Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012
暂无分享,去创建一个
J. Barbosa-Filho | B. Lira | P. D. DE ATHAYDE-FILHO | Cledualdo Soares de Oliveira | J. G. F. Lorenzo
[1] C. Kazak,et al. Design and One‐Pot and Microwave‐Assisted Synthesis of 2‐Amino/5‐Aryl‐1,3,4‐oxadiazoles Bearing a Benzimidazole Moiety as Antioxidants , 2012, Archiv der Pharmazie.
[2] M. B. Kalashetti,et al. Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring. , 2012, European journal of medicinal chemistry.
[3] B. Poojary,et al. Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents. , 2012, European journal of medicinal chemistry.
[4] B. Ahmed,et al. 1,3,4-oxadiazole: a biologically active scaffold. , 2012, Mini reviews in medicinal chemistry.
[5] Andrew G. Leach,et al. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. , 2012, Bioorganic & medicinal chemistry letters.
[6] J. Barbosa-Filho,et al. Synthesis, Molecular Properties Prediction, and Anti-staphylococcal Activity of N-Acylhydrazones and New 1,3,4-Oxadiazole Derivatives , 2012, Molecules.
[7] Daohang He,et al. Synthesis and optical properties of novel anthracene-based stilbene derivatives containing an 1,3,4-oxadiazole unit , 2012 .
[8] Y. Geng,et al. Hydroxyl may not be indispensable for raltegravir: Design, synthesis and SAR Studies of raltegravir derivatives as HIV-1 inhibitors. , 2012, European journal of medicinal chemistry.
[9] Kazuo Kitaura,et al. Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds. , 2012, Journal of medicinal chemistry.
[10] C. Kappe,et al. High-temperature continuous flow synthesis of 1,3,4-oxadiazoles via N-acylation of 5-substituted tetrazoles , 2012 .
[11] F. Badria,et al. Synthesis and antitumor evaluation of some new 1,3,4-oxadiazole-based heterocycles. , 2012, European journal of medicinal chemistry.
[12] Hui Yu,et al. A Novel One‐Pot Synthesis of α‐Keto‐1,3,4‐oxadiazole Derivatives Based on Isocyanide‐Nef Reaction. , 2012 .
[13] J. Serrano,et al. Liquid Crystalline Ionic Dendrimers Containing Luminescent Oxadiazole Moieties , 2012 .
[14] Jonas Boström,et al. Oxadiazoles in medicinal chemistry. , 2012, Journal of medicinal chemistry.
[15] J. Paquin,et al. Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent. , 2012, Organic & biomolecular chemistry.
[16] A. Kudelko,et al. Microwave-assisted synthesis of 2-styryl-1,3,4-oxadiazoles from cinnamic acid hydrazide and triethyl orthoesters , 2012 .
[17] S. Gattani,et al. Identification and development of 2,5-disubstituted oxadiazole as potential candidate for treatment of XDR and MDR tuberculosis. , 2012, European journal of medicinal chemistry.
[18] O. Ali,et al. Synthesis and Antimicrobial Activity of New 2,5‐Disubstituted 1,3,4‐Oxadiazoles and 1,2,4‐Triazoles and Their Sugar Derivatives , 2012 .
[19] Kai Liu,et al. Synthesis, molecular modeling and biological evaluation of 2-(benzylthio)-5-aryloxadiazole derivatives as anti-tumor agents. , 2012, European journal of medicinal chemistry.
[20] P. Kumari,et al. Synthesis of coumarin-based 1,3,4-oxadiazol-2ylthio-N-phenyl/benzothiazolyl acetamides as antimicrobial and antituberculosis agents , 2012, Medicinal Chemistry Research.
[21] P. Kumari,et al. Synthesis of novel 3-(5-sulfanyl-1,3,4-oxadiazol-2-yl)-2H-chromen-2-one condensed s-triazinyl piperazines and piperidines as antimicrobial agents , 2012, Medicinal Chemistry Research.
[22] Bruce J. Melancon,et al. The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. , 2011, ACS chemical neuroscience.
[23] J. Kunitomo,et al. A novel glycogen synthase kinase‐3 inhibitor 2‐methyl‐5‐(3‐{4‐[(S )‐methylsulfinyl]phenyl}‐1‐benzofuran‐5‐yl)‐1,3,4‐oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer’s disease , 2011, Journal of neurochemistry.
[24] Yan-Bin Zhang,et al. Synthesis, biological evaluation, and molecular docking studies of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents. , 2011, Bioorganic & medicinal chemistry.
[25] Jian Wang,et al. Synthesis and Antifungal Activity of Novel Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties , 2011, Molecules.
[26] P. Zhan,et al. 1,3,4-oxadiazole: a privileged structure in antiviral agents. , 2011, Mini reviews in medicinal chemistry.
[27] Hui Yu,et al. A novel one-pot synthesis of α-keto-1,3,4-oxadiazole derivatives based on isocyanide-Nef reaction , 2011 .
[28] T. Ghosh,et al. Cu(II) catalyzed imine C-H functionalization leading to synthesis of 2,5-substituted 1,3,4-oxadiazoles. , 2011, Organic letters.
[29] R. Veerasamy,et al. 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors. , 2011, Bioorganic & medicinal chemistry letters.
[30] A. Monkman,et al. Bipolar molecules with high triplet energies: synthesis, photophysical, and structural properties. , 2011, The Journal of organic chemistry.
[31] A. Ramazani,et al. The reaction of (N‐isocyanimino) triphenylphosphorane with (E)‐3‐aryl‐2‐ propenoic acid derivatives: One‐pot synthesis of 2‐[(E)‐2‐aryl‐1‐ethenyl]‐1,3,4‐oxadiazoles via intramolecular aza‐Wittig reaction , 2011 .
[32] Lingzhou Zhao,et al. Molecular Modeling Studies on Benzimidazole Carboxamide Derivatives as PARP‐1 Inhibitors Using 3D‐QSAR and Docking , 2011, Chemical biology & drug design.
[33] Rajnish Kumar,et al. Synthesis, antibacterial evaluation and QSAR studies of 7-[4-(5-aryl-1,3,4-oxadiazole-2-yl)piperazinyl] quinolone derivatives. , 2011, European journal of medicinal chemistry.
[34] Z. Kaplancıklı. Synthesis of Some Oxadiazole Derivatives as New Anticandidal Agents , 2011, Molecules.
[35] P. Mátyus,et al. 3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: a new scaffold for the selective inhibition of monoamine oxidase B. , 2011, Journal of medicinal chemistry.
[36] A. Ramazani,et al. One‐Pot, Four‐Component Synthesis of Fully Substituted 1,3,4‐Oxadiazole Derivatives from (Isocyanoimino)triphenylphosphorane, a Primary Amine, an Aromatic Carboxylic Acid, and Chloroacetone , 2011 .
[37] A. Ramazani,et al. One-Pot Efficient Synthesis of Fully Substituted 1,3,4-Oxadiazole Derivatives from (N-Isocyanimino)triphenylphosphorane, Carboxylic Acids, and Aromatic Bis-Aldehydes , 2011 .
[38] B. Ma,et al. Novel Cytochrome P450-Mediated Ring Opening of the 1,3,4-Oxadiazole in Setileuton, a 5-Lipoxygenase Inhibitor , 2011, Drug Metabolism and Disposition.
[39] T. Farghaly,et al. Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents. , 2011, Acta poloniae pharmaceutica.
[40] A. Dadras,et al. Synthesis and herbicidal activity of novel 5-chloro-3-fluoro-2-phenoxypyridines with a 1,3,4-oxadiazole ring , 2011 .
[41] A. Ramazani,et al. The Reaction of (N‐Isocyanimino)triphenylphosphorane with Biacetyl in the Presence of Aromatic Carboxylic Acids: Efficient One‐Pot Three‐Component Reaction for the Synthesis of 3‐(5‐Aryl‐1,3,4‐oxadiazol‐2‐yl)‐3‐hydroxybutan‐2‐one Derivatives , 2011 .
[42] B. Lotfi,et al. Electrocyclization of Semicarbazone; A Novel Route of Green Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazoles , 2011 .
[43] S. Kiran. 1, 3, 4 OXADIAZOLE: A POTENT DRUG CANDIDATE WITH VARIOUS PHARMACOLOGICAL ACTIVITIES , 2011 .
[44] S. Gaonkar,et al. Microwave-Assisted Solution Phase Synthesis of Novel 2-{4-[2-(N-Methyl-2-pyridylamino)ethoxy]phenyl}-5-Substituted 1,3,4-Oxadiazole Library , 2011 .
[45] A. Chabukswar,et al. Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents. , 2011, Bioorganic & medicinal chemistry letters.
[46] S. Kashaw,et al. Synthesis, anticonvulsant and neurotoxic activity of some new 2,5-disubstituted-1,3,4-oxadiazoles , 2011, Medicinal Chemistry Research.
[47] A. Ramazani,et al. A novel four-component reaction for the synthesis of disubstituted 1,3,4-oxadiazole derivatives , 2011, Molecular Diversity.
[48] M. Abdollahi,et al. Synthesis and analgesic activity of new 1,3,4-oxadiazoles and 1,2,4-triazoles , 2011, Medicinal Chemistry Research.
[49] Ravi S. Lamani,et al. A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids , 2010 .
[50] Abdul Samad,et al. Molecular properties prediction, synthesis and antimicrobial activity of some newer oxadiazole derivatives. , 2010, European journal of medicinal chemistry.
[51] M. Khanfar,et al. Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. , 2010, Journal of medicinal chemistry.
[52] J. Keshavayya,et al. Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol-2-yl methyl)] phthalazin-1(2H)-one derivatives. , 2010, European journal of medicinal chemistry.
[53] M. Yamada,et al. Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine] analogs. , 2010, European journal of medicinal chemistry.
[54] P. L. Lobo,et al. Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives. , 2010, European journal of medicinal chemistry.
[55] A. Jadhav,et al. Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. , 2010, Journal of medicinal chemistry.
[56] A. Malikzay,et al. Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor. , 2010, Translational oncology.
[57] B. Kalluraya,et al. Synthesis and biological property of some novel 1,3,4-oxadiazoles. , 2010, European journal of medicinal chemistry.
[58] N. Siddiqui,et al. Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid. , 2010, Bioorganic & medicinal chemistry letters.
[59] P. Mishra,et al. Novel semicarbazones based 2,5-disubstituted-1,3,4-oxadiazoles: one more step towards establishing four binding site pharmacophoric model hypothesis for anticonvulsant activity. , 2010, Bioorganic & medicinal chemistry letters.
[60] Kenji Matsuno,et al. Identification of a New Series of STAT3 Inhibitors by Virtual Screening. , 2010, ACS medicinal chemistry letters.
[61] K. Bothara,et al. Design, synthesis, and evaluation of anti-inflammatory, analgesic, ulcerogenicity, and nitric oxide releasing studies of novel indomethacin analogs as non-ulcerogenic derivatives , 2010, Journal of enzyme inhibition and medicinal chemistry.
[62] Monica Sharma,et al. Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles. , 2010, European journal of medicinal chemistry.
[63] I. Davies,et al. A practical synthesis of 5-lipoxygenase inhibitor MK-0633. , 2010, The Journal of organic chemistry.
[64] A. Ramazani,et al. Novel one-pot, four-component condensation reaction: an efficient approach for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives by a Ugi-4CR/aza-Wittig sequence. , 2010, Organic letters.
[65] V. Bobade,et al. N-Chlorosuccinimide/1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)–Mediated Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles , 2010 .
[66] R. Somani,et al. Studies of CNS Activities of Some Mannich bases of 1,3,4-Oxadiazole , 2010 .
[67] S. Lata,et al. Synthesis of substituted acridinyl pyrazoline derivatives and their evaluation for anti-inflammatory activity. , 2010, European journal of medicinal chemistry.
[68] G. V. Suresh Kumar,et al. Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. , 2010, European journal of medicinal chemistry.
[69] J. Patel,et al. Synthesis and Antimicrobial Activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones , 2010, Scientia pharmaceutica.
[70] Christine Brideau,et al. The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor. , 2010, ACS medicinal chemistry letters.
[71] P. Shetty,et al. Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety. , 2010, European journal of medicinal chemistry.
[72] S. Singh,et al. Electrochemical synthesis of 5-substituted-2-amino (substituted amino)-1,3,4-oxadiazoles at the platinum electrode , 2010 .
[73] P. G. Nayak,et al. A possible correlation between the correction of endothelial dysfunction and normalization of high blood pressure levels by 1,3,4-oxadiazole derivative, an L-type Ca2+ channel blocker in deoxycorticosterone acetate and N(G)-nitro-l-arginine hypertensive rats. , 2010, Chemico-biological interactions.
[74] M. Yamada,et al. Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine]. , 2010, Bioorganic & medicinal chemistry letters.
[75] Ryan S. Davis,et al. Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4. , 2010, Journal of medicinal chemistry.
[76] N. Siddiqui,et al. Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide , 2010 .
[77] A. Ramazani,et al. The reaction of (N‐isocyanimino) triphenylphosphorane with an electron‐poor α‐haloketone in the presence of aromatic carboxylic acids: A novel three‐component reaction for the synthesis of disubstituted 1,3,4‐oxadiazole derivatives , 2010 .
[78] J. Carvalho,et al. Synthesis, antitumor and antimicrobial activity of novel 1-substituted phenyl-3-[3-alkylamino(methyl)-2-thioxo-1,3,4-oxadiazol-5-yl] β-carboline derivatives , 2010 .
[79] S. Bala,et al. Heterocyclic 1, 3, 4-oxadiazole compounds with diverse biological activities: A comprehensive review , 2010 .
[80] Sanjeev Kumar. ANODIC SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL 2-AMINO-5-SUBSTITUTED-1,3,4-OXADIAZOLES , 2010 .
[81] I. H. Tomi,et al. Synthesis, characterization and effect of bis-1,3,4- oxadiazole rings containing glycine moiety on the activity of some transferase enzymes , 2010 .
[82] P. Mishra,et al. Anticonvulsant and sedative-hypnotic activity of some novel 3-[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2-styrylquinazoline-4(3H)-ones , 2010, Medicinal Chemistry Research.
[83] F. Attaby,et al. Anti-Alzheimer and Anti-Cox-2 Activities of the Newly Synthesized 2,3′-Bipyridine Derivatives (I) , 2009 .
[84] M. M. Elsayed,et al. Anti-Alzheimer and Anti-COX-2 Activities of the Newly Synthesized 2,3′-Bipyridine Derivatives (II) , 2009 .
[85] S. R. Shukla,et al. Synthesis and antibacterial activity of some novel bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and bis-4-thiazolidinone derivatives from terephthalic dihydrazide. , 2009, European journal of medicinal chemistry.
[86] Martin J. Stoermer,et al. In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses. , 2009, Antiviral research.
[87] Changkun Li,et al. A mild, one-pot preparation of 1,3,4-oxadiazoles , 2009 .
[88] P. G. Nayak,et al. Vasorelaxant effect in rat aortic rings through calcium channel blockage: a preliminary in vitro assessment of a 1,3,4-oxadiazole derivative. , 2009, Chemico-biological interactions.
[89] O. Aly,et al. Design, synthesis and hypolipidemic activity of novel 2-(naphthalen-2-yloxy)propionic acid derivatives as desmethyl fibrate analogs. , 2009, European journal of medicinal chemistry.
[90] B. Jayashankar,et al. Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents. , 2009, European journal of medicinal chemistry.
[91] J. Kunitomo,et al. 2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability. , 2009, Journal of medicinal chemistry.
[92] A. Husain,et al. Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents. , 2009, European journal of medicinal chemistry.
[93] R. Vaickelionienė,et al. Synthesis of substituted 1,3,4-oxadiazole derivatives , 2009 .
[94] M. Akhter,et al. Aroylpropionic acid based 2,5-disubstituted-1,3,4-oxadiazoles: synthesis and their anti-inflammatory and analgesic activities. , 2009, European journal of medicinal chemistry.
[95] Vijender Singh,et al. Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides , 2009, Molecules.
[96] I. Baciu,et al. Convenient preparation of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles promoted by Dess-Martin reagent , 2009 .
[97] E. Garvey,et al. 1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position. , 2009, Bioorganic & medicinal chemistry letters.
[98] J. Kunitomo,et al. Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. , 2009, Bioorganic & medicinal chemistry.
[99] N. James,et al. Zibotentan endothelin ETA receptor antagonist oncolytic , 2009 .
[100] C. S. Rajput,et al. Synthesis and anti-inflammatory activity of newer quinazolin-4-one derivatives. , 2009, European journal of medicinal chemistry.
[101] H. Kumar,et al. 1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: synthesis and preliminary evaluation of biological properties. , 2008, European journal of medicinal chemistry.
[102] T. V. Artamonova,et al. Tetrazoles: LIII. Microwave-activated acylation of 5-substituted tetrazoles , 2008 .
[103] D. Pore,et al. Trichloroisocyanuric Acid–Mediated One-Pot Synthesis of Unsymmetrical 2,5-Disubstituted 1,3,4-Oxadiazoles at Ambient Temperature , 2008 .
[104] E. El‐Ashry,et al. Synthesis and Antiviral Evaluation of Novel 5-(N-Arylaminomethyl-1,3,4-oxadiazol-2-yl)hydrazines and Their Sugars, 12,4-Triazoles, Tetrazoles and Pyrazolyl Derivatives. , 2008 .
[105] D. Boger,et al. Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. , 2008, Journal of medicinal chemistry.
[106] Mohamed Ashraf Ali,et al. anti-HAV Activity of Some Newly Synthesized Triazolo[4,3-b]pyridazines. , 2008 .
[107] Qiong Chen,et al. Syntheses of Diheterocyclic Compounds Based on 2-Thioacetohydrazide-5,7-dimethyl-1,2,4-triazolo[1,5-a]-pyrimidine , 2008, Molecules.
[108] R. Varma,et al. Greener and Rapid Access to Bioactive Heterocycles: One-Pot Solvent-Free Synthesis of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles. , 2008 .
[109] C. Draghici,et al. Synthesis and Biological Evaluation of Various New Substituted 1,3,4-oxadiazole-2-thiols , 2008 .
[110] E. El‐Ashry,et al. Synthesis and Antiviral Evaluation of Novel 5‐(N‐Aryl‐aminomethyl‐1,3,4‐oxadiazol‐2‐yl)hydrazines and Their Sugars, 1,2,4‐Triazoles, Tetrazoles and Pyrazolyl Derivatives , 2008, Archiv der Pharmazie.
[111] Z. Temesgen,et al. Raltegravir: first in class HIV integrase inhibitor , 2008, Therapeutics and clinical risk management.
[112] R. Varma,et al. Greener and rapid access to bio-active heterocycles: one-pot solvent-free synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles , 2008 .
[113] Zheng Li,et al. Silica-Supported Dichlorophosphate: a Recoverable Cyclodehydrant for the Eco-Friendly Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles under Solvent-Free and Microwave Irradiation Conditions , 2008 .
[114] P. Mishra,et al. Synthesis and antimicrobial activity of some new 3–[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2- styrylquinazoline-4(3H)-ones , 2008, Medicinal Chemistry Research.
[115] Ilkay Küçükgüzel,et al. Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents. , 2007, European journal of medicinal chemistry.
[116] Mohamed Ashraf Ali,et al. Oxadiazole mannich bases: synthesis and antimycobacterial activity. , 2007, Bioorganic & medicinal chemistry letters.
[117] A. Ramazani,et al. The Reaction of (N‐Isocyanimino)triphenylphosphorane with Benzoic Acid Derivatives: A Novel Synthesis of 2‐Aryl‐1,3,4‐oxadiazole Derivatives. , 2007 .
[118] Pamela J. Martin,et al. Hydrogen‐bonded oxadiazole mesogens , 2007 .
[119] M. Amir,et al. Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation properties of ibuprofen derivatives , 2007, Acta pharmaceutica.
[120] M. Ali,et al. Synthesis and Anti Tuberculostatic Activity of Novel 1,3,4‐Oxadiazole Derivatives , 2007 .
[121] A. Kadi,et al. Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles and 2-(1-adamantylamino)-5-substituted-1,3,4-thiadiazoles. , 2007, European journal of medicinal chemistry.
[122] C. Supuran,et al. Synthesis and antimalarial activity of novel chiral and achiral benzenesulfonamides bearing 1, 3, 4-oxadiazole moieties , 2007, Journal of enzyme inhibition and medicinal chemistry.
[123] A. Shafiee,et al. Synthesis, anticonvulsant and muscle relaxant activities of substituted 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole , 2007 .
[124] A. Savarino. A historical sketch of the discovery and development of HIV-1 integrase inhibitors , 2006, Expert opinion on investigational drugs.
[125] I. Davies,et al. Superior reactivity of thiosemicarbazides in the synthesis of 2-amino-1,3,4-oxadiazoles. , 2006, The Journal of organic chemistry.
[126] M. Dabiri,et al. A facile procedure for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles , 2006 .
[127] D. Kelley,et al. One pot direct synthesis of oxazolines, benzoxazoles, and oxadiazoles from carboxylic acids using the Deoxo-Fluor reagent , 2006 .
[128] Thiam Hong Ang,et al. Synthesis and the biological evaluation of 2-benzenesulfonylalkyl-5-substituted-sulfanyl-[1,3,4]-oxadiazoles as potential anti-hepatitis B virus agents. , 2006, Antiviral research.
[129] Hemaka A. Rajapakse,et al. A mild and efficient one pot synthesis of 1,3,4-oxadiazoles from carboxylic acids and acyl hydrazides , 2006 .
[130] J. Balsells,et al. Synthesis of 2-amino-5-substituted-1,3,4-oxadiazoles using 1,3-dibromo-5,5-dimethylhydantoin as oxidant , 2006 .
[131] M. Shafique,et al. Synthesis, Antimicrobial and Anti‐HIV Activity of Some Novel Benzenesulfonamides Bearing 2,5‐Disubstituted‐1,3,4‐Oxadiazole Moiety , 2006 .
[132] J. Palmer,et al. Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors. , 2006, Journal of medicinal chemistry.
[133] A. Malikzay,et al. Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines. , 2006, Bioorganic & medicinal chemistry letters.
[134] M. Shi,et al. Halogen effects in Robinson–Gabriel type reaction of cyclopropanecarboxylic acid N′-substituted-hydrazides with PPh3/CX4 , 2005 .
[135] Mahmud Tareq Hassan Khan,et al. Structure-activity relationships of tyrosinase inhibitory combinatorial library of 2,5-disubstituted-1,3,4-oxadiazole analogues. , 2005, Bioorganic & medicinal chemistry.
[136] A. Malin,et al. ORGANIC SYNTHESIS AND INDUSTRIAL ORGANIC CHEMISTRY Synthesis of 2-Chloromethyl-5-aryl-, 2-Chloromethyl- 5-(5-methyl-2-furyl)-, and 2-Chloromethyl-5-(1,5-dimethyl- 2-pyrrolyl)-1,3,4-oxadiazoles from Tetrazole Derivatives , 2005 .
[137] A. Zarghi,et al. Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles. , 2005, Bioorganic & medicinal chemistry letters.
[138] N. Oikonomakos,et al. Kinetic and crystallographic studies on 2‐(β‐D‐glucopyranosyl)‐5‐methyl‐1, 3, 4‐oxadiazole, ‐benzothiazole, and ‐benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site , 2005, Protein science : a publication of the Protein Society.
[139] D. Boger,et al. Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity. , 2005, Bioorganic & medicinal chemistry letters.
[140] A. Çetin,et al. 5-Furan-2yl[1,3,4]oxadiazole-2-thiol, 5-Furan-2yl-4H [1,2,4] triazole-3-thiol and Their Thiol-Thione Tautomerism , 2005, Molecules.
[141] A. Shafiee,et al. Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles. , 2004, Bioorganic & medicinal chemistry letters.
[142] David A. Lustig,et al. CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability. , 2004, Bioorganic & medicinal chemistry letters.
[143] A. Shafiee,et al. Radiosynthesis of [18F]-5-[2-(2-chlorophenoxy)phenyl]-1,3,4-oxadiazole-2-yl-4-fluorobenzoate: A labeled ligand for benzodiazepine receptors , 2004 .
[144] Romualdas Smicius,et al. Synthesis and anti-inflammatory activity of derivatives of 5-[(2-disubstitutedamino-6-methyl-pyrimidin-4-yl)-sulfanylmethyl]-3H-1,3,4-oxadiazole-2-thiones. , 2004, Farmaco.
[145] J. Lehmann,et al. Synthesis, antimicrobial, and anti-HIV-1 activity of certain 5-(1-adamantyl)-2-substituted thio-1,3,4-oxadiazoles and 5-(1-adamantyl)-3-substituted aminomethyl-1,3,4-oxadiazoline-2-thiones. , 2004, Bioorganic & medicinal chemistry.
[146] W. Schleif,et al. P1' oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1. , 2004, Bioorganic & medicinal chemistry letters.
[147] K. Shikha,et al. Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives. , 2004, European journal of medicinal chemistry.
[148] B. G. Rao,et al. Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization. , 2004, Bioorganic & medicinal chemistry letters.
[149] Martin Poirier,et al. Structure-activity study on a novel series of macrocyclic inhibitors of the hepatitis C virus NS3 protease leading to the discovery of BILN 2061. , 2004, Journal of medicinal chemistry.
[150] G. Sharma,et al. Zirconium(IV) Chloride Mediated Cyclodehydration of 1,2‐Diacylhydrazines: A Convenient Synthesis of 2,5‐Diaryl 1,3,4‐Oxadiazoles , 2004 .
[151] Paul Bamborough,et al. Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease. , 2003, Organic letters.
[152] Z. Bian,et al. High-performance blue electroluminescent devices based on 2-(4-biphenylyl)-5-(4-carbazole-9-yl)phenyl-1,3,4-oxadiazole. , 2003, Chemical communications.
[153] Yanli Wang,et al. Syntheses and insecticidal activities of novel 2,5-disubstituted 1,3,4-oxadiazoles , 2003 .
[154] S. Mashraqui,et al. An Expeditious and Convenient One Pot Synthesis of 2,5-Disubstituted-1,3,4-oxadiazoles , 2003 .
[155] Zhisheng Jiang,et al. Synthesis and antifeedant activity of new oxadiazolyl 3(2H)-pyridazinones. , 2003, Journal of agricultural and food chemistry.
[156] M. Goldman,et al. Structure–Activity Relationship Studies of Ethyl 2-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: An Inhibitor of AP-1 and NF-κB Mediated Gene Expression , 2002 .
[157] N. Thornberry,et al. Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. , 2002, Bioorganic & medicinal chemistry letters.
[158] A. Katritzky,et al. Syntheses of 5-(2-arylazenyl)-1,2,4-triazoles and 2-amino-5-aryl-1,3,4-oxadiazoles , 2002 .
[159] M. Ozalp,et al. Synthesis and antimicrobial activity of some 1,3,4-oxadiazole derivatives. , 2002, Farmaco.
[160] A. Maslat,et al. Synthesis, antibacterial, antifungal and genotoxic activity of bis-1,3,4-oxadiazole derivatives. , 2002, Polish journal of pharmacology.
[161] Guangxing Yang,et al. Syntheses and biological activities of novel diheterocyclic compounds containing 1,2,4‐triazolo[1,5‐a]pyrimidine and 1,3,4‐oxadiazole , 2001 .
[162] L. W. Spruce,et al. Development of orally active nonpeptidic inhibitors of human neutrophil elastase. , 2001, Journal of medicinal chemistry.
[163] L. W. Spruce,et al. Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase. , 2000, Journal of medicinal chemistry.
[164] Rong Zhang,et al. Syntheses and insecticidal activities of novel 2-fluorophenyl-5-aryl/cyclopropyl-1,3,4-oxadiazoles , 2000 .
[165] Y. Matsumoto,et al. Studies on anti-Helicobacter pylori agents. Part 2: new cephem derivatives. , 2000, Bioorganic & medicinal chemistry.
[166] Mark E. Thompson,et al. Statistical Copolymers with Side-Chain Hole and Electron Transport Groups for Single-Layer Electroluminescent Device Applications , 2000 .
[167] H. Wikström,et al. New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides. , 2000, Journal of medicinal chemistry.
[168] C. J. Blankley,et al. Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents. , 1996, Journal of medicinal chemistry.