Taking electrons out of bioelectronics: bioprotonic memories, transistors, and enzyme logic

The ability of bioelectronic devices to conduct protons and other ions opens up opportunities to interface with biology. In this research highlight, we report on our recent efforts in bioprotonic devices. These devices monitor and modulate a current of protons with an applied voltage. Voltage-controlled proton flow mimics semiconductor devices with complementary transistors or biological behaviors such as synaptic-like memories and enzyme logic.

[1]  T. DeCoursey.  Voltage‐gated proton channels: what's next? , 2008, The Journal of physiology.

[2]  Jian Zhou,et al.  Switchable electrode controlled by Boolean logic gates using enzymes as input signals. , 2009, Bioelectrochemistry.

[3]  L. Glasser.  Proton conduction and injection in solids , 1975 .

[4]  Rylan Kautz,et al.  Two‐Terminal Protonic Devices with Synaptic‐Like Short‐Term Depression and Device Memory , 2014, Advanced materials.

[5]  G. Szabó,et al.  Gramicidin forms multi-state rectifying channels , 1981, Nature.

[6]  Magnus Berggren,et al.  Ion bipolar junction transistors , 2010, Proceedings of the National Academy of Sciences.

[7]  M. Eigen,et al.  Self-dissociation and protonic charge transport in water and , 1958, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.

[8]  Jan Halámek,et al.  Responsive interface switchable by logically processed physiological signals: toward "smart" actuators for signal amplification and drug delivery. , 2011, ACS applied materials & interfaces.

[9]  Erik E. Josberger,et al.  An enzyme logic bioprotonic transducer , 2015 .

[10]  M. Berggren,et al.  Electrocardiographic Recording with Conformable Organic Electrochemical Transistor Fabricated on Resorbable Bioscaffold , 2014, Advanced materials.

[11]  M. Dyer,et al.  pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1. , 2011, Trends in cell biology.

[12]  Evgeny Katz,et al.  Switchable electrode controlled by enzyme logic network system: approaching physiologically regulated bioelectronics. , 2009, Journal of the American Chemical Society.

[13]  Gaetano Scamarcio,et al.  Interfacial electronic effects in functional biolayers integrated into organic field-effect transistors , 2012, Proceedings of the National Academy of Sciences.

[14]  Narayan Srinivasa,et al.  A functional hybrid memristor crossbar-array/CMOS system for data storage and neuromorphic applications. , 2012, Nano letters.

[15]  A. Bunge,et al.  Progress toward a solid-state ionic field effect transistor , 2012 .

[16]  S. Caplan,et al.  Bacterial flagellar motor and H(+)/ATP synthase: two proton-driven rotary molecular devices with different functions. , 2002, Bioelectrochemistry.

[17]  Magnus Berggren,et al.  Organic bioelectronics in nanomedicine. , 2011, Biochimica et biophysica acta.

[18]  A. Place,et al.  Voltage-gated proton channel in a dinoflagellate , 2011, Proceedings of the National Academy of Sciences.

[19]  George G. Malliaras,et al.  Organic Electronics at the Interface with Biology , 2010 .

[20]  Thomas Frauenheim,et al.  "Proton holes" in long-range proton transfer reactions in solution and enzymes: A theoretical analysis. , 2006, Journal of the American Chemical Society.

[21]  H. Morowitz,et al.  Theory of hydrogen bonded chains in bioenergetics , 1980 .

[22]  Young Jo Kim,et al.  Self-deployable current sources fabricated from edible materials. , 2013, Journal of materials chemistry. B.

[23]  C. Grigoropoulos,et al.  Bioelectronic silicon nanowire devices using functional membrane proteins , 2009, Proceedings of the National Academy of Sciences.

[24]  T. DeCoursey,et al.  Aspartate112 is the Selectivity Filter of the Human Voltage Gated Proton Channel , 2011, Nature.

[25]  T. DeCoursey.  Voltage-gated proton channels and other proton transfer pathways. , 2003, Physiological reviews.

[26]  Erik E. Josberger,et al.  Protonic and Electronic Transport in Hydrated Thin Films of the Pigment Eumelanin , 2015 .

[27]  Nipun Misra,et al.  Carbon nanotube transistor controlled by a biological ion pump gate. , 2010, Nano letters.

[28]  C. Krarup,et al.  Cerebral gray and white matter changes and clinical course in metachromatic leukodystrophy , 2012, Neurology.

[29]  P. Meredith,et al.  Electronic and optoelectronic materials and devices inspired by nature , 2013, Reports on progress in physics. Physical Society.

[30]  S. Cukierman,et al.  Et tu, Grotthuss! and other unfinished stories. , 2006, Biochimica et biophysica acta.

[31]  Chao Zhong,et al.  A polysaccharide bioprotonic field-effect transistor. , 2011, Nature communications.

[32]  A. Gorodetsky,et al.  Protonic transistors from thin reflectin films , 2015 .

[33]  P. Mitchell.  CHEMIOSMOTIC COUPLING IN OXIDATIVE AND PHOTOSYNTHETIC PHOSPHORYLATION , 1966, Biological reviews of the Cambridge Philosophical Society.

[34]  Clara Santato,et al.  New opportunities for organic electronics and bioelectronics: ions in action , 2013 .

[35]  R. Pethig,et al.  A proton-injecting technique for the measurement of hydration-dependent protonic conductivity , 1986 .

[36]  L. Torsi,et al.  Tailoring Functional Interlayers in Organic Field‐Effect Transistor Biosensors , 2015, Advanced materials.

[37]  Charles M. Lieber,et al.  Design and synthesis of diverse functional kinked nanowire structures for nanoelectronic bioprobes. , 2013, Nano letters.

[38]  Alon A Gorodetsky,et al.  Bulk protonic conductivity in a cephalopod structural protein. , 2014, Nature chemistry.

[39]  Jian Zhou,et al.  Coupling of Biocomputing Systems with Electronic Chips: Electronic Interface for Transduction of Biochemical Information , 2009 .

[40]  M. Rolandi.  Bioelectronics: A positive future for squid proteins. , 2014, Nature chemistry.

[41]  Evgeny Katz,et al.  Integration of biomolecular logic gates with field-effect transducers , 2011 .

[42]  Graeme R. Hanson,et al.  Role of semiconductivity and ion transport in the electrical conduction of melanin , 2012, Proceedings of the National Academy of Sciences.

[43]  Robert Forchheimer,et al.  Logic Gates Based on Ion Transistors , 2022 .

[44]  H J Morowitz,et al.  Molecular mechanisms for proton transport in membranes. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[45]  E. Katz,et al.  Enzyme logic AND-Reset and OR-Reset gates based on a field-effect electronic transducer modified with multi-enzyme membrane. , 2015, Chemical communications.