Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate

[1]  J. Valette,et al.  Brain intracellular metabolites are freely diffusing along cell fibers in grey and white matter, as measured by diffusion-weighted MR spectroscopy in the human brain at 7 T , 2016, Brain Structure and Function.

[2]  Istvan Pirko,et al.  Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque , 2015, Annals of neurology.

[3]  D. Reich,et al.  Reproducibility and optimization of in  vivo human diffusion‐weighted MRS of the corpus callosum at 3T and 7T , 2015, NMR in biomedicine.

[4]  A. Cherubini,et al.  The relationship between regional microstructural abnormalities of the corpus callosum and physical and cognitive disability in relapsing–remitting multiple sclerosis , 2014, NeuroImage: Clinical.

[5]  H. Lassmann.  Mechanisms of white matter damage in multiple sclerosis , 2014, Glia.

[6]  Daniel S. Reich,et al.  Sub-millimeter imaging of brain-free water for rapid volume assessment in atrophic brains , 2014, NeuroImage.

[7]  M. Budde,et al.  Microstructural organization of axons in the human corpus callosum quantified by diffusion-weighted magnetic resonance spectroscopy of N-acetylaspartate and post-mortem histology , 2014, Brain Structure and Function.

[8]  I. Ronen,et al.  Rapid multi‐echo measurement of brain metabolite T2 values at 7 T using a single‐shot spectroscopic Carr–Purcell–Meiboom–Gill sequence and prior information , 2013, NMR in biomedicine.

[9]  C. Crainiceanu,et al.  Quantification of multiple-sclerosis-related brain atrophy in two heterogeneous MRI datasets using mixed-effects modeling☆ , 2013, NeuroImage: Clinical.

[10]  M. Battaglini,et al.  Brain metabolic changes suggestive of axonal damage in radiologically isolated syndrome , 2013, Neurology.

[11]  Itamar Ronen,et al.  Axonal and glial microstructural information obtained with diffusion-weighted magnetic resonance spectroscopy at 7T , 2013, Front. Integr. Neurosci..

[12]  Assaf Tal,et al.  Serial proton MR spectroscopy of gray and white matter in relapsing-remitting MS , 2013, Neurology.

[13]  M. Dwyer,et al.  Subcortical and Cortical Gray Matter Atrophy in a Large Sample of Patients with Clinically Isolated Syndrome and Early Relapsing-Remitting Multiple Sclerosis , 2012, American Journal of Neuroradiology.

[14]  Philippe Hantraye,et al.  Anomalous Diffusion of Brain Metabolites Evidenced by Diffusion-Weighted Magnetic Resonance Spectroscopy in Vivo , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[15]  M. Czisch,et al.  Brain Volume and Diffusion Markers as Predictors of Disability and Short-Term Disease Evolution in Multiple Sclerosis , 2012, American Journal of Neuroradiology.

[16]  Khader M Hasan,et al.  Multi‐modal quantitative MRI investigation of brain tissue neurodegeneration in multiple sclerosis , 2012, Journal of magnetic resonance imaging : JMRI.

[17]  Peter A. Calabresi,et al.  Revisiting Brain Atrophy and Its Relationship to Disability in Multiple Sclerosis , 2012, PloS one.

[18]  Peter B Barker,et al.  Investigating Axonal Damage in Multiple Sclerosis by Diffusion Tensor Spectroscopy , 2012, The Journal of Neuroscience.

[19]  Itamar Ronen,et al.  Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T , 2012, Magnetic resonance in medicine.

[20]  D. Mahad,et al.  Mitochondrial changes associated with demyelination: consequences for axonal integrity. , 2012, Mitochondrion.

[21]  Indika S. Walimuni,et al.  Human brain atlas-based multimodal MRI analysis of volumetry, diffusimetry, relaxometry and lesion distribution in multiple sclerosis patients and healthy adult controls: Implications for understanding the pathogenesis of multiple sclerosis and consolidation of quantitative MRI results in MS , 2012, Journal of the Neurological Sciences.

[22]  K. Schmierer,et al.  Axonal damage in the making: Neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter☆ , 2011, Experimental Neurology.

[23]  W. Brück,et al.  Axonal Loss and Neurofilament Phosphorylation Changes Accompany Lesion Development and Clinical Progression in Multiple Sclerosis , 2011, Brain pathology.

[24]  Aaron Carass,et al.  Simple paradigm for extra-cerebral tissue removal: Algorithm and analysis , 2011, NeuroImage.

[25]  Achim Gass,et al.  Fatigue and progression of corpus callosum atrophy in multiple sclerosis , 2011, Journal of Neurology.

[26]  Jeffrey A. Cohen,et al.  Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria , 2011, Annals of neurology.

[27]  Jan Klein,et al.  Comparison of Diffusion Tensor‐Based Tractography and Quantified Brain Atrophy for Analyzing Demyelination and Axonal Loss in MS , 2010, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[28]  Mingqiang Xie,et al.  Rostrocaudal Analysis of Corpus Callosum Demyelination and Axon Damage Across Disease Stages Refines Diffusion Tensor Imaging Correlations With Pathological Features , 2010, Journal of neuropathology and experimental neurology.

[29]  M. Battaglini,et al.  Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes , 2010, Neurology.

[30]  Bennett A Landman,et al.  q‐space and conventional diffusion imaging of axon and myelin damage in the rat spinal cord after axotomy , 2010, Magnetic resonance in medicine.

[31]  Ludwig Kappos,et al.  A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. , 2010, The New England journal of medicine.

[32]  Peter A. Calabresi,et al.  Automated vs. conventional tractography in multiple sclerosis: Variability and correlation with disability , 2010, NeuroImage.

[33]  P. Calabresi,et al.  MRI of the corpus callosum in multiple sclerosis: association with disability , 2010, Multiple sclerosis.

[34]  Peter A. Calabresi,et al.  A topology-preserving approach to the segmentation of brain images with multiple sclerosis lesions , 2010, NeuroImage.

[35]  Jerry L Prince,et al.  The Java Image Science Toolkit (JIST) for Rapid Prototyping and Publishing of Neuroimaging Software , 2010, Neuroinformatics.

[36]  Nicola De Stefano,et al.  Gray matter atrophy correlates with MS disability progression measured with MSFC but not EDSS , 2009, Journal of the Neurological Sciences.

[37]  Bennett A Landman,et al.  Complex geometric models of diffusion and relaxation in healthy and damaged white matter , 2009, NMR in biomedicine.

[38]  H. Rusinek,et al.  MR spectroscopy indicates diffuse multiple sclerosis activity during remission , 2009, Journal of Neurology, Neurosurgery & Psychiatry.

[39]  Hans Lassmann,et al.  The relation between inflammation and neurodegeneration in multiple sclerosis brains , 2009, Brain : a journal of neurology.

[40]  Susumu Mori,et al.  Diffusion Tensor Magnetic Resonance Imaging of Wallerian Degeneration in Rat Spinal Cord after Dorsal Root Axotomy , 2009, The Journal of Neuroscience.

[41]  Sheng-Kwei Song,et al.  Axial Diffusivity Is the Primary Correlate of Axonal Injury in the Experimental Autoimmune Encephalomyelitis Spinal Cord: A Quantitative Pixelwise Analysis , 2009, The Journal of Neuroscience.

[42]  Frederik Barkhof,et al.  Regional DTI differences in multiple sclerosis patients , 2009, NeuroImage.

[43]  K. Schmierer,et al.  Phosphorylation and compactness of neurofilaments in multiple sclerosis: Indicators of axonal pathology , 2008, Experimental Neurology.

[44]  Pierre-Louis Bazin,et al.  Homeomorphic brain image segmentation with topological and statistical atlases , 2008, Medical Image Anal..

[45]  R. Rudick,et al.  Gray matter atrophy in multiple sclerosis: A longitudinal study , 2008, Annals of neurology.

[46]  P. Narayana,et al.  Longitudinal magnetic resonance spectroscopic imaging of primary progressive multiple sclerosis patients treated with glatiramer acetate: multicenter study , 2008, Multiple sclerosis.

[47]  Itamar Ronen,et al.  Diffusion properties of NAA in human corpus callosum as studied with diffusion tensor spectroscopy , 2007, Magnetic resonance in medicine.

[48]  H. Schild,et al.  Axonal Damage But No Increased Glial Cell Activity in the Normal-Appearing White Matter of Patients with Clinically Isolated Syndromes Suggestive of Multiple Sclerosis Using High-Field Magnetic Resonance Spectroscopy , 2007, American Journal of Neuroradiology.

[49]  Susumu Mori,et al.  High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord. , 2007, Brain : a journal of neurology.

[50]  O. Ciccarelli,et al.  Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis. , 2007, Brain : a journal of neurology.

[51]  C. Pozzilli,et al.  Effect of corpus callosum damage on ipsilateral motor activation in patients with multiple sclerosis: A functional and anatomical study , 2007, Human brain mapping.

[52]  Joong Hee Kim,et al.  Diffusion tensor imaging predicts hyperacute spinal cord injury severity. , 2007, Journal of neurotrauma.

[53]  Ji-Kyung Choi,et al.  Application of MRS to mouse models of neurodegenerative illness , 2007, NMR in biomedicine.

[54]  Luis Concha,et al.  Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients , 2006, NeuroImage.

[55]  Rohit Bakshi,et al.  The measurement and clinical relevance of brain atrophy in multiple sclerosis , 2006, The Lancet Neurology.

[56]  Hsiao-Fang Liang,et al.  Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum , 2006, Magnetic resonance in medicine.

[57]  A. Thompson,et al.  Metabolite changes in early relapsing–remitting multiple sclerosis , 2006, Journal of Neurology.

[58]  M. Rovaris,et al.  Axonal injury and overall tissue loss are not related in primary progressive multiple sclerosis. , 2005, Archives of neurology.

[59]  Daniel Pelletier,et al.  Corpus callosum axonal injury in multiple sclerosis measured by proton magnetic resonance spectroscopic imaging. , 2004, Archives of neurology.

[60]  Sajja B Rao,et al.  Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis , 2004, Multiple sclerosis.

[61]  R. Grossman,et al.  Neuronal cell injury precedes brain atrophy in multiple sclerosis , 2004, Neurology.

[62]  S. Nelson,et al.  MRI lesion volume heterogeneity in primary progressive MS in relation with axonal damage and brain atrophy , 2003, Journal of neurology, neurosurgery, and psychiatry.

[63]  Oded Gonen,et al.  Diffusely elevated cerebral choline and creatine in relapsing‐remitting multiple sclerosis , 2003, Magnetic resonance in medicine.

[64]  F. Aboitiz,et al.  One hundred million years of interhemispheric communication: the history of the corpus callosum. , 2003, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[65]  M Rovaris,et al.  Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. , 2003, Brain : a journal of neurology.

[66]  Stephen M. Smith,et al.  Accurate, Robust, and Automated Longitudinal and Cross-Sectional Brain Change Analysis , 2002, NeuroImage.

[67]  Stephen M. Smith,et al.  A global optimisation method for robust affine registration of brain images , 2001, Medical Image Anal..

[68]  Matthew J. McAuliffe,et al.  Medical Image Processing, Analysis and Visualization in clinical research , 2001, Proceedings 14th IEEE Symposium on Computer-Based Medical Systems. CBMS 2001.

[69]  R Stollberger,et al.  Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis , 2000, Magnetic resonance in medicine.

[70]  M W Weiner,et al.  1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS , 2000, Multiple sclerosis.

[71]  Nikos Evangelou,et al.  Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis , 2000, Annals of neurology.

[72]  Geoff J. M. Parker,et al.  1H Magnetic resonance spectroscopy of normal appearing white matter in primary progressive multiple sclerosis , 1999, Journal of Neurology.

[73]  G. Barker,et al.  Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis , 1999, Neurology.

[74]  M. Banich.  The Missing Link: The Role of Interhemispheric Interaction in Attentional Processing , 1998, Brain and Cognition.

[75]  Alan C. Evans,et al.  A nonparametric method for automatic correction of intensity nonuniformity in MRI data , 1998, IEEE Transactions on Medical Imaging.

[76]  R. Rudick,et al.  Axonal transection in the lesions of multiple sclerosis. , 1998, The New England journal of medicine.

[77]  G. Barker,et al.  1H magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis , 1997, Journal of neurology, neurosurgery, and psychiatry.

[78]  S. Provencher.  Estimation of metabolite concentrations from localized in vivo proton NMR spectra , 1993, Magnetic resonance in medicine.

[79]  R. Sergott.  Diffusion Tensor Imaging in Acute Optic Neuropathies: Predictor of Clinical Outcomes , 2012 .

[80]  H Ohki,et al.  [Wallerian degeneration]. , 1993, Nihon rinsho. Japanese journal of clinical medicine.