Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia.

[1]  J. Licht,et al.  Transcription factors, normal myeloid development, and leukemia. , 1997, Blood.

[2]  I. Weissman,et al.  Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice , 1997, Cell.

[3]  J. D. Vos,et al.  Fas/Apo-1(CD95) expression and apoptosis in patients with myelodysplastic syndromes , 1997, Leukemia.

[4]  H. Drexler,et al.  Expression and function of CD95 (FAS/APO‐1) in leukaemia‐lymphoma tumour lines , 1997, British journal of haematology.

[5]  M. Marín‐Padilla,et al.  Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene , 1997, Nature Genetics.

[6]  S. Nagata,et al.  Apoptosis by Death Factor , 1997, Cell.

[7]  J. Zhang,et al.  The AML1/ETO fusion protein activates transcription of BCL-2. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[8]  A. Hayday,et al.  A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice , 1996, The Journal of experimental medicine.

[9]  P. Kiener,et al.  Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils , 1996, The Journal of experimental medicine.

[10]  S. Korsmeyer,et al.  Molecular thanatopsis: a discourse on the BCL2 family and cell death. , 1996, Blood.

[11]  Seok Lee,et al.  Expression of Fas antigen in acute myeloid leukaemia is associated with therapeutic response to chemotherapy , 1996, British Journal of Haematology.

[12]  K. Akashi,et al.  Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia. , 1996, Blood.

[13]  M. Marín‐Padilla,et al.  Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[14]  I. Weissman,et al.  Hematopoietic stem cells are not direct cytotoxic targets of natural killer cells. , 1996, Blood.

[15]  J. Downing,et al.  AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis , 1996, Cell.

[16]  A. Strasser,et al.  Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis. , 1995, The EMBO journal.

[17]  Y. Komada,et al.  Fas receptor (CD95)-mediated apoptosis is induced in leukemic cells entering G1B compartment of the cell cycle. , 1995, Blood.

[18]  C. Smith,et al.  Fas ligand mediates activation-induced cell death in human T lymphocytes , 1995, The Journal of experimental medicine.

[19]  T. Rabbitts,et al.  Chromosomal translocations in human cancer , 1994, Nature.

[20]  I. Weissman,et al.  The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. , 1994, Immunity.

[21]  A. Strasser,et al.  Insights from transgenic mice regarding the role of bcl-2 in normal and neoplastic lymphoid cells. , 1994, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[22]  J. Tschopp,et al.  Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways , 1994, Nature.

[23]  A. Abbas,et al.  The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. , 1994, Immunity.

[24]  H Hengartner,et al.  Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. , 1994, Science.

[25]  P. Krammer,et al.  Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells. , 1994, Journal of immunology.

[26]  S. Nagata,et al.  Purification and characterization of the Fas-ligand that induces apoptosis , 1994, The Journal of experimental medicine.

[27]  I. Weissman,et al.  bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages , 1994, The Journal of experimental medicine.

[28]  I. Weissman,et al.  Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells , 1993, The Journal of cell biology.

[29]  J. Rowley,et al.  Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission. , 1993, Blood.

[30]  S. Nagata,et al.  Effect of bcl-2 on Fas antigen-mediated cell death. , 1993, Journal of immunology.

[31]  C. Weaver,et al.  Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[32]  H. Drabkin,et al.  Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. , 1992, Blood.

[33]  M. Pierotti,et al.  bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells. , 1992, Blood.

[34]  M. Ohki,et al.  t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[35]  R. Weinberg,et al.  Tumor suppressor genes. , 1991, Science.

[36]  T. Rabbitts.  Translocations, master genes, and differences between the origins of acute and chronic leukemias , 1991, Cell.

[37]  K. Akashi,et al.  Effects of interleukin-4 and interleukin-6 on the proliferation of CD34+ and CD34- blasts from acute myelogenous leukemia. , 1991, Blood.

[38]  C. Marshall.  Tumor suppressor genes , 1991, Cell.

[39]  Christopher T Denny,et al.  Leukemia and the disruption of normal hematopoiesis , 1991, Cell.

[40]  D. Metcalf,et al.  The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells , 1989, Nature.

[41]  David L. Vaux,et al.  Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells , 1988, Nature.

[42]  I. Weissman,et al.  Purification and characterization of mouse hematopoietic stem cells. , 1988, Science.

[43]  S. Collins,et al.  The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. , 1987, Blood.

[44]  J. Sklar,et al.  Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[45]  S. Korsmeyer,et al.  Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18 , 1985, Cell.

[46]  H. Gralnick,et al.  Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative Group , 1976, British journal of haematology.

[47]  J. Till,et al.  A cytological study of the capacity for differentiation of normal hemopoietic colony‐forming cells , 1967, Journal of cellular physiology.

[48]  J. Till,et al.  Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells , 1963, Nature.

[49]  J. Till,et al.  A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. , 1961, Radiation research.

[50]  J. Ritz,et al.  Functional consequences of APO-1/Fas (CD95) antigen expression by normal and neoplastic hematopoietic cells. , 1995, Leukemia & lymphoma.

[51]  S. Sacchi,et al.  Bcl-2 oncoprotein expression in acute myeloid leukemia. , 1995, Haematologica.