Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress

[1]  Rahul Wadke,et al.  Atrial fibrillation. , 2022, Disease-a-month : DM.

[2]  Paulo Pereira,et al.  Autophagy and ubiquitination in cardiovascular diseases. , 2015, DNA and cell biology.

[3]  R. Wijesurendra,et al.  Atrial fibrillation: effects beyond the atrium? , 2015, Cardiovascular research.

[4]  Jianhua Zhang.  Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches , 2015, Redox biology.

[5]  X. Li,et al.  Autophagy collaborates with ubiquitination to downregulate oncoprotein E2A/Pbx1 in B-cell acute lymphoblastic leukemia , 2014, Blood Cancer Journal.

[6]  Christopher J. Davidson,et al.  Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells. , 2014, Free radical biology & medicine.

[7]  D. Cyr,et al.  Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR. , 2014, Molecular cell.

[8]  Xiang Xue,et al.  4-Hydroxy-2-nonenal Induces Apoptosis by Inhibiting AKT Signaling in Human Osteosarcoma Cells , 2014, TheScientificWorldJournal.

[9]  R. Brandes,et al.  Targeting inflammation and oxidative stress in atrial fibrillation: role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins. , 2014, Antioxidants & redox signaling.

[10]  N. Marrouche,et al.  Abstract 284: Disruption of Nrf2 Promotes Atrial Remodeling and Fibrillation on Aging , 2013 .

[11]  J. Harper,et al.  Uba1 functions in Atg7- and Atg3-independent autophagy , 2013, Nature Cell Biology.

[12]  J. Mehta,et al.  ALDH2 protects against stroke by clearing 4-HNE , 2013, Cell Research.

[13]  C. Miracco,et al.  microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells , 2013, Cancer biology & therapy.

[14]  M. Pagano,et al.  Role of the Ubiquitin Proteasome System in the Heart , 2013, Circulation research.

[15]  J. Zierath,et al.  Exercise metabolism and the molecular regulation of skeletal muscle adaptation. , 2013, Cell metabolism.

[16]  Jianhua Zhang.  Autophagy and mitophagy in cellular damage control☆ , 2013, Redox biology.

[17]  J. Obata,et al.  Chronic depletion of glutathione exacerbates ventricular remodelling and dysfunction in the pressure-overloaded heart. , 2013, Cardiovascular research.

[18]  H. Halperin,et al.  Atrial fibrillation and diffuse left ventricular fibrosis, a causal association? , 2012, Journal of the American College of Cardiology.

[19]  G. Barrera.  Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy , 2012, ISRN oncology.

[20]  S. Odelberg,et al.  Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training , 2012, PloS one.

[21]  R. Paine,et al.  Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle. , 2012, Biochimica et biophysica acta.

[22]  E. Anderson,et al.  Frontiers in Research: Obesity and Health Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart , 2012 .

[23]  Christopher J. Davidson,et al.  Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium. , 2012, Free radical biology & medicine.

[24]  N. Frangogiannis,et al.  Regulation of the inflammatory response in cardiac repair. , 2012, Circulation research.

[25]  Stanley Nattel,et al.  Atrial fibrillation pathophysiology: implications for management. , 2011, Circulation.

[26]  Yahui Kong,et al.  Oxidative Stress, Mitochondrial Dysfunction, and Aging , 2011, Journal of signal transduction.

[27]  D. Rubinsztein,et al.  Autophagy and Aging , 2011, Cell.

[28]  A. Koeppen,et al.  Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. , 2011, Brain : a journal of neurology.

[29]  Min Zhang,et al.  Redox signaling in cardiac myocytes , 2011, Free radical biology & medicine.

[30]  Christopher J. Davidson,et al.  Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice. , 2011, Antioxidants & redox signaling.

[31]  Nektarios Tavernarakis,et al.  The role of autophagy in genetic pathways influencing ageing , 2011, Biogerontology.

[32]  Guido Kroemer,et al.  Autophagy and the integrated stress response. , 2010, Molecular cell.

[33]  D. Rubinsztein,et al.  Regulation of mammalian autophagy in physiology and pathophysiology. , 2010, Physiological reviews.

[34]  Nektarios Tavernarakis,et al.  Can autophagy promote longevity? , 2010, Nature Cell Biology.

[35]  T. Yao.  The role of ubiquitin in autophagy-dependent protein aggregate processing. , 2010, Genes & cancer.

[36]  M. Frenneaux,et al.  Increased atrial contribution to left ventricular filling compensates for impaired early filling during exercise in heart failure with preserved ejection fraction. , 2009, Journal of cardiac failure.

[37]  D. Lawrence,et al.  Reduced glutathione is highly expressed in white matter and neurons in the unperturbed mouse brain — Implications for oxidative stress associated with neurodegeneration , 2009, Brain Research.

[38]  Masayuki Yamamoto,et al.  Disruption of Nrf2 Impairs the Resolution of Hyperoxia-Induced Acute Lung Injury and Inflammation in Mice1 , 2009, The Journal of Immunology.

[39]  Silke Meiners,et al.  Comprehensive proteomic and transcriptomic analysis reveals early induction of a protective anti‐oxidative stress response by low‐dose proteasome inhibition , 2009, Proteomics.

[40]  K. Davies,et al.  Exercise improves import of 8-oxoguanine DNA glycosylase into the mitochondrial matrix of skeletal muscle and enhances the relative activity. , 2009, Free radical biology & medicine.

[41]  M. Willis,et al.  The ubiquitin-proteasome system in cardiac dysfunction. , 2008, Biochimica et biophysica acta.

[42]  R. Weiss,et al.  Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice. , 2008, Physiological genomics.

[43]  Peng Huang,et al.  Redox regulation of cell survival. , 2008, Antioxidants & redox signaling.

[44]  T. Kensler,et al.  Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. , 2008, Mutation research.

[45]  Alexandru B. Chicos,et al.  Atrial and ventricular fibrosis induced by atrial fibrillation: evidence to support early rhythm control. , 2008, Heart rhythm.

[46]  K. Davies,et al.  Production, detection, and adaptive responses to free radicals in exercise. , 2008, Free radical biology & medicine.

[47]  K. Davies,et al.  Free radicals and exercise: an introduction. , 2008, Free radical biology & medicine.

[48]  J. Goudevenos,et al.  The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation. , 2007, International journal of cardiology.

[49]  C. Willey,et al.  Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases. , 2006, Journal of molecular and cellular cardiology.

[50]  S. Pepe,et al.  Energy deficiency in the failing heart: linking increased reactive oxygen species and disruption of oxidative phosphorylation rate. , 2006, Biochimica et biophysica acta.

[51]  W. Mitzner,et al.  Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice , 2005, The Journal of experimental medicine.

[52]  Irina Petrache,et al.  Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. , 2004, The Journal of clinical investigation.

[53]  J. Sepulveda,et al.  Gene expression changes associated with fibronectin-induced cardiac myocyte hypertrophy. , 2004, Physiological genomics.

[54]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[55]  H. Masutani,et al.  Hemin-induced Activation of the Thioredoxin Gene by Nrf2 , 2001, The Journal of Biological Chemistry.

[56]  D. Singer,et al.  Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. , 2001, JAMA.

[57]  E. Rubin,et al.  Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[58]  R. Arcilla,et al.  Dexamethasone induced cardiac hypertrophy in newborn rats is accompanied by changes in myosin heavy chain phenotype and gene transcription , 2000, Molecular and Cellular Biochemistry.

[59]  C. B. Pickett,et al.  Transcriptional Regulation of the Antioxidant Response Element , 2000, The Journal of Biological Chemistry.

[60]  李永军,et al.  Atrial Fibrillation , 1999 .

[61]  I. Fridovich,et al.  Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. , 1998, Free radical biology & medicine.

[62]  R. Matsuoka,et al.  Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. , 1987, The Journal of clinical investigation.

[63]  Simon C Watkins,et al.  Hereditary pituitary dwarfism in mice affects skeletal and cardiac myosin isozyme transitions differently , 1985, The Journal of cell biology.

[64]  Y. Yazaki,et al.  Isozymic changes in myosin of human atrial myocardium induced by overload. Immunohistochemical study using monoclonal antibodies. , 1984, The Journal of clinical investigation.

[65]  E. Morkin,et al.  Myosin isoenzyme expression in rat ventricle: effects of thyroid hormone analogs, catecholamines, glucocorticoids and high carbohydrate diet. , 1984, The Journal of pharmacology and experimental therapeutics.

[66]  S. Schiaffino,et al.  Myosin Types in the Human Heart: An Immunofluorescence Study of Normal and Hypertrophied Atrial and Ventricular Myocardium , 1984, Circulation research.

[67]  J. Scheuer,et al.  The Effects of Gonadectomy on Left Ventricular Function and Cardiac Contractile Proteins in Male and Female Rats , 1984, Circulation research.

[68]  E. Sonnenblick,et al.  The Effect of Streptozotocin‐Induced Diabetes in Rats on Cardiac Contractile Proteins , 1981, Circulation research.

[69]  W. Dillmann.  Diabetes Mellitus Induces Changes in Cardiac Myosin of the Rat , 1980, Diabetes.

[70]  Mark E. Anderson,et al.  Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013. , 2015, Heart rhythm.

[71]  Edward G Lakatta,et al.  Aging-associated cardiovascular changes and their relationship to heart failure. , 2012, Heart failure clinics.

[72]  K. Pandey,et al.  Markers of oxidative stress in erythrocytes and plasma during aging in humans , 2010, Oxidative medicine and cellular longevity.

[73]  K. A. Lindl,et al.  Examining the endogenous antioxidant response through immunofluorescent analysis of Nrf2 in tissue. , 2008, Methods in molecular biology.

[74]  T. Ueno,et al.  LC3 and Autophagy. , 2008, Methods in molecular biology.

[75]  Mazhar Adli,et al.  Resveratrol protects against 4‐HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts , 2004, BioFactors.