Conference on ‘Nutrient-nutrient interaction’ Symposium 2: Nutrient interactions and their role in protection from chronic diseases β-Carotene in the human body: metabolic bioactivation pathways – from digestion to tissue distribution and excretion

Torsten Bohn, Charles Desmarchelier, Sedef N. El, Jaap Keijer, Evert van Schothorst, Ralph Rühl* and Patrick Borel Luxembourg Institute of Health, rue 1 A-B Thomas Edison, L-1445 Strassen, Luxembourg C2VN, Aix-Marseille Univ., INRA, INSERM, Marseille, France Engineering Faculty, Food Engineering Department, Ege University, Izmir, Turkey Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands Paprika Bioanalytics BT, Debrecen, Hungary

[1]  A. D. de Lera,et al.  9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of retinoid X receptor and the active ligand of a potential new vitamin A category: vitamin A5 , 2018, Nutrition reviews.

[2]  P. Borel,et al.  Production of asymmetric oxidative metabolites of [13C]-β-carotene during digestion in the gastrointestinal lumen of healthy men. , 2018, The American journal of clinical nutrition.

[3]  D. L. Graham,et al.  Reduced Carotenoid and Retinoid Concentrations and Altered Lycopene Isomer Ratio in Plasma of Atopic Dermatitis Patients , 2018, Nutrients.

[4]  A. Palou,et al.  Retinoic Acid Increases Fatty Acid Oxidation and Irisin Expression in Skeletal Muscle Cells and Impacts Irisin In Vivo , 2018, Cellular Physiology and Biochemistry.

[5]  L. Hoffmann,et al.  Magnesium affects spinach carotenoid bioaccessibility in vitro depending on intestinal bile and pancreatic enzyme concentrations. , 2018, Food chemistry.

[6]  C. Soukoulis,et al.  A comprehensive overview on the micro- and nano-technological encapsulation advances for enhancing the chemical stability and bioavailability of carotenoids , 2018, Critical reviews in food science and nutrition.

[7]  P. Bernstein,et al.  RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye , 2017, Proceedings of the National Academy of Sciences.

[8]  T. Grauwet,et al.  Lipid digestion, micelle formation and carotenoid bioaccessibility kinetics: Influence of emulsion droplet size. , 2017, Food chemistry.

[9]  J. L. Napoli Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases. , 2017, Pharmacology & therapeutics.

[10]  P. Borel,et al.  Are lutein, lycopene, and β-carotene lost through the digestive process? , 2017, Food & function.

[11]  P. Borel,et al.  Overview of carotenoid bioavailability determinants: From dietary factors to host genetic variations , 2017 .

[12]  P. Borel,et al.  Genetic Variations Associated with Vitamin A Status and Vitamin A Bioavailability , 2017, Nutrients.

[13]  M. Hoekstra SR-BI as target in atherosclerosis and cardiovascular disease - A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease. , 2017, Atherosclerosis.

[14]  A. Ross,et al.  Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models. , 2017, Advances in nutrition.

[15]  T. Bohn Bioactivity of Carotenoids - Chasms of Knowledge. , 2017, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[16]  A. Alegría,et al.  Effect of processing on the bioaccessibility of bioactive compounds – A review focusing on carotenoids, minerals, ascorbic acid, tocopherols and polyphenols , 2017 .

[17]  L. Dragsted,et al.  Host‐related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans , 2017, Molecular nutrition & food research.

[18]  Y. Shidoji,et al.  Common SNP rs6564851 in the BCO1 Gene Affects the Circulating Levels of β-Carotene and the Daily Intake of Carotenoids in Healthy Japanese Women , 2016, PloS one.

[19]  C. Buffière,et al.  Dietary calcium impairs tomato lycopene bioavailability in healthy humans , 2016, British Journal of Nutrition.

[20]  M. Golczak,et al.  Molecular Basis for Vitamin A Uptake and Storage in Vertebrates , 2016, Nutrients.

[21]  S. Walrand,et al.  Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue , 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[22]  Hann Qian Lim,et al.  Retinoic acid is abundantly detected in different depots of adipose tissue by SERS , 2016, Adipocyte.

[23]  E. Harrison,et al.  Mechanisms of selective delivery of xanthophylls to retinal pigment epithelial cells by human lipoproteins , 2016, Journal of Lipid Research.

[24]  L. Wood,et al.  Consuming High-Carotenoid Fruit and Vegetables Influences Skin Yellowness and Plasma Carotenoids in Young Women: A Single-Blind Randomized Crossover Trial. , 2016, Journal of the Academy of Nutrition and Dietetics.

[25]  M. Motilva,et al.  Stability and metabolism of Arbutus unedo bioactive compounds (phenolics and antioxidants) under in vitro digestion and colonic fermentation. , 2016, Food chemistry.

[26]  A. D. de Lera,et al.  An Endogenous Mammalian Retinoid X Receptor Ligand, At Last! , 2016, ChemMedChem.

[27]  L. Hoffmann,et al.  Carotenoid and polyphenol bioaccessibility and cellular uptake from plum and cabbage varieties. , 2016, Food chemistry.

[28]  M. Olivo,et al.  Retinoic Acid Mediates Visceral-Specific Adipogenic Defects of Human Adipose-Derived Stem Cells , 2016, Diabetes.

[29]  S. Henning,et al.  Biomarkers of Dietary Intake Are Correlated with Corresponding Measures from Repeated Dietary Recalls and Food-Frequency Questionnaires in the Adventist Health Study-2. , 2016, The Journal of nutrition.

[30]  A. D. de Lera,et al.  TSLP expression in the skin is mediated via RARγ-RXR pathways. , 2016, Immunobiology.

[31]  S. Ghosh,et al.  Eicosapentaenoic acid inhibits intestinal β-carotene absorption by downregulation of lipid transporter expression via PPAR-α dependent mechanism. , 2016, Archives of biochemistry and biophysics.

[32]  Y. Ikoma,et al.  High-serum carotenoids associated with lower risk for developing type 2 diabetes among Japanese subjects: Mikkabi cohort study , 2015, BMJ Open Diabetes Research and Care.

[33]  S. W. Park,et al.  Carotenoids from fruits and vegetables: Chemistry, analysis, occurrence, bioavailability and biological activities. , 2015, Food research international.

[34]  P. Borel,et al.  A Combination of Single-Nucleotide Polymorphisms Is Associated with Interindividual Variability in Dietary β-Carotene Bioavailability in Healthy Men. , 2015, The Journal of nutrition.

[35]  P. Aaby,et al.  Neonatal vitamin A supplementation associated with increased atopy in girls , 2015, Allergy.

[36]  S. Bandinelli,et al.  Relationship between Carotenoids, Retinol, and Estradiol Levels in Older Women , 2015, Nutrients.

[37]  J. Gregory,et al.  High provitamin A carotenoid serum concentrations, elevated retinyl esters, and saturated retinol-binding protein in Zambian preschool children are consistent with the presence of high liver vitamin A stores. , 2015, The American journal of clinical nutrition.

[38]  N. Rochel,et al.  9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice , 2015, PLoS genetics.

[39]  P. Borel,et al.  Lycopene bioavailability is associated with a combination of genetic variants. , 2015, Free radical biology & medicine.

[40]  O. Dangles,et al.  Stability of bacterial carotenoids in the presence of iron in a model of the gastric compartment - comparison with dietary reference carotenoids. , 2015, Archives of biochemistry and biophysics.

[41]  A. Palou,et al.  Carotenoids and their conversion products in the control of adipocyte function, adiposity and obesity. , 2015, Archives of biochemistry and biophysics.

[42]  L. Quadro,et al.  Tissue- and sex-specific effects of β-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice. , 2015, Archives of biochemistry and biophysics.

[43]  D. van der A,et al.  Dietary intake of carotenoids and risk of type 2 diabetes. , 2015, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[44]  I. Barshack,et al.  9-cis β-carotene Inhibits Atherosclerosis Development in Female LDLR-/- Mice , 2015 .

[45]  J. Storch,et al.  Enterocyte fatty acid-binding proteins (FABPs): different functions of liver and intestinal FABPs in the intestine. , 2015, Prostaglandins, leukotrienes, and essential fatty acids.

[46]  R. Rühl,et al.  Steroid concentrations in patients with atopic dermatitis: reduced plasma dehydroepiandrosterone sulfate and increased cortisone levels , 2015, The British journal of dermatology.

[47]  T. Bohn,et al.  Carotenoids, inflammation, and oxidative stress--implications of cellular signaling pathways and relation to chronic disease prevention. , 2014, Nutrition research.

[48]  P. Borel,et al.  Interindividual variability of lutein bioavailability in healthy men: characterization, genetic variants involved, and relation with fasting plasma lutein concentration. , 2014, The American journal of clinical nutrition.

[49]  O. Ziouzenkova,et al.  Enzymatic intracrine regulation of white adipose tissue , 2014, Hormone molecular biology and clinical investigation.

[50]  S. N. El,et al.  In Vitro Models for Studying Secondary Plant Metabolite Digestion and Bioaccessibility. , 2014, Comprehensive reviews in food science and food safety.

[51]  M. McCullough,et al.  Dietary carotenoids are associated with cardiovascular disease risk biomarkers mediated by serum carotenoid concentrations. , 2014, The Journal of nutrition.

[52]  J. Keijer,et al.  Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung. , 2014, Toxicology.

[53]  R. Rühl,et al.  Increased FADS2-Derived n-6 PUFAs and Reduced n-3 PUFAs in Plasma of Atopic Dermatitis Patients , 2014, Skin Pharmacology and Physiology.

[54]  R. Evans,et al.  Nuclear Receptors, RXR, and the Big Bang , 2014, Cell.

[55]  E. Harrison,et al.  The Human Enzyme That Converts Dietary Provitamin A Carotenoids to Vitamin A Is a Dioxygenase* , 2014, The Journal of Biological Chemistry.

[56]  E. Harrison,et al.  Substrate Specificity of Purified Recombinant Human β-Carotene 15,15′-Oxygenase (BCO1)* , 2013, The Journal of Biological Chemistry.

[57]  K. Palczewski,et al.  Two Carotenoid Oxygenases Contribute to Mammalian Provitamin A Metabolism* ♦ , 2013, The Journal of Biological Chemistry.

[58]  O. Dangles,et al.  Iron-induced oxidation of (all-E)-β-carotene under model gastric conditions: kinetics, products, and mechanism. , 2013, Free radical biology & medicine.

[59]  M. Ricote,et al.  Retinoid X receptors in macrophage biology , 2013, Trends in Endocrinology & Metabolism.

[60]  W. Blaner,et al.  Retinol and retinyl esters: biochemistry and physiology , 2013, Journal of Lipid Research.

[61]  E. Harrison,et al.  Carotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids , 2013, Journal of Lipid Research.

[62]  K. Ronkainen,et al.  Serum Carotenoids Reduce Progression of Early Atherosclerosis in the Carotid Artery Wall among Eastern Finnish Men , 2013, PloS one.

[63]  R. Álvarez,et al.  Regulation of Retinoid-Mediated Signaling Involved in Skin Homeostasis by RAR and RXR Agonists/Antagonists in Mouse Skin , 2013, PloS one.

[64]  P. Calder,et al.  CD36 and SR-BI are involved in cellular uptake of provitamin A carotenoids by Caco-2 and HEK cells, and some of their genetic variants are associated with plasma concentrations of these micronutrients in humans. , 2013, The Journal of nutrition.

[65]  R. Shivdasani,et al.  Genetics and Diet Regulate Vitamin A Production via the Homeobox Transcription Factor ISX* , 2013, The Journal of Biological Chemistry.

[66]  R. Rühl Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development , 2013, International Archives of Allergy and Immunology.

[67]  A. Wolk,et al.  Dietary, anthropometric, and lifestyle correlates of serum carotenoids in postmenopausal women , 2013, European Journal of Nutrition.

[68]  J. Cristol,et al.  Stability and bioaccessibility of different forms of carotenoids and vitamin A during in vitro digestion. , 2013, Food chemistry.

[69]  W. Willett,et al.  β-Carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms in relation to plasma carotenoid and retinol concentrations in women of European descent. , 2012, The American journal of clinical nutrition.

[70]  Pratik Aryal,et al.  Liver Retinol Transporter and Receptor for Serum Retinol-binding Protein (RBP4)* , 2012, The Journal of Biological Chemistry.

[71]  Steven Nusinowitz,et al.  Identification of DES1 as a Vitamin A Isomerase in Müller Glial Cells of the Retina , 2012, Nature chemical biology.

[72]  O. Dangles,et al.  Effects of physicochemical properties of carotenoids on their bioaccessibility, intestinal cell uptake, and blood and tissue concentrations. , 2012, Molecular nutrition & food research.

[73]  J. Erdman,et al.  An interaction between carotene‐15,15′‐monooxygenase expression and consumption of a tomato or lycopene‐containing diet impacts serum and testicular testosterone , 2012, International journal of cancer.

[74]  J. L. Napoli,et al.  Reorganization of cellular retinol-binding protein type 1 and lecithin:retinol acyltransferase during retinyl ester biosynthesis. , 2012, Biochimica et biophysica acta.

[75]  K. Palczewski,et al.  Lecithin:Retinol Acyltransferase Is Critical for Cellular Uptake of Vitamin A from Serum Retinol-binding Protein* , 2012, The Journal of Biological Chemistry.

[76]  U. Wahn,et al.  Serum Retinoic Acid and Atopy Among Children of Different Ethnic Origin Living in Germany , 2012, Journal of pediatric gastroenterology and nutrition.

[77]  A. Alkerwi,et al.  Contribution of violaxanthin, neoxanthin, phytoene and phytofluene to total carotenoid intake: Assessment in Luxembourg , 2012 .

[78]  U. Taschler,et al.  Retinyl ester hydrolases and their roles in vitamin A homeostasis , 2012, Biochimica et biophysica acta.

[79]  E. Reboul,et al.  Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes. , 2011, Progress in lipid research.

[80]  L. Hoffmann,et al.  Divalent minerals decrease micellarization and uptake of carotenoids and digestion products into Caco-2 cells. , 2011, The Journal of nutrition.

[81]  R. Godschalk,et al.  Gene expression response of mouse lung, liver and white adipose tissue to β-carotene supplementation, knockout of Bcmo1 and sex. , 2011, Molecular nutrition & food research.

[82]  J. Keijer,et al.  Beta-Carotene Reduces Body Adiposity of Mice via BCMO1 , 2011, PloS one.

[83]  K. Palczewski,et al.  A mitochondrial enzyme degrades carotenoids and protects against oxidative stress , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[84]  A. Ismail,et al.  Carotenoids and Their Isomers: Color Pigments in Fruits and Vegetables , 2011, Molecules.

[85]  W. Blaner,et al.  Vitamin A Metabolism: An Update , 2011, Nutrients.

[86]  Jesús Fernando Ayala-Zavala,et al.  The Role of Dietary Fiber in the Bioaccessibility and Bioavailability of Fruit and Vegetable Antioxidants , 2011, Journal of food science.

[87]  R. Crouch,et al.  Retinol dehydrogenases (RDHs) in the visual cycle. , 2010, Experimental eye research.

[88]  U. Wahn,et al.  Serum carotenoids and atopy among children of different ethnic origin living in Germany , 2010, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[89]  M. Lazar,et al.  Endogenous Ligands for Nuclear Receptors: Digging Deeper* , 2010, The Journal of Biological Chemistry.

[90]  G. Rimbach,et al.  Molecular and dietary regulation of beta,beta-carotene 15,15'-monooxygenase 1 (BCMO1). , 2010, Archives of biochemistry and biophysics.

[91]  R. Godschalk,et al.  Beta-carotene affects gene expression in lungs of male and female Bcmo1 −/− mice in opposite directions , 2010, Cellular and Molecular Life Sciences.

[92]  R. Godschalk,et al.  Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice. , 2010, Carcinogenesis.

[93]  M. Nieuwdorp,et al.  The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight. , 2010, Atherosclerosis.

[94]  R. Godschalk,et al.  Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene , 2010, Cellular and Molecular Life Sciences.

[95]  S. Kohlwein,et al.  Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver , 2009, Journal of Lipid Research.

[96]  S. Blanquet-Diot,et al.  Digestive stability of xanthophylls exceeds that of carotenes as studied in a dynamic in vitro gastrointestinal system. , 2009, The Journal of nutrition.

[97]  J. Hesketh,et al.  Two common single nucleotide polymorphisms in the gene encoding β‐carotene 15,15′‐monoxygenase alter β‐carotene metabolism in female volunteers , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[98]  Luigi Ferrucci,et al.  Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. , 2009, American journal of human genetics.

[99]  D. Possin,et al.  Localizations of visual cycle components in retinal pigment epithelium , 2009, Molecular vision.

[100]  H. Tajiri,et al.  Lecithin: retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver , 2009, Liver international : official journal of the International Association for the Study of the Liver.

[101]  B. Watzl,et al.  Modulation of plasma all-trans retinoic acid concentrations by the consumption of carotenoid-rich vegetables. , 2008, Nutrition.

[102]  T. Bohn Bioavailability of Non-Provitamin A Carotenoids , 2008 .

[103]  D. Lairon,et al.  Human fasting plasma concentrations of vitamin E and carotenoids, and their association with genetic variants in apo C-III, cholesteryl ester transfer protein, hepatic lipase, intestinal fatty acid binding protein and microsomal triacylglycerol transfer protein. , 2008, The British journal of nutrition.

[104]  W. Blaner,et al.  In vitro and in vivo characterization of retinoid synthesis from beta-carotene. , 2008, Archives of biochemistry and biophysics.

[105]  M. Failla,et al.  In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene. , 2008, The Journal of nutrition.

[106]  G. Siest,et al.  The Lipoprotein Lipase Serine 447 Stop Polymorphism Is Associated With Altered Serum Carotenoid Concentrations in the Stanislas Family Study , 2007, Journal of the American College of Nutrition.

[107]  D. Lairon,et al.  Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in genes involved in lipid metabolism. , 2007, The Journal of nutrition.

[108]  S. Andersson,et al.  Loss-of-function mutation in carotenoid 15,15'-monooxygenase identified in a patient with hypercarotenemia and hypovitaminosis A. , 2007, The Journal of nutrition.

[109]  M. Worm,et al.  Role of vitamin A elimination or supplementation diets during postnatal development on the allergic sensitisation in mice. , 2007, Molecular nutrition & food research.

[110]  R. Blomhoff,et al.  Quantitative high-throughput determination of endogenous retinoids in human plasma using triple-stage liquid chromatography/tandem mass spectrometry. , 2007, Rapid communications in mass spectrometry : RCM.

[111]  Christian Gluud,et al.  Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. , 2007, JAMA.

[112]  P. Ping,et al.  A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A , 2007, Science.

[113]  Manabu T. Nakamura,et al.  Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats. , 2006, The Journal of nutrition.

[114]  A. Palou,et al.  Remodeling of white adipose tissue after retinoic acid administration in mice. , 2006, Endocrinology.

[115]  E. Reboul,et al.  Bioaccessibility of carotenoids and vitamin E from their main dietary sources. , 2006, Journal of agricultural and food chemistry.

[116]  Ralph Rühl,et al.  Method to determine 4-oxo-retinoic acids, retinoic acids and retinol in serum and cell extracts by liquid chromatography/diode-array detection atmospheric pressure chemical ionisation tandem mass spectrometry. , 2006, Rapid communications in mass spectrometry : RCM.

[117]  Rune Blomhoff,et al.  Overview of retinoid metabolism and function. , 2006, Journal of neurobiology.

[118]  P. Chambon,et al.  Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes. , 2006, Genes & development.

[119]  T. Gundersen Methods for detecting and identifying retinoids in tissue. , 2006, Journal of neurobiology.

[120]  Albert K Groen,et al.  Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. , 2006, The Journal of clinical investigation.

[121]  M. Failla,et al.  Digestive Stability, micellarization, and uptake of beta-carotene isomers by Caco-2 human intestinal cells. , 2006, Journal of agricultural and food chemistry.

[122]  Elizabeth J Johnson,et al.  Carotenoid actions and their relation to health and disease. , 2005, Molecular aspects of medicine.

[123]  C. Chu,et al.  Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1. , 2005, Biochimica et biophysica acta.

[124]  E. Harrison,et al.  Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. , 2005, The Journal of nutrition.

[125]  J. Saurat,et al.  Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. , 2005, The Journal of investigative dermatology.

[126]  Reinhold Carle,et al.  Accumulation of all-trans-beta-carotene and its 9-cis and 13-cis stereoisomers during postharvest ripening of nine Thai mango cultivars. , 2005, Journal of agricultural and food chemistry.

[127]  F. Saura-calixto,et al.  Determination of beta-carotene and lutein available from green leafy vegetables by an in vitro digestion and colonic fermentation method. , 2005, Journal of agricultural and food chemistry.

[128]  H. Hauser,et al.  Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol. , 2005, Biochemistry.

[129]  A. Szántó,et al.  Retinoid X receptors: X-ploring their (patho)physiological functions , 2004, Cell Death and Differentiation.

[130]  Krzysztof Palczewski,et al.  Identification of All-trans-Retinol:All-trans-13,14-dihydroretinol Saturase* , 2004, Journal of Biological Chemistry.

[131]  M. Worm,et al.  Modulation of cytokine production by low and high retinoid diets in ovalbumin-sensitized mice. , 2004, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[132]  R. Carle,et al.  Effects of thermal processing on trans–cis-isomerization of β-carotene in carrot juices and carotene-containing preparations , 2003 .

[133]  C. Koebnick,et al.  Retinoid‐ and carotenoid‐enriched diets influence the ontogenesis of the immune system in mice , 2003, Immunology.

[134]  Bernhard Watzl,et al.  Supplementation of a Low-Carotenoid Diet with Tomato or Carrot Juice Modulates Immune Functions in Healthy Men , 2003, Annals of Nutrition and Metabolism.

[135]  R. Russell,et al.  Short-term (intestinal) and long-term (postintestinal) conversion of beta-carotene to retinol in adults as assessed by a stable-isotope reference method. , 2003, The American journal of clinical nutrition.

[136]  K. Yeum,et al.  Carotenoid-radical interactions. , 2003, Biochemical and biophysical research communications.

[137]  H. Nau,et al.  Chromatographic analysis of endogenous retinoids in tissues and serum. , 2003, Analytical biochemistry.

[138]  D. Lairon,et al.  Amounts and types of fatty acids in meals affect the pattern of retinoids secreted in human chylomicrons after a high-dose preformed vitamin A intake. , 2003, Metabolism: clinical and experimental.

[139]  R. Goldbohm,et al.  Human skin condition and its associations with nutrient concentrations in serum and diet. , 2003, The American journal of clinical nutrition.

[140]  K. Michaëlsson,et al.  Serum retinol levels and the risk of fracture. , 2003, The New England journal of medicine.

[141]  C. Bouteloup-Demange,et al.  Processing of vegetable-borne carotenoids in the human stomach and duodenum. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[142]  P. Borel Factors Affecting Intestinal Absorption of Highly Lipophilic Food Microconstituents (Fat-Soluble Vitamins, Carotenoids and Phytosterols) , 2003, Clinical chemistry and laboratory medicine.

[143]  S. Shoelson,et al.  Crystal Structure of the HNF4α Ligand Binding Domain in Complex with Endogenous Fatty Acid Ligand* , 2002, The Journal of Biological Chemistry.

[144]  P. Borel,et al.  Carotenoids, mostly the xanthophylls, exchange between plasma lipoproteins. , 2002, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[145]  H. Nau,et al.  Characterization of a new endogenous vitamin A metabolite. , 2002, Biochimica et biophysica acta.

[146]  D. Morel,et al.  Carotenoid uptake and secretion by CaCo-2 cells: beta-carotene isomer selectivity and carotenoid interactions. , 2002, Journal of lipid research.

[147]  D. Spiegelman,et al.  Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake. , 2002, The American journal of clinical nutrition.

[148]  S. Andersson,et al.  Biochemical Properties of Purified Recombinant Human β-Carotene 15,15′-Monooxygenase* , 2002, The Journal of Biological Chemistry.

[149]  P. Chambon,et al.  Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development , 2002, Nature Genetics.

[150]  P. Nilsson-ehle,et al.  Biological variation of retinoids in man , 2002, Scandinavian journal of clinical and laboratory investigation.

[151]  E. Harrison,et al.  Expression and characterization of a murine enzyme able to cleave beta-carotene. The formation of retinoids. , 2001, The Journal of biological chemistry.

[152]  W. Stahl,et al.  Effects of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells. , 2001, Archives of biochemistry and biophysics.

[153]  J. Erdman,et al.  Testosterone and food restriction modulate hepatic lycopene isomer concentrations in male F344 rats. , 2001, The Journal of nutrition.

[154]  X. D. Wang,et al.  Effects of physiological versus pharmacological beta-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets. , 2000, Carcinogenesis.

[155]  H. Nau,et al.  Biological effects and metabolism of 9-cis-retinoic acid and its metabolite 9,13-di-cis-retinoic acid in HaCaT keratinocytes in vitro: comparison with all-trans-retinoic acid , 2000, Archives of Dermatological Research.

[156]  J. Bertram,et al.  Comparative Effects of All-trans β-Carotene vs. 9-cis β-Carotene on Carcinogen-Induced Neoplastic Transformation and Connexin 43 Expression in Murine 10T1/2 Cells and on the Differentiation of Human Keratinocytes , 2000, Nutrition and cancer.

[157]  G. Rechkemmer,et al.  Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women. , 2000, The Journal of nutrition.

[158]  Walter E. Gall,et al.  4-Hydroxyretinoic Acid, a Novel Substrate for Human Liver Microsomal UDP-glucuronosyltransferase(s) and Recombinant UGT2B7* , 2000, The Journal of Biological Chemistry.

[159]  B. Sivakumar,et al.  Nutritional status affects intestinal carotene cleavage activity and carotene conversion to vitamin A in rats. , 2000, The Journal of nutrition.

[160]  Birgit R. Brandstetter,et al.  Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables , 1999, British Journal of Nutrition.

[161]  V. Böhm,et al.  Intestinal absorption of lycopene from different matrices and interactions to other carotenoids, the lipid status, and the antioxidant capacity of human plasma , 1999, European journal of nutrition.

[162]  P. Wilson,et al.  Carotenoid intakes, assessed by dietary questionnaire, are associated with plasma carotenoid concentrations in an elderly population. , 1999, The Journal of nutrition.

[163]  M. Russell,et al.  Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. , 1999, Journal of the National Cancer Institute.

[164]  L. Holmberg,et al.  Excessive Dietary Intake of Vitamin A Is Associated with Reduced Bone Mineral Density and Increased Risk for Hip Fracture , 1998, Annals of Internal Medicine.

[165]  P Borel,et al.  Low and high responders to pharmacological doses of beta-carotene: proportion in the population, mechanisms involved and consequences on beta-carotene metabolism. , 1998, Journal of lipid research.

[166]  A. Ben‐Amotz,et al.  Analysis of carotenoids with emphasis on 9-cis β-carotene in vegetables and fruits commonly consumed in Israel , 1998 .

[167]  A. Milam,et al.  Cellular retinaldehyde‐binding protein is expressed by oligodendrocytes in optic nerve and brain , 1997, Glia.

[168]  S. Schwartz,et al.  Quantification of cis-trans Isomers of Provitamin A Carotenoids in Fresh and Processed Fruits and Vegetables , 1997 .

[169]  M. Alexandre-Gouabau,et al.  Rat intestinal beta-carotene dioxygenase activity is located primarily in the cytosol of mature jejunal enterocytes. , 1996, The Journal of nutrition.

[170]  R. Parker,et al.  Evidence of cis-trans isomerization of 9-cis-beta-carotene during absorption in humans. , 1996, The American journal of clinical nutrition.

[171]  G. Omenn,et al.  Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. , 1996, The New England journal of medicine.

[172]  R. Parker Absorption, metabolism, and transport of carotenoids , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[173]  J. Saurat,et al.  Metabolism of oral 9-cis-retinoic acid in the human. Identification of 9-cis-retinoyl-beta-glucuronide and 9-cis-4-oxo-retinoyl-beta-glucuronide as urinary metabolites. , 1995, Drug metabolism and disposition: the biological fate of chemicals.

[174]  J. Goff,et al.  Identification of 9-cis,13-cis-retinoic acid as a major circulating retinoid in plasma. , 1995, Biochemistry.

[175]  R. Benya,et al.  Assessment of the intestinal retention of beta-carotene in humans. , 1994, Journal of the American College of Nutrition.

[176]  G. Folkers,et al.  The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification , 1993, Nature.

[177]  Gregor Eichele,et al.  9-cis retinoic acid is a high affinity ligand for the retinoid X receptor , 1992, Cell.

[178]  J. Grippo,et al.  9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα , 1992, Nature.

[179]  R. Evans,et al.  Nuclear receptor that identifies a novel retinoic acid response pathway , 1990, Nature.

[180]  M. Lakshman,et al.  Absorption, storage, and distribution of beta-carotene in normal and beta-carotene-fed rats: roles of parenchymal and stellate cells. , 1989, Journal of lipid research.

[181]  P. N. MacDonald,et al.  Esterification of retinol in rat liver. Possible participation by cellular retinol-binding protein and cellular retinol-binding protein II. , 1988, The Journal of biological chemistry.

[182]  Valentino J. Stella,et al.  Effects of lipid class and lipid vehicle volume on the intestinal lymphatic transport of DDT , 1986 .

[183]  C. Drevon,et al.  Lymphatic absorption and transport of retinol and vitamin D-3 from rat intestine. Evidence for different pathways. , 1984, Biochimica et biophysica acta.

[184]  R. Blomhoff,et al.  In vivo uptake of chylomicron [3H]retinyl ester by rat liver: evidence for retinol transfer from parenchymal to nonparenchymal cells. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[185]  A. Vahlquist Vitamin A in human skin: I. detection and identification of retinoids in normal epidermis. , 1982, The Journal of investigative dermatology.

[186]  G. Fex,et al.  Purification and partial characterization of a cellular retinol-binding protein from human liver. , 1982, Biochimica et biophysica acta.

[187]  D. Hollander,et al.  beta-carotene intestinal absorption: bile, fatty acid, pH, and flow rate effects on transport. , 1978, The American journal of physiology.

[188]  K. Wake DEVELOPMENT OF VITAMIN A-RICH LIPID DROPLETS IN MULTIVESICULAR BODIES OF RAT LIVER STELLATE CELLS , 1974, The Journal of cell biology.

[189]  R. Zachman,et al.  Formation and Enterohepatic Circulation of Water-soluble Metabolites of Retinol (Vitamin A) in the Rat , 1964, Nature.

[190]  R. Blomhoff,et al.  Gene expression regulation by retinoic acid , 2020 .

[191]  J. L. Napoli Functions of Intracellular Retinoid Binding-Proteins. , 2016, Sub-cellular biochemistry.

[192]  R. Rühl,et al.  Dietary regulation of adiponectin by direct and indirect lipid activators of nuclear hormone receptors. , 2016, Molecular nutrition & food research.

[193]  M. Gidley,et al.  Mastication effects on carotenoid bioaccessibility from mango fruit tissue , 2015 .

[194]  P. Besnard,et al.  From fatty-acid sensing to chylomicron synthesis: role of intestinal lipid-binding proteins. , 2014, Biochimie.

[195]  G. Duester,et al.  Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models. , 2012, Biochimica et biophysica acta.

[196]  M. Kane,et al.  Analysis, occurrence, and function of 9-cis-retinoic acid. , 2012, Biochimica et biophysica acta.

[197]  A. Palou,et al.  Lipid metabolism in mammalian tissues and its control by retinoic acid. , 2012, Biochimica et biophysica acta.

[198]  E. Harrison Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. , 2012, Biochimica et biophysica acta.

[199]  Hui Sun,et al.  Membrane receptors and transporters involved in the function and transport of vitamin A and its derivatives. , 2012, Biochimica et biophysica acta.

[200]  J. L. Napoli Physiological insights into all-trans-retinoic acid biosynthesis. , 2012, Biochimica et biophysica acta.

[201]  J. Hesketh,et al.  Single nucleotide polymorphisms upstream from the β-carotene 15,15'-monoxygenase gene influence provitamin A conversion efficiency in female volunteers. , 2012, The Journal of nutrition.

[202]  P. Chambon,et al.  Retinoid X receptor gamma signaling accelerates CNS remyelination , 2011, Nature Neuroscience.

[203]  J. Lintig,et al.  Hepatic stellate cells are an important cellular site for beta -carotene conversion to retinoid , 2011 .

[204]  L. Gluud,et al.  Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. , 2008, The Cochrane database of systematic reviews.

[205]  Béatrice Desvergne,et al.  RXR: from partnership to leadership in metabolic regulations. , 2007, Vitamins and hormones.

[206]  F. Saura-calixto,et al.  Bioaccessibility of beta-carotene, lutein, and lycopene from fruits and vegetables. , 2006, Journal of agricultural and food chemistry.

[207]  A. Nagao Oxidative conversion of carotenoids to retinoids and other products. , 2004, The Journal of nutrition.

[208]  A. Ross,et al.  Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. , 2004, The Journal of nutrition.

[209]  R. Russell,et al.  Beta-carotene and beta-apo-14'-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cells. , 2004, The Journal of nutrition.

[210]  P. Grolier,et al.  Feedback regulation of beta,beta-carotene 15,15'-monooxygenase by retinoic acid in rats and chickens. , 2002, The Journal of nutrition.

[211]  A. Catharine Retinol Esterification by Rat Liver Microsomes EVIDENCE FOR A FATTY ACYL COENZYME A : RETINOL ACYLTRANSFERASE * , 2001 .

[212]  V. Konovalov,et al.  AM1, INDO/S and optical studies of carbocations of carotenoid molecules. Acid induced isomerization , 1999 .

[213]  A. Barua Retinoyl beta-glucuronide: a biologically active form of vitamin A. , 1997, Nutrition reviews.

[214]  P. Borel,et al.  In vitro and in vivo inhibition of beta-carotene dioxygenase activity by canthaxanthin in rat intestine. , 1997, Archives of biochemistry and biophysics.

[215]  W. Schreurs,et al.  In vitro measurement of beta-carotene cleavage activity: methodological considerations and the effect of other carotenoids on beta-carotene cleavage. , 1996, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[216]  T. van Vliet,et al.  beta-Carotene absorption and cleavage in rats is affected by the vitamin A concentration of the diet. , 1996, The Journal of nutrition.

[217]  P. Chambon,et al.  Biologic activities of retinoic acid and 3,4-didehydroretinoic acid in human keratinocytes are similar and correlate with receptor affinities and transactivation properties. , 1994, The Journal of investigative dermatology.

[218]  P Chambon,et al.  Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[219]  M. Petkovich Regulation of gene expression by vitamin A: the role of nuclear retinoic acid receptors. , 1992, Annual review of nutrition.

[220]  X. D. Wang,et al.  Enzymatic conversion of beta-carotene into beta-apo-carotenals and retinoids by human, monkey, ferret, and rat tissues. , 1991, Archives of biochemistry and biophysics.

[221]  K. Wake Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs. , 1980, International review of cytology.

[222]  P. A. Peterson Characteristics of a vitamin A-transporting protein complex occurring in human serum. , 1971, The Journal of biological chemistry.

[223]  R. D. Zachman,et al.  Biliary secretion of metabolites of retinol and of retinoic acid in the guinea pig and chick. , 1966, The Journal of nutrition.