineering.

[36]  C. Strong.  Specified principlism: what is it, and does it really resolve cases better than casuistry? , 2000, The Journal of medicine and philosophy.

[37]  A. C. Hunter,et al.  Nanomedicine: current status and future prospects , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[38]  Karsten König,et al.  Laser tweezers and multiphoton microscopes in life sciences , 2000, Histochemistry and Cell Biology.

[39]  N. Bostrom.  In defense of posthuman dignity. , 2005, Bioethics.

[40]  A. Hedgecoe,et al.  Critical bioethics: beyond the social science critique of applied ethics. , 2004, Bioethics.

[41]  N. Wivel,et al.  Germ-line gene modification and disease prevention: some medical and ethical perspectives. , 1993, Science.

[42]  Jason Hipp,et al.  Tissue engineering, stem cells, cloning, and parthenogenesis: new paradigms for therapy , 2004, Journal of experimental & clinical assisted reproduction.

[43]  W. Heckl,et al.  Nanotechnology and medicine , 2004, 4th IEEE Conference on Nanotechnology, 2004..

[44]  O. O’neill.  Practical principles & practical judgment. , 2001, The Hastings Center report.

[45]  Mehmet Toner,et al.  Hepatic tissue engineering for adjunct and temporary liver support: critical technologies. , 2004, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[46]  P. J. Langer,et al.  Human germline gene therapy reconsidered. , 2001, Human gene therapy.

[47]  Karsten König,et al.  Femtosecond near-infrared laser pulses as a versatile non-invasive tool for intra-tissue nanoprocessing in plants without compromising viability. , 2002, The Plant journal : for cell and molecular biology.

[48]  B. Pedersen,et al.  Using empirical research to formulate normative ethical principles in biomedicine , 2007, Medicine, health care, and philosophy.

[49]  S. Holm,et al.  Not just autonomy--the principles of American biomedical ethics. , 1995, Journal of medical ethics.

[50]  K. Eric Drexler,et al.  Engines of Creation: the Coming Era of Nanotechnology , 1986 .

[51]  M. Kaiser,et al.  Assessing ethics and animal welfare in animal biotechnology for farm production. , 2005, Revue scientifique et technique.

[52]  Fritz Allhoff.  Germ-Line Genetic Enhancement and Rawlsian Primary Goods , 2005, Kennedy Institute of Ethics journal.

[53]  T. Beauchamp.  Reply to Strong on principlism and casuistry. , 2000, The Journal of medicine and philosophy.