Bilayer hydrogel assembly

The combination of two hydrogel layers based on photo-cross-linkable poly(dimethyl acrylamide) (PDMAAm) as base layer and poly(N-isopropyl acrylamide) (PNIPAAm) as top layer forms a bilayer assembly where, the base layer is highly swollen and the top layer shows temperature responsive swelling. Characterization was done by a combination of surface plasmon resonance spectroscopy and optical waveguide spectroscopy as well as atomic force microscopy. The PDMAAm and PNIPAAm within the bilayer assembly retain their swelling behavior, which they showed as a separate layer. Due to the presence of the photo-cross-linker such bilayer films can be patterned to develop surfaces with different properties at different regions.

[1]  Anthony Guiseppi-Elie,et al.  Release characteristics of novel pH-sensitive p(HEMA-DMAEMA) hydrogels containing 3-(trimethoxy-silyl) propyl methacrylate. , 2003, Biomacromolecules.

[2]  T. Okano,et al.  Copolymerization of 2-carboxyisopropylacrylamide with N-isopropylacrylamide accelerates cell detachment from grafted surfaces by reducing temperature. , 2003, Biomacromolecules.

[3]  Andreas Richter,et al.  Electronically controllable microvalves based on smart hydrogels: magnitudes and potential applications , 2003 .

[4]  M. Plötner,et al.  Photopatterning of thermally sensitive hydrogels useful for microactuators , 1999 .

[5]  H. Adler,et al.  Preparation of thermosensitive nanogels by photo-cross-linking , 2002 .

[6]  Allan S Hoffman,et al.  Hydrogels for biomedical applications. , 2002, Advanced drug delivery reviews.

[7]  C. Frank,et al.  Photo-Cross-Linkable PNIPAAm Copolymers. 4. Effects of Copolymerization and Cross-Linking on the Volume-Phase Transition in Constrained Hydrogel Layers , 2003 .

[8]  Igor Luzinov,et al.  Mixed polymer brushes by sequential polymer addition: anchoring layer effect. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[9]  C. Frank,et al.  Photo-Cross-Linkable PNIPAAm Copolymers. 1. Synthesis and Characterization of Constrained Temperature-Responsive Hydrogel Layers , 2002 .

[10]  Allon I Hochbaum,et al.  Rational design of cytophilic and cytophobic polyelectrolyte multilayer thin films. , 2003, Biomacromolecules.

[11]  J. Schlenoff,et al.  Protein adsorption modalities on polyelectrolyte multilayers. , 2004, Biomacromolecules.

[12]  Karl-Friedrich Arndt,et al.  Photo cross-linkable poly(N-isopropylacrylamide) copolymers III: micro-fabricated temperature responsive hydrogels , 2003 .

[13]  W. Knoll,et al.  Interfaces and thin films as seen by bound electromagnetic waves. , 1998, Annual review of physical chemistry.

[14]  Franco Cerrina,et al.  Guided Self-Assembly of Symmetric Diblock Copolymer Films on Chemically Nanopatterned Substrates , 2000 .

[15]  A. Hoffman.  Bioconjugates of intelligent polymers and recognition proteins for use in diagnostics and affinity separations. , 2000, Clinical chemistry.

[16]  J. Schlenoff,et al.  Recent developments in the properties and applications of polyelectrolyte multilayers , 2006 .

[17]  K. Br,et al.  Current status of DNA vaccines in veterinary medicine. , 2000 .

[18]  D. Brooks,et al.  Molecular weight and polydispersity estimation of adsorbing polymer brushes by atomic force microscopy. , 2004, Langmuir : the ACS journal of surfaces and colloids.