Room-temperature Pd(ii)-catalyzed direct C–H TIPS-ethynylation of phenylacetic amides with terminal alkynes

Ligand-promoted Pd(ii)-catalyzed direct C–H alkynylation of phenylacetic amides has been developed, where 8-aminoquinoline was employed as a removable bidentate auxiliary, giving rise to optically pure ortho-alkynylated α-APA.

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