This chapter explores various ways to detect and ultimately remove spyware from infected computers. The Microsoft Windows operating system is easily the most popular operating system in use today, and it provides very efficient and streamlined access to data and applications. It is not only powerful enough to run mission-critical networks but also user-friendly enough for home computer users. Striking a fine balance in terms of performance, convenience, and security is hard to accomplish, and, unfortunately, sometimes in modern Windows operating systems security takes a back seat to convenience and performance. In situations like these, gaps within the operating systems security model allow malicious applications and spyware to gain a foothold in the system and ultimately infect the entire computer. Some of the popular tools for uncovering spyware automatically and removing them include HijackThis and a-squared HijackFree.