Galectin-3: mediator of microglia responses in injured brain.

[1]  N. Derugin,et al.  Genetic deletion of galectin-3 enhances neuroinflammation, affects microglial activation and contributes to sub-chronic injury in experimental neonatal focal stroke , 2017, Brain, Behavior, and Immunity.

[2]  J. Priestley,et al.  Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration , 2017, Scientific Reports.

[3]  M. Chopp,et al.  Exosomes in stroke pathogenesis and therapy. , 2016, The Journal of clinical investigation.

[4]  K. Blomgren,et al.  Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. , 2015, Cell reports.

[5]  Dina M M Alsadek,et al.  Galectin-3 as a Potential Target to Prevent Cancer Metastasis , 2015, Clinical Medicine Insights. Oncology.

[6]  K. Bum-Erdene,et al.  Galectin-3 inhibitors: a patent review (2008–present) , 2014, Expert opinion on therapeutic patents.

[7]  R A Swanson,et al.  Targeting microglial activation in stroke therapy: pharmacological tools and gender effects. , 2014, Current medicinal chemistry.

[8]  A. Raz,et al.  Galectin-3 induces cell migration via a calcium-sensitive MAPK/ERK1/2 pathway , 2014, Oncotarget.

[9]  G. Rabinovich,et al.  Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination , 2014, Neurobiology of Disease.

[10]  F. Sohrabji,et al.  Stroke Neuroprotection: Oestrogen and Insulin‐Like Growth Factor‐1 Interactions and the Role of Microglia , 2013, Journal of neuroendocrinology.

[11]  Taekyun Shin,et al.  The pleiotropic effects of galectin-3 in neuroinflammation: a review. , 2013, Acta histochemica.

[12]  J. R. Menezes,et al.  Lack of galectin‐3 speeds Wallerian degeneration by altering TLR and pro‐inflammatory cytokine expressions in injured sciatic nerve , 2013, The European journal of neuroscience.

[13]  M. Prinz,et al.  Factors regulating microglia activation , 2013, Front. Cell. Neurosci..

[14]  R. Dempsey,et al.  Galectin-3 enhances angiogenic and migratory potential of microglial cells via modulation of integrin linked kinase signaling , 2013, Brain Research.

[15]  Ukpong B. Eyo,et al.  Effects of oxygen‐glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues , 2012, Glia.

[16]  Sachiko Sato,et al.  Galectin-3 Is Required for Resident Microglia Activation and Proliferation in Response to Ischemic Injury , 2012, The Journal of Neuroscience.

[17]  E. Hoffman,et al.  Deletion of galectin-3 exacerbates microglial activation and accelerates disease progression and demise in a SOD1G93A mouse model of amyotrophic lateral sclerosis , 2012, Brain and behavior.

[18]  R. Ransohoff,et al.  Innate immunity in the central nervous system. , 2012, The Journal of clinical investigation.

[19]  N. Arsenijević,et al.  The roles of Galectin-3 in autoimmunity and tumor progression , 2012, Immunologic research.

[20]  H. Kitagawa,et al.  Calcineurin Inhibitors Suppress Cytokine Production from Memory T Cells and Differentiation of Naïve T Cells into Cytokine-Producing Mature T Cells , 2012, PloS one.

[21]  S. David,et al.  Repertoire of microglial and macrophage responses after spinal cord injury , 2011, Nature Reviews Neuroscience.

[22]  A. Karlsson,et al.  Galectin-3 contributes to neonatal hypoxic–ischemic brain injury , 2010, Neurobiology of Disease.

[23]  J. Dennis,et al.  Adaptive Regulation at the Cell Surface by N‐Glycosylation , 2009, Traffic.

[24]  R. Dempsey,et al.  Galectin-3 mediates post-ischemic tissue remodeling , 2009, Brain Research.

[25]  Julie Nieminen,et al.  Galectins in innate immunity: dual functions of host soluble β‐galactoside‐binding lectins as damage‐associated molecular patterns (DAMPs) and as receptors for pathogen‐associated molecular patterns (PAMPs) , 2009, Immunological reviews.

[26]  N. Henderson,et al.  The regulation of inflammation by galectin‐3 , 2009, Immunological reviews.

[27]  S. Rotshenker The Role of Galectin-3/MAC-2 in the Activation of the Innate-Immune Function of Phagocytosis in Microglia in Injury and Disease , 2009, Journal of Molecular Neuroscience.

[28]  J. Kriz,et al.  Inflammation, plasticity and real-time imaging after cerebral ischemia , 2009, Acta Neuropathologica.

[29]  O. Lindvall,et al.  Brain inflammation and adult neurogenesis: The dual role of microglia , 2009, Neuroscience.

[30]  D. Hsu,et al.  Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation1 , 2008, The Journal of Immunology.

[31]  G. Rabinovich,et al.  Galectins: structure, function and therapeutic potential , 2008, Expert Reviews in Molecular Medicine.

[32]  S. Forbes,et al.  Regulation of Alternative Macrophage Activation by Galectin-31 , 2008, The Journal of Immunology.

[33]  Sachiko Sato,et al.  Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae1 , 2008, The Journal of Immunology.

[34]  J. Dennis,et al.  Complex N-glycan and metabolic control in tumor cells. , 2007, Cancer research.

[35]  G. Rabinovich,et al.  Functions of cell surface galectin-glycoprotein lattices. , 2007, Current opinion in structural biology.

[36]  I. Torres-Aleman,et al.  Calcineurin in Reactive Astrocytes Plays a Key Role in the Interplay between Proinflammatory and Anti-Inflammatory Signals , 2007, The Journal of Neuroscience.

[37]  G. Rabinovich,et al.  An Emerging Role for Galectins in Tuning the Immune Response: Lessons from Experimental Models of Inflammatory Disease, Autoimmunity and Cancer , 2007, Scandinavian journal of immunology.

[38]  G. Gowing,et al.  Selective Ablation of Proliferating Microglial Cells Exacerbates Ischemic Injury in the Brain , 2007, The Journal of Neuroscience.

[39]  G. Rabinovich,et al.  Dissecting the pathophysiologic role of endogenous lectins: glycan-binding proteins with cytokine-like activity? , 2007, Cytokine & growth factor reviews.

[40]  P. Weinstein,et al.  Chronic Treatment With Minocycline Preserves Adult New Neurons and Reduces Functional Impairment After Focal Cerebral Ischemia , 2007, Stroke.

[41]  Mirna Flögel,et al.  Galectin-3: an open-ended story. , 2006, Biochimica et biophysica acta.

[42]  Maria K. Lehtinen,et al.  The Transcription Factor NFAT3 Mediates Neuronal Survival* , 2005, Journal of Biological Chemistry.

[43]  A. Saito,et al.  Oxidative Stress Affects the Integrin-Linked Kinase Signaling Pathway After Transient Focal Cerebral Ischemia , 2004, Stroke.

[44]  J. Dennis,et al.  Regulation of Cytokine Receptors by Golgi N-Glycan Processing and Endocytosis , 2004, Science.

[45]  Y. Takenaka,et al.  Galectin-3, a Novel Binding Partner of β-Catenin , 2004, Cancer Research.

[46]  Y. Kloog,et al.  Galectin-3 Augments K-Ras Activation and Triggers a Ras Signal That Attenuates ERK but Not Phosphoinositide 3-Kinase Activity* , 2004, Journal of Biological Chemistry.

[47]  Hiroki Toda,et al.  Inflammatory Blockade Restores Adult Hippocampal Neurogenesis , 2003, Science.

[48]  S. Seki,et al.  Stimulation of Proliferation of Rat Hepatic Stellate Cells by Galectin-1 and Galectin-3 through Different Intracellular Signaling Pathways* , 2003, Journal of Biological Chemistry.

[49]  A. Raz,et al.  Galectin-3 enhances cyclin D1 promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells , 2002, Oncogene.

[50]  T. Yoshii,et al.  Galectin-3 Phosphorylation Is Required for Its Anti-apoptotic Function and Cell Cycle Arrest* , 2002, The Journal of Biological Chemistry.

[51]  P. Ricciardi-Castagnoli,et al.  Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles1 , 2001, The Journal of Immunology.

[52]  G. Romeo,et al.  Role of galectin-3 as a receptor for advanced glycosylation end products. , 2000, Kidney international. Supplement.

[53]  R. Hughes Secretion of the galectin family of mammalian carbohydrate-binding proteins. , 1999, Biochimica et biophysica acta.

[54]  Y. Honjo,et al.  The NH2 terminus of galectin-3 governs cellular compartmentalization and functions in cancer cells. , 1999, Cancer research.

[55]  R. Hughes,et al.  Determinants in the N-terminal domains of galectin-3 for secretion by a novel pathway circumventing the endoplasmic reticulum-Golgi complex. , 1999, European journal of biochemistry.

[56]  Sucai Dong,et al.  Galectin‐3 stimulates uptake of extracellular Ca2+ in human Jurkat T‐cells , 1996, FEBS letters.

[57]  S. Sato,et al.  Regulation of secretion and surface expression of Mac-2, a galactoside-binding protein of macrophages. , 1994, The Journal of biological chemistry.

[58]  Sarah L. Farnworth,et al.  Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. , 2012, American journal of respiratory and critical care medicine.