Comparative analysis of primary and secondary glomerulopathies in the northeast of Brazil: data from the Pernambuco Registry of Glomerulopathies - REPEG.

INTRODUCTION In Brazil, glomerulopathies are the third leading cause of chronic renal disease, accounting for 11% of dialysis patients. Studies on the prevalence of this disease in Northeastern Brazil are scarce. OBJECTIVE The aim was to describe the findings of biopsies and to conduct a comparative analysis on the clinical laboratory presentation of primary glomerulopathies (PG) and secondary glomerulopathies (SG). METHODS This was a retrospective study conducted at two public teaching hospitals in the state of Pernambuco, Northeastern Brazil. RESULTS A total of 1151 biopsies performed between 1998 and 2016 were analyzed. The sample consisted of 670 biopsies of native kidneys, after excluding extra glomerular diseases and unsuitable material. PG were more frequent than SG (58% vs. 42%). There was a prevalence among PG of focal segmental glomerulosclerosis (43%). Membranoproliferative glomerulonephritis and collapsing glomerulopathy, accounted for 9% and 3% of the PG, respectively. For SG, the main etiologies were lupus nephritis (67%) and infections (10%). Female sex, hematuria and an elevated level of creatinine were related to a greater chance of SG, at multivariate analysis. An increase of proteinuria reduced this chance. Nephrotic syndrome was more common among the PG, while urinary abnormalities and nephritic syndrome prevailed in patients with SG. CONCLUSION This is the first registry of glomerulopathies in Northeastern Brazil. It also presents a comparative analysis of the main clinical laboratory abnormalities of PG and SG, and includes the current classifications of glomerular diseases.

[1]  M. M. Nascimento,et al.  Frequency and clinical histological analysis of glomerular diseases in a tertiary hospital in southern Brazil. , 2016, Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.

[2]  R. Côrrea,et al.  Clinical and epidemiological prevalence of glomerulopathies elderly in the city of Uberaba - MG. , 2015, Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.

[3]  R. Guimarães,et al.  A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil. , 2015, Genetics and Molecular Research.

[4]  Venice Chávez Valencia,et al.  [Epidemiology of glomerular disease in adults: a database review]. , 2014, Gaceta medica de Mexico.

[5]  A. Lupo,et al.  Incidence of primary glomerulonephritis in a large North-Eastern Italian area: a 13-year renal biopsy study. , 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[6]  Y. Kiyohara,et al.  Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010 , 2013, Clinical and Experimental Nephrology.

[7]  M. Sipahioğlu,et al.  Comparison of the Clinical and Laboratory Presentations of Primary and Secondary Glomerular Diseases , 2011, Renal failure.

[8]  F. Fervenza,et al.  Membranoproliferative glomerulonephritis: pathogenetic heterogeneity and proposal for a new classification. , 2011, Seminars in nephrology.

[9]  M. Galvão,et al.  Collapsing glomerulopathy in Portugal: a review of the histological and clinical findings in HIV and non-HIV patients. , 2011, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[10]  K. vanden Houte,et al.  RENAL BIOPSY FINDINGS IN BELGIUM: A RETROSPECTIVE SINGLE CENTER ANALYSIS , 2011, Acta clinica Belgica.

[11]  C. Martins,et al.  Profile of glomerular diseases in a public hospital of Federal District, Brazil. , 2010, Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.

[12]  G. Kirsztajn,et al.  An overview on frequency of renal biopsy diagnosis in Brazil: clinical and pathological patterns based on 9,617 native kidney biopsies. , 2010, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[13]  R. Naumovic,et al.  Renal biopsy registry from a single centre in Serbia: 20 years of experience. , 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[14]  J. Rodelo,et al.  Glomerular diseases in a Hispanic population: review of a regional renal biopsy database. , 2009, Sao Paulo medical journal = Revista paulista de medicina.

[15]  H. Schnaper,et al.  A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases. , 2007, Clinical journal of the American Society of Nephrology : CJASN.

[16]  R. T. Barros,et al.  Paulista Registry of glomerulonephritis: 5-year data report. , 2006, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[17]  Eric J Bergstralh,et al.  Changing incidence of glomerular disease in Olmsted County, Minnesota: a 30-year renal biopsy study. , 2006, Clinical journal of the American Society of Nephrology : CJASN.

[18]  O. Noboa,et al.  [Frequency of diagnosis and clinic presentation of glomerulopathies in Uruguay]. , 2005, Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.

[19]  V. Tesar,et al.  The Czech registry of renal biopsies. Occurrence of renal diseases in the years 1994-2000. , 2004, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[20]  Zhi-Hong Liu,et al.  Epidemiologic data of renal diseases from a single unit in China: analysis based on 13,519 renal biopsies. , 2004, Kidney international.

[21]  J. López-Gómez,et al.  Clinicopathologic correlations of renal pathology in Spain. , 2004, Kidney international.

[22]  L. Gesualdo,et al.  The Italian experience of the national registry of renal biopsies. , 2004, Kidney international.

[23]  L. Grcevska,et al.  Collapsing glomerulopathy: clinical characteristics and follow-up. , 1999, American journal of kidney diseases : the official journal of the National Kidney Foundation.