Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy.

[1]  S. Dische,et al.  Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers. , 1992, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[2]  M. Horsman.  Carbogen and nicotinamide: expectations too high? (response to J. Martin Brown) , 1992, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[3]  J. Collier,et al.  A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments. , 1991, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[4]  M. Horsman,et al.  Nicotinamide, Fluosol DA and Carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo. , 1991, British Journal of Cancer.

[5]  J. Overgaard,et al.  Combination of nicotinamide and hyperthermia to eliminate radioresistant chronically and acutely hypoxic tumor cells. , 1990, Cancer research.

[6]  M. Trotter,et al.  Effect of nicotinamide on the microregional heterogeneity of oxygen delivery within a murine tumor. , 1990, Journal of the National Cancer Institute.

[7]  D. Hirst,et al.  Calcium antagonists as radiation modifiers: site specificity in relation to tumor response. , 1989, International journal of radiation oncology, biology, physics.

[8]  J. Overgaard,et al.  Radiosensitization by nicotinamide in tumors and normal tissues: the importance of tissue oxygenation status. , 1989, International journal of radiation oncology, biology, physics.

[9]  D. Hirst,et al.  Chlorophenoxy acetic acid derivatives as hemoglobin modifiers and tumor radiosensitizers. , 1989, International journal of radiation oncology, biology, physics.

[10]  J. Brown,et al.  Tumor radiosensitization by nicotinamide: a result of improved perfusion and oxygenation. , 1989, Radiation research.

[11]  J. Brown,et al.  Mechanism of action of the selective tumor radiosensitizer nicotinamide. , 1988, International journal of radiation oncology, biology, physics.

[12]  M. Horsman,et al.  Radiosensitization by nicotinamide in vivo: a greater enhancement of tumor damage compared to that of normal tissues. , 1987, Radiation research.

[13]  D. Chaplin,et al.  Acute hypoxia in tumors: implications for modifiers of radiation effects. , 1986, International journal of radiation oncology, biology, physics.

[14]  D. Siemann,et al.  Tumor radiosensitization through reductions in hemoglobin affinity. , 1986, International journal of radiation oncology, biology, physics.

[15]  A. Rademaker,et al.  Effects of megavitamin therapy on children with attention deficit disorders. , 1984, Pediatrics.

[16]  B. Teicher,et al.  Perfluorochemical emulsions can increase tumor radiosensitivity. , 1984, Science.

[17]  W. Kaelin,et al.  Effect of verapamil on malignant tissue blood flow in SMT-2A tumor-bearing rats. , 1982, Cancer research.

[18]  C. W. Hastings,et al.  Reactions to niacinamide. , 1981, Journal of the American Academy of Dermatology.

[19]  J. D. de Vries,et al.  Determination of nicotinamide in human plasma and urine by ion-pair reversed-phase high-performance liquid chromatography. , 1980, Journal of chromatography.

[20]  J. Overgaard.  Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding normal tissue in vivo. , 1980, International journal of radiation oncology, biology, physics.

[21]  O. S. Nielsen,et al.  THE ROLE OF TISSUE ENVIRONMENTAL FACTORS ON THE KINETICS AND MORPHOLOGY OF TUMOR CELLS EXPOSED TO HYPERTHERMIA * , 1980, Annals of the New York Academy of Sciences.

[22]  L. Gerweck,et al.  Response of cells to hyperthermia under acute and chronic hypoxic conditions. , 1979, Cancer research.

[23]  H. Zackheim.  Topical 6-aminonicotinamide plus oral niacinamide therapy for psoriasis. , 1978, Archives of dermatology.

[24]  W. J. Turner,et al.  Metabolic response of humans to ingestion of nicotinic acid and nicotinamide. , 1976, Clinical chemistry.

[25]  J. Boyer,et al.  Hepatic toxicity from large doses of vitamin B3 (nicotinamide). , 1973, The New England journal of medicine.

[26]  David R. Woerner,et al.  Oxygen, oxygen plus carbon dioxide, and radiation therapy of a mouse mammary carcinoma , 1972, Cancer.

[27]  G. H. Greenbaum.  An evaluation of niacinamide in the treatment of childhood schizophrenia. , 1970, The American journal of psychiatry.

[28]  H. Lehmann,et al.  Nicotinic acid as adjuvant therapy in newly admitted schizophrenic patients. , 1970, Canadian Medical Association journal.

[29]  R. Gholson,et al.  Isolation and identification of two new nicotinamide metabolites. , 1969, The Journal of biological chemistry.

[30]  S. Chaykin,et al.  THE FATE OF NICOTINAMIDE IN THE MOUSE; TISSUE METABOLITES. , 1965, Biochimica et biophysica acta.

[31]  S. Chaykin,et al.  THE FATE OF NICOTINAMIDE IN THE MOUSE. URINARY METABOLITES. , 1965, The Journal of biological chemistry.

[32]  N. Kaplan,et al.  Metabolites of nicotinamide in mouse urine. Effects of azaserine. , 1961 .

[33]  A. Rojas.  ARCON: accelerated radiotherapy with carbogen and nicotinamide. , 1992, BJR supplement.

[34]  P. Kristjansen,et al.  Biochemical and physiological changes induced by nicotinamide in a C3H mouse mammary carcinoma and CDF1 mice. , 1992, International journal of radiation oncology, biology, physics.

[35]  S. Bentzen,et al.  Direct estimation of the fraction of hypoxic cells from tumour--control data obtained under aerobic and clamped conditions. , 1991, International journal of radiation biology.

[36]  A. Rojas.  Radiosensitization with normobaric oxygen and carbogen. , 1991, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[37]  S. Rockwell.  Use of a perfluorochemical emulsion to improve oxygenation in a solid tumor. , 1985, International journal of radiation oncology, biology, physics.

[38]  D. Hawkins.  Treatment of schizophrenia based on the medical model. , 1968 .