Correlation of Hippocampal Neuronal Density and FDG‐PET in Mesial Temporal Lobe Epilepsy

Summary: Purpose: Interictal [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) reveals regional hypometabolism in 60–80% of patients with mesial temporal lobe epilepsy (MTLE). The extent of hypometabolism generally extends beyond the epileptogenic zone. The pathophysiology underlying this widespread change is unknown. This study evaluated the relation between hippocampal neuronal loss and hypometabolism in patients with MTLE.

[1]  C R Jack,et al.  Magnetic resonance image–based hippocampal volumentry: Correlation with outcome after temporal lobectomy , 1992, Annals of neurology.

[2]  H G Wieser,et al.  Mesiobasal versus lateral temporal lobe epilepsy , 1993, Neurology.

[3]  E. Hoffman,et al.  Quantitation in positron emission computed tomography: 2. Effects of inaccurate attenuation correction. , 1979, Journal of computer assisted tomography.

[4]  I Savic,et al.  Pattern of interictal hypometabolism in PET scans with fludeoxyglucose F 18 reflects prior seizure types in patients with mesial temporal lobe seizures. , 1997, Archives of neurology.

[5]  J. Mazziotta,et al.  Interictal metabolic anatomy of mesial temporal lobe epilepsy. , 1993, Archives of neurology.

[6]  J. Mazziotta,et al.  Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy , 1994, Annals of neurology.

[7]  M. Abercrombie.  Estimation of nuclear population from microtome sections , 1946, The Anatomical record.

[8]  Barbara Crain,et al.  Fast Spin‐Echo, Magnetic Resonance Imaging‐Measured Hippocampal Volume: Correlation with Neuronal Density in Anterior Temporal Lobectomy Patients , 1995, Epilepsia.

[9]  K. A. Frey,et al.  Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy , 1995, Neurology.

[10]  M. Newton,et al.  Hippocampal Atrophy Is Not a Major Determinant of Regional Hypometabolism in Temporal Lobe Epilepsy , 1997, Epilepsia.

[11]  J C Mazziotta,et al.  Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes , 1982, Annals of neurology.

[12]  A. Saykin,et al.  Predictors of outcome after anterior temporal lobectomy , 1994, Neurology.

[13]  E. Hoffman,et al.  Quantitation in Positron Emission Computed Tomography: 1. Effect of Object Size , 1979, Journal of computer assisted tomography.

[14]  J H Kim,et al.  Imaging findings in hippocampal sclerosis: correlation with pathology. , 1991, AJNR. American journal of neuroradiology.

[15]  Conrad V. Kufta,et al.  Temporal lobectomy for uncontrolled seizures: The role of positron emission tomography , 1992, Annals of neurology.

[16]  S Gilman,et al.  Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin , 1990, Neurology.

[17]  Gregory McCarthy,et al.  Quantitative magnetic resonance imaging in temporal lobe epilepsy: Relationship to neuropathology and neuropsychological function , 1992, Annals of neurology.

[18]  E. Bromfield,et al.  The dynamics of metabolic change following seizures as measured by positron emission tomography with fludeoxyglucose F 18. , 1994, Archives of neurology.

[19]  D. Hasboun,et al.  Is Interictal Temporal Hypometabolism Related to Mesial Temporal Sclerosis? A Positron Emission Tomography/Magnetic Resonance Imaging Confrontation , 1995, Epilepsia.

[20]  R. Coleman,et al.  Temporal lobe hypometabolism on PET , 1993, Neurology.