Improved naming after TMS treatments in a chronic, global aphasia patient – case report

We report improved ability to name pictures at 2 and 8 months after repetitive transcranial magnetic stimulation (rTMS) treatments to the pars triangularis portion of right Broca’s homologue in a 57 year-old woman with severe nonfluent/global aphasia (6.5 years post left basal ganglia bleed, subcortical lesion). TMS was applied at 1 Hz, 20 minutes a day, 10 days, over a two-week period. She received no speech therapy during the study. One year after her TMS treatments, she entered speech therapy with continued improvement. TMS may have modulated activity in the remaining left and right hemisphere neural network for naming.

[1]  박성종,et al.  A Study on Primarily Development of the Korean Version of BASA(Boston Assessment of Severe Aphasia) , 2006 .

[2]  Á. Pascual-Leone,et al.  Improved picture naming in chronic aphasia after TMS to part of right Broca’s area: An open-protocol study , 2005, Brain and Language.

[3]  Markus Zahn,et al.  Three-dimensional head model Simulation of transcranial magnetic stimulation , 2004, IEEE Transactions on Biomedical Engineering.

[4]  Argye E. Hillis,et al.  Variability in subcortical aphasia is due to variable sites of cortical hypoperfusion , 2004, Brain and Language.

[5]  R. Adolphs,et al.  Neural systems behind word and concept retrieval , 2004, Cognition.

[6]  Harold Goodglass,et al.  Overt propositional speech in chronic nonfluent aphasia studied with the dynamic susceptibility contrast fMRI method , 2004, NeuroImage.

[7]  Karsten Specht,et al.  Recovery of semantic word processing in global aphasia: a functional MRI study. , 2004, Brain research. Cognitive brain research.

[8]  D. Perani,et al.  A fMRI study of word retrieval in aphasia , 2003, Brain and Language.

[9]  R. Salmelin,et al.  Adult Brain Plasticity Elicited by Anomia Treatment , 2003, Journal of Cognitive Neuroscience.

[10]  E. Bisiach,et al.  1 Hz repetitive transcranial magnetic stimulation of the unaffected hemisphere ameliorates contralesional visuospatial neglect in humans , 2003, Neuroscience Letters.

[11]  P. Matthews,et al.  Semantic Processing in the Left Inferior Prefrontal Cortex: A Combined Functional Magnetic Resonance Imaging and Transcranial Magnetic Stimulation Study , 2003, Journal of Cognitive Neuroscience.

[12]  Abraham Z. Snyder,et al.  Word Retrieval Learning Modulates Right Frontal Cortex in Patients with Left Frontal Damage , 2002, Neuron.

[13]  A. Léger,et al.  Neural Substrates of Spoken Language Rehabilitation in an Aphasic Patient: An fMRI Study , 2002, NeuroImage.

[14]  R. Buckner,et al.  Common Prefrontal Regions Coactivate with Dissociable Posterior Regions during Controlled Semantic and Phonological Tasks , 2002, Neuron.

[15]  Myoung-Hwan Ko,et al.  Reorganization of cortical language areas in patients with aphasia: a functional MRI study. , 2002, Yonsei medical journal.

[16]  A. Lecours,et al.  The contribution of the right cerebral hemisphere to the recovery from aphasia: a single longitudinal case study , 2002, Brain and Language.

[17]  Á. Pascual-Leone,et al.  Subthreshold low frequency repetitive transcranial magnetic stimulation selectively decreases facilitation in the motor cortex , 2002, Clinical Neurophysiology.

[18]  Á. Pascual-Leone,et al.  Enhanced visual spatial attention ipsilateral to rTMS-induced 'virtual lesions' of human parietal cortex , 2001, Nature Neuroscience.

[19]  Karl J. Friston,et al.  Dynamic Diaschisis: Anatomically Remote and Context-Sensitive Human Brain Lesions , 2001, Journal of Cognitive Neuroscience.

[20]  A. Kertesz,et al.  Right Hemisphere Semantic Processing of Visual Words in an Aphasic Patient: An fMRI Study , 2000, Brain and Language.

[21]  Á. Pascual-Leone,et al.  Modulation of corticospinal excitability by repetitive transcranial magnetic stimulation , 2000, Clinical Neurophysiology.

[22]  S. Petersen,et al.  Comparison of Brain Activation during Word Retrieval Done Silently and Aloud Using fMRI , 2000, Brain and Cognition.

[23]  Mark S. George,et al.  Transcranial magnetic stimulation in neuropsychiatry , 2000 .

[24]  R. Töpper,et al.  Facilitation of picture naming after repetitive transcranial magnetic stimulation , 1999, Neurology.

[25]  K P George,et al.  Cortical language activation in stroke patients recovering from aphasia with functional MRI. , 1999, Stroke.

[26]  Yusaku Nakamura,et al.  Functional magnetic resonance imaging to word generation task in a patient with Broca’s aphasia , 1999, Journal of Neurology.

[27]  A. Schleicher,et al.  Broca's region revisited: Cytoarchitecture and intersubject variability , 1999, The Journal of comparative neurology.

[28]  S. Kiebel,et al.  Training-induced brain plasticity in aphasia. , 1999, Brain : a journal of neurology.

[29]  P M Rossini,et al.  Left frontal transcranial magnetic stimulation reduces contralesional extinction in patients with unilateral right brain damage. , 1999, Brain : a journal of neurology.

[30]  Alan C. Evans,et al.  The Neural Substrate of Picture Naming , 1999, Journal of Cognitive Neuroscience.

[31]  K. Meador,et al.  Localization and characterization of speech arrest during transcranial magnetic stimulation , 1999, Clinical Neurophysiology.

[32]  H. Karbe,et al.  Differential capacity of left and right hemispheric areas for compensation of poststroke aphasia , 1999, Annals of neurology.

[33]  M. Just,et al.  Plasticity of language-related brain function during recovery from stroke. , 1999, Stroke.

[34]  Á. Pascual-Leone,et al.  Low-frequency repetitive transcranial magnetic stimulation of the motor cortex in writer’s cramp , 1999, Neurology.

[35]  C. Price,et al.  Mechanisms of recovery from aphasia: evidence from positron emission tomography studies , 1999, Journal of neurology, neurosurgery, and psychiatry.

[36]  Irene P. Kan,et al.  Verb generation in patients with focal frontal lesions: a neuropsychological test of neuroimaging findings. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[37]  T. Weissman,et al.  Lesion site patterns in severe, nonverbal aphasia to predict outcome with a computer-assisted treatment program. , 1998, Archives of neurology.

[38]  M. Mimura,et al.  Prospective and retrospective studies of recovery in aphasia. Changes in cerebral blood flow and language functions. , 1998, Brain : a journal of neurology.

[39]  F. M. Mottaghy,et al.  Facilitation of picture naming by focal transcranial magnetic stimulation of Wernicke’s area , 1998, Experimental Brain Research.

[40]  Á. Pascual-Leone,et al.  Study and modulation of human cortical excitability with transcranial magnetic stimulation. , 1998, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[41]  P. Pietrini,et al.  Neurofunctional correlates of language reorganization after massive hemisphere stroke. , 1998, NeuroImage.

[42]  Douglas C. Noll,et al.  Different Neural Circuits Subserve Reading before and after Therapy for Acquired Dyslexia , 1998, Brain and Language.

[43]  J. Desmond,et al.  The role of left prefrontal cortex in language and memory. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[44]  F. Ovsiew,et al.  Paradoxical functional facilitation in brain-behavior research: a critical review. , 1997, Brain : a journal of neurology.

[45]  J. Rothwell,et al.  Techniques and mechanisms of action of transcranial stimulation of the human motor cortex , 1997, Journal of Neuroscience Methods.

[46]  Michael Weinrich,et al.  Remediating Production of Tense Morphology Improves Verb Retrieval in Chronic Aphasia , 1997, Brain and Language.

[47]  M. Hallett,et al.  Depression of motor cortex excitability by low‐frequency transcranial magnetic stimulation , 1997, Neurology.

[48]  H. Karbe,et al.  Speech-induced cerebral metabolic activation reflects recovery from aphasia , 1997, Journal of the Neurological Sciences.

[49]  D. Perani,et al.  A PET Follow-up Study of Recovery after Stroke in Acute Aphasics , 1997, Brain and Language.

[50]  Y. Samson,et al.  Recovery from nonfluent aphasia after melodic intonation therapy , 1996, Neurology.

[51]  K. Meador,et al.  Optimum stimulus parameters for lateralized suppression of speech with magnetic brain stimulation , 1996, Neurology.

[52]  N. Kapur Paradoxical functional facilitation in brain-behaviour research. A critical review. , 1996, Brain : a journal of neurology.

[53]  A. Damasio,et al.  A neural basis for lexical retrieval , 1996, Nature.

[54]  P. Vuilleumier,et al.  Unilateral spatial neglect recovery after sequential strokes , 1996, Neurology.

[55]  The Second International Conference on Functional Mapping of the Human Brain , 1995 .

[56]  Michael Weinrich,et al.  Training on an iconic communication system for severe aphasia can improve natural language production , 1995 .

[57]  R. Woods,et al.  Recovery from wernicke's aphasia: A positron emission tomographic study , 1995, Annals of neurology.

[58]  M. Naeser,et al.  Neuroimaging and Language Recovery in Stroke , 1994, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[59]  L. Friberg,et al.  Speech localization using repetitive transcranial magnetic stimulation , 1994, Neurology.

[60]  L. Turkstra,et al.  Melodic Intonation Therapy , 2018 .

[61]  Á. Pascual-Leone,et al.  Induction of speech arrest and counting errors with rapid‐rate transcranial magnetic stimulation , 1991, Neurology.

[62]  M Hallett,et al.  A theoretical calculation of the electric field induced in the cortex during magnetic stimulation. , 1991, Electroencephalography and clinical neurophysiology.

[63]  Robert T. Wertz,et al.  Computer-based visual communication in aphasia , 1989, Neuropsychologia.

[64]  M. Albert,et al.  Severe nonfluency in aphasia. Role of the medial subcallosal fasciculus and other white matter pathways in recovery of spontaneous speech. , 1989, Brain : a journal of neurology.

[65]  Robert T. Wertz,et al.  Aphasia: A Clinical Approach , 1989 .

[66]  G. Demeurisse,et al.  Language recovery in aphasic stroke patients: Clinical, CT and CBF studies , 1987 .

[67]  E. Metter Neuroanatomy and physiology of aphasia: Evidence from positron emission tomography , 1987 .

[68]  E. Kaplan,et al.  The Boston naming test , 2001 .

[69]  M. Sarno,et al.  Some observations on the nature of recovery in global aphasia after stroke , 1981, Brain and Language.

[70]  J. G. Snodgrass,et al.  A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. , 1980, Journal of experimental psychology. Human learning and memory.

[71]  N. Helm,et al.  Voluntary Control of Involuntary Utterances: A Treatment Approach for Severe Aphasia , 1980 .

[72]  A. Kertesz,et al.  Recovery patterns and prognosis in aphasia. , 1977, Brain : a journal of neurology.

[73]  Howard Gardner,et al.  Visual communication in aphasia , 1976, Neuropsychologia.

[74]  A. Holland,et al.  Method: melodic intonation therapy for aphasia. , 1976, The Journal of speech and hearing disorders.

[75]  H. Gardner,et al.  Can linguistic competence be dissociated from natural language functions? , 1975, Nature.

[76]  M. Albert,et al.  Aphasia rehabilitation resulting from melodic intonation therapy. , 1974, Cortex; a journal devoted to the study of the nervous system and behavior.

[77]  I. T. Draper THE ASSESSMENT OF APHASIA AND RELATED DISORDERS , 1973 .

[78]  M. Albert,et al.  Melodic intonation therapy for aphasia. , 1973, Archives of neurology.

[79]  E. Kaplan,et al.  The assessment of aphasia and related disorders , 1972 .

[80]  J. Czopf [Role of the non-dominant hemisphere in the restitution of speech in aphasia]. , 1972, Archiv fur Psychiatrie und Nervenkrankheiten.

[81]  M. Kinsbourne The Minor Cerebral Hemisphere , 1971 .

[82]  M. Kinsbourne The minor cerebral hemisphere as a source of aphasic speech. , 1971, Archives of neurology.

[83]  H. Kucera,et al.  Computational analysis of present-day American English , 1967 .