Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

[1]  Wei Wang,et al.  Sestrins inhibit mTORC1 kinase activation through the GATOR complex. , 2014, Cell reports.

[2]  Steven P Gygi,et al.  The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. , 2014, Cell reports.

[3]  Ming O. Li,et al.  Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling , 2014, Cell.

[4]  Myungjin Kim,et al.  Sestrin2 promotes Unc‐51‐like kinase 1 mediated phosphorylation of p62/sequestosome‐1 , 2014, The FEBS journal.

[5]  D. Sabatini,et al.  Regulation of mTORC1 by amino acids. , 2014, Trends in cell biology.

[6]  Myungjin Kim,et al.  Hepatoprotective role of Sestrin2 against chronic ER stress , 2014, Nature Communications.

[7]  Y. Wei,et al.  The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila , 2014, Cell Death and Differentiation.

[8]  Dudley Lamming,et al.  RagA, but not RagB, is essential for embryonic development and adult mice. , 2014, Developmental cell.

[9]  M. Karin,et al.  Sestrins orchestrate cellular metabolism to attenuate aging. , 2013, Cell metabolism.

[10]  K. Friese,et al.  Nelfinavir and bortezomib inhibit mTOR activity via ATF4‐mediated sestrin‐2 regulation , 2013, Molecular oncology.

[11]  D. Bernlohr,et al.  Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes , 2013, Autophagy.

[12]  D. Sabatini,et al.  The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. , 2013, Molecular cell.

[13]  C. De Virgilio,et al.  SEACing the GAP that nEGOCiates TORC1 activation , 2013, Cell cycle.

[14]  C. De Virgilio,et al.  Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1 , 2013, Science Signaling.

[15]  I. Ben-Sahra,et al.  Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death , 2012, Cell Death and Differentiation.

[16]  Matthew Meyerson,et al.  A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1 , 2013, Science.

[17]  Hye Eun Lee,et al.  Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. , 2013, Cell metabolism.

[18]  C. D. Virgilio,et al.  Evolutionary conservation of Rag GTPase regulation , 2013 .

[19]  D. Sabatini,et al.  Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1 , 2012, Cell.

[20]  Mark Ellisman,et al.  Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. , 2012, Cell metabolism.

[21]  D. Hardie,et al.  AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.

[22]  T. Tsakiridis,et al.  Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells , 2012, PloS one.

[23]  D. Sabatini,et al.  mTOR: from growth signal integration to cancer, diabetes and ageing , 2010, Nature Reviews Molecular Cell Biology.

[24]  K. Guan,et al.  Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. , 2011, Genes & development.

[25]  M. Karin,et al.  Stressin' Sestrins take an aging fight , 2010, EMBO molecular medicine.

[26]  D. Sabatini,et al.  Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids , 2010, Cell.

[27]  Mark H. Ellisman,et al.  Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies , 2010, Science.

[28]  Ronald W. Davis,et al.  A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex , 2009, PLoS genetics.

[29]  Michael Karin,et al.  p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling , 2009, Cell.

[30]  T. P. Neufeld,et al.  Regulation of TORC1 by Rag GTPases in nutrient response , 2008, Nature Cell Biology.

[31]  David M. Sabatini,et al.  The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 , 2008, Science.

[32]  B. Turk,et al.  AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.

[33]  B. Viollet,et al.  5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments , 2006, Molecular and Cellular Biology.

[34]  A. F. Castro,et al.  Measuring Ras-family GTP levels in vivo--running hot and cold. , 2005, Methods.

[35]  N. Sonenberg,et al.  Upstream and downstream of mTOR. , 2004, Genes & development.

[36]  K. Inoki,et al.  TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.

[37]  C. Horbinski,et al.  Polyethyleneimine-mediated transfection of cultured postmitotic neurons from rat sympathetic ganglia and adult human retina , 2001, BMC Neuroscience.

[38]  A. Schürmann,et al.  Cloning of a Novel Family of Mammalian GTP-binding Proteins (RagA, RagBs, RagB1) with Remote Similarity to the Ras-related GTPases * , 1995, The Journal of Biological Chemistry.