论文信息 - Pattern of Adaptive Control of Levels of Rat Liver Tryptophan Transaminase

Pattern of Adaptive Control of Levels of Rat Liver Tryptophan Transaminase

The dual control by substrate and hormone of the level of a third adaptive enzyme in animals is described. Injections of hydrocortisone or the substrate tryptophan increased the level of the liver tryptophan-α-ketoglutarate transaminase of intact rats within 5 hours. In adrenalectomized rats this enzyme level was increased by hydrocortisone alone, but substrate induction could be demonstrated only if these animals were treated at the same time with hydrocortisone.

M. Civen | W. Knox

[1] E. Lin,et al. Effect of vitamin B6 deficiency on the basal and adapted levels of rat liver tyrosine and tryptophan transaminases. , 1958, The Journal of biological chemistry.

[2] E. Lin,et al. The assay of aromatic amino acid transaminations and keto acid oxidation by the enol borate-tautomerase method. , 1958, The Journal of biological chemistry.

[3] E. Lin,et al. Adaptation of the rat liver tyrosine-α-ketoglutarate transaminase☆ , 1957 .

[4] E. Lin,et al. Enzymatic and metabolic adaptations in animals. , 1956, Physiological reviews.

[5] Knox We. Two Mechanisms which Increase in vivo the Liver Tryptophan Peroxidase Activity: Specific Enzyme Adaptation and Stimulation of the Pituitary-Adrenal System , 1951 .