The osteoporosis self-assessment screening tool: a useful tool for the orthopaedic surgeon.

BACKGROUND Simple and effective methods are needed to identify patients at risk for osteoporosis or osteoporosis-related fracture so that they can be screened with use of dual x-ray absorptiometry and counseled for treatment. Currently, we use a cumbersome survey assessing thirty-two risk factors. A much simpler score based on the Osteoporosis Self-Assessment Screening Tool (OST score) has been established as highly sensitive and specific in women, but similar data are lacking for men. This score is calculated by subtracting the age of the patient in years from the weight in kilograms and multiplying the result by 0.2. Our goal was to test the hypothesis that the OST score is more sensitive and specific than our extensive risk-assessment survey in men. METHODS Using axial dual x-ray absorptiometry analysis, we evaluated a cohort of men who had either responded to our newspaper advertisement or were seen as patients in our orthopaedic clinic. Patients filled out the risk-assessment survey at the time of scanning. Osteoporosis was defined as a T-score of -2.5 or less in the lumbar spine, hip, or femoral neck. RESULTS Twenty-seven (17%) of 158 white men, with a mean age of 67.5 years and a mean weight of 85.3 kg, had osteoporosis. After analysis of the thirty-two risk factors, two remained as significant independent predictors in the final multivariable model (p = 0.042 and p = 0.015). This model had an area under the receiver operating characteristic curve of 0.68 (>0.70 is considered to provide acceptable discrimination). The OST scores ranged from -6 (greatest risk) to 16 (least risk). With use of the OST score to predict osteoporosis, the area under the receiver operating characteristic curve was 0.76. The cutoff of an OST score of <2 provided the largest area under the receiver operating characteristic curve (0.74), with test characteristics for an OST score of <2 including a sensitivity of 85%, specificity of 64%, positive predictive value of 31%, and negative predictive value of 96%. CONCLUSIONS The Osteoporosis Self-Assessment Screening Tool score is superior to a broad risk-factor analysis in the identification of men at risk for osteoporosis or osteoporotic fractures. We have found it simple to use in our clinic to determine which patients should undergo dual x-ray absorptiometry screening. LEVEL OF EVIDENCE Diagnostic Level I. See Instructions to Authors for a complete description of levels of evidence.

[1]  B. Pal,et al.  The management of osteoporosis-related fractures: a survey of orthopaedic surgeons' practice. , 1998, Clinical and experimental rheumatology.

[2]  J. Lane,et al.  Osteoporosis: a review. , 2004, Clinical orthopaedics and related research.

[3]  J. Skedros The orthopaedic surgeon’s role in diagnosing and treating patients with osteoporotic fractures: standing discharge orders may be the solution for timely medical care , 2004, Osteoporosis International.

[4]  Jacques P. Brown,et al.  Evaluation of decision rules for referring women for bone densitometry by dual-energy x-ray absorptiometry. , 2001, JAMA.

[5]  R. Stine,et al.  Development and validation of a simple questionnaire to facilitate identification of women likely to have low bone density. , 1998, The American journal of managed care.

[6]  S. Cummings,et al.  Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. , 1995, The New England journal of medicine.

[7]  Harry K. Genant,et al.  Interim Report and Recommendations of the World Health Organization Task-Force for Osteoporosis , 1999, Osteoporosis International.

[8]  J. Zuckerman,et al.  Hip fracture epidemiology: a review. , 1999, American journal of orthopedics.

[9]  E. Lewiecki,et al.  Update on bone density testing , 2005, Current osteoporosis reports.

[10]  R. Wasnich Consensus and the T-score fallacy , 1997, Clinical Rheumatology.

[11]  K. Freedman Osteoporosis prevention and the orthopaedic surgeon: when fracture care is not enough. , 1999, The Journal of bone and joint surgery. American volume.

[12]  J. Skedros,et al.  Knowledge and opinions of orthopaedic surgeons concerning medical evaluation and treatment of patients with osteoporotic fracture. , 2006, The Journal of bone and joint surgery. American volume.

[13]  C. Cryer,et al.  Hip Fractures: A Future Epidemic? , 1990, Journal of orthopaedic trauma.

[14]  J. del Pino-Montes,et al.  Prevalence of osteoporosis using DXA bone mineral density measurements at the calcaneus: cut-off points of diagnosis and exclusion of osteoporosis. , 2005, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[15]  J. Kaufman,et al.  Interest of a Prescreening Questionnaire to Reduce the Cost of Bone Densitometry , 2002, Osteoporosis International.

[16]  J. Kanis,et al.  Bone fragility in men - where are we? , 2006, Osteoporosis International.

[17]  S. Schappert Office visits to orthopedic surgeons: United States, 1995-96. , 1998, Advance data.

[18]  G. Haugeberg,et al.  Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Arthritis register. , 2000, Arthritis and rheumatism.

[19]  C. Ambrose,et al.  Undertreatment of osteoporosis in men with hip fracture. , 2002, Archives of internal medicine.

[20]  C C Glüer,et al.  Comparisons of Noninvasive Bone Mineral Measurements in Assessing Age‐Related Loss, Fracture Discrimination, and Diagnostic Classification , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[21]  R. Keller,et al.  Basic Epidemiology of Fractures of the Upper and Lower Limb among Americans over 65 Years of Age , 1996, Epidemiology.

[22]  Susan R. Johnson,et al.  Osteoporosis prevention, diagnosis, and therapy. , 2001, JAMA.

[23]  R. Adler,et al.  Performance of the Osteoporosis Self-assessment Screening Tool for osteoporosis in American men. , 2003, Mayo Clinic proceedings.

[24]  J. Reginster,et al.  Validation and comparative evaluation of the osteoporosis self-assessment tool (OST) in a Caucasian population from Belgium. , 2004, QJM : monthly journal of the Association of Physicians.

[25]  M. Kleerekoper,et al.  Osteoporosis in Men: Diagnosis, Pathophysiology, and Prevention , 1990, Medicine.

[26]  J. Lane,et al.  Osteoporosis: current modes of prevention and treatment. , 1999, The Journal of the American Academy of Orthopaedic Surgeons.

[27]  A. Skolnick 'Female athlete triad' risk for women. , 1993, JAMA.

[28]  P. Delmas,et al.  Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: the OFELY study. , 2003, Bone.

[29]  C. Zerbini,et al.  Risk Factors for Proximal Femur Osteoporosis in Men Aged 50 Years or Older , 2001, Osteoporosis International.

[30]  G. Chrousos,et al.  Bone mineral density in women with depression. , 1996, The New England journal of medicine.

[31]  S. Jaglal,et al.  Validation of the Simple Calculated Osteoporosis Risk Estimation (SCORE) for Patient Selection for Bone Densitometry , 1999, Osteoporosis International.

[32]  B. Edwards,et al.  Barriers and solutions to osteoporosis care in patients with a hip fracture. , 2003, The Journal of bone and joint surgery. American volume.

[33]  K. Tsai,et al.  A Simple Tool to Identify Asian Women at Increased Risk of Osteoporosis , 2001, Osteoporosis International.

[34]  J. Skedros,et al.  The orthopedist as clinical densitometrist: cost- and time-effectiveness. , 2007, American journal of orthopedics.

[35]  M. Gardner,et al.  Improvement in the Undertreatment of Osteoporosis Following Hip Fracture , 2002, The Journal of bone and joint surgery. American volume.

[36]  T. O’Neill,et al.  Frequency and causes of osteoporosis in men. , 2003, Rheumatology.

[37]  C. Marcocci,et al.  Magnitude and Impact of Osteoporosis and Fractures , 2006 .

[38]  P. Guggenbuhl,et al.  Osteoporotic fractures of the proximal humerus, pelvis, and ankle: epidemiology and diagnosis. , 2005, Joint, bone, spine : revue du rhumatisme.

[39]  M. Elmantaser,et al.  Secondary osteoporosis. , 2009, Endocrine development.

[40]  P. Geusens,et al.  Performance of risk indices for identifying low bone density in postmenopausal women. , 2002, Mayo Clinic proceedings.

[41]  Richard Goldstein,et al.  Regression Methods in Biostatistics: Linear, Logistic, Survival and Repeated Measures Models , 2006, Technometrics.

[42]  F. Scott,et al.  A Cross‐Sectional Study of Smoking and Bone Mineral Density in Premenopausal Parous Women: Effect of Body Mass Index, Breastfeeding, and Sports Participation , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[43]  David W. Hosmer,et al.  Applied Logistic Regression , 1991 .

[44]  E. Seeman,et al.  Osteoporosis in Men , 1999, Osteoporosis International.

[45]  O. Johnell,et al.  Mortality, Morbidity, and Assessment of Fracture Risk in Male Osteoporosis , 2001, Calcified Tissue International.

[46]  S. Cummings,et al.  Epidemiology and outcomes of osteoporotic fractures , 2002, The Lancet.

[47]  W A Ray,et al.  Benzodiazepines of long and short elimination half-life and the risk of hip fracture. , 1989, JAMA.

[48]  C. McMurtry,et al.  Clinical InvestigationsMiscellaneousOsteoporosis in Pulmonary Clinic Patientsa: Does Point-of-Care Screening Predict Central Dual-Energy X-ray Absorptiometry? , 2003 .

[49]  O. Johnell,et al.  Multinational survey of osteoporotic fracture management , 2005, Osteoporosis International.

[50]  G W Sun,et al.  Inappropriate use of bivariable analysis to screen risk factors for use in multivariable analysis. , 1996, Journal of clinical epidemiology.

[51]  D. P. O'connor,et al.  The incidence of fractures and dislocations referred for orthopaedic services in a capitated population. , 2004, The Journal of bone and joint surgery. American volume.

[52]  T. Rönnemaa,et al.  Bone mineral density in patients with type 1 and type 2 diabetes. , 1999, Diabetes care.

[53]  J. Treasure,et al.  Osteoporosis in young people. Research and treatment in eating disorders. , 2001, The Psychiatric clinics of North America.

[54]  E. Barrett-Connor,et al.  Bone mineral density thresholds for pharmacological intervention to prevent fractures. , 2004, Archives of internal medicine.

[55]  J. Eisman,et al.  Mortality after all major types of osteoporotic fracture in men and women: an observational study , 1999, The Lancet.

[56]  O. Johnell,et al.  Orthopaedic surgeons and fragility fractures. A survey by the Bone and Joint Decade and the International Osteoporosis Foundation. , 2004, The Journal of bone and joint surgery. British volume.

[57]  O. Johnell,et al.  Ten Year Probabilities of Osteoporotic Fractures According to BMD and Diagnostic Thresholds , 2001, Osteoporosis International.

[58]  C. Cooper,et al.  Use of inhaled corticosteroids and risk of fractures. , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.