Chromosome-Positive Chronic Myeloid Leukemia Expressing pi 90 BC *-AM '

We describe a case of Philadelphia chromosome-positive chronic myeloid leukemia (Ph-positive CML)expressing pl90BCTAfiL. Reverse transcription-polymerase chain reaction (RT-PCR) analysis of bone marrow cells showed a 472-bp band using primers specific for the pl90*c* ABLbut not \)210PCRmABL transcript. Sequencing analysis revealed that the PCR product was derived from the fusion between BCR exon el and ABLexon a2 (ela2). CMLexpressing pl90*c*" ABLis relatively rare. In a review of the literature, it may be grouped into 2 categories; approximately half of the patients exhibited prominent monocytosis and intermediate hematological phenotype between CMLand chronic myelomonocytic leukemia, and the remaining patients showed no monocytosis. (Internal Medicine 41: 1183-1187, 2002)

[1]  T. Miyazaki,et al.  Chronic myeloid leukemia presenting ALL-type BCR/ABL transcript , 1994, Annals of Hematology.

[2]  H. Kantarjian,et al.  Chronic myelogenous leukaemia with p185BCR/ABL expression: characteristics and clinical significance , 1999, British journal of haematology.

[3]  SFT Thijsen,et al.  Chronic myeloid leukemia from basics to bedside , 1999, Leukemia.

[4]  George Q. Daley,et al.  The P190, P210, and P230 Forms of the BCR/ABL Oncogene Induce a Similar Chronic Myeloid Leukemia–like Syndrome in Mice but Have Different Lymphoid Leukemogenic Activity , 1999, The Journal of experimental medicine.

[5]  K. Inokuchi,et al.  Extramedullary presentation of chronic myelogenous leukemia with p190 BCR/ABL transcripts. , 1998, Cancer genetics and cytogenetics.

[6]  T. Ohno,et al.  Chronic myeloid leukemia with minor‐bcr breakpoint developed hybrid type of blast crisis , 1998, American journal of hematology.

[7]  G. Martinelli,et al.  BCR/ABL transcripts and leukemia phenotype: an unsolved puzzle. , 1997, Leukemia & lymphoma.

[8]  J. Melo,et al.  The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype. , 1996, Blood.

[9]  G. Meloni,et al.  Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction) , 1996, Blood.

[10]  R. Bouabdallah,et al.  Minor breakpoint cluster region (m‐BCR) positive chronic myeloid leukaemia with an acute lymphoblastic leukaemia onset: a case report , 1995, British journal of haematology.

[11]  J. Melo,et al.  P190BCR-ABL chronic myeloid leukaemia: the missing link with chronic myelomonocytic leukaemia? , 1994, Leukemia.

[12]  N. Aoki,et al.  Consistent involvement of the 3’half part of the first BCR intron in adult Philadelphia‐positive leukaemia without M‐bcr rearrangement , 1993, British journal of haematology.

[13]  M. Campbell,et al.  Acute lymphoid leukemia molecular phenotype in a patient with benign-phase chronic myelogenous leukemia. , 1993, Hematologic pathology.

[14]  G. Saglio,et al.  Alternative BCR/ABL transcripts in chronic myeloid leukemia. , 1990, Blood.

[15]  G. Grosveld,et al.  Chronic myeloid leukemia may be associated with several bcr-abl transcripts including the acute lymphoid leukemia-type 7 kb transcript. , 1990, Blood.

[16]  O. Witte,et al.  Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells , 1989, Molecular and cellular biology.

[17]  K. Yamada,et al.  Multiple primary cancers associated with hematological malignancies. , 1985, Japanese journal of clinical oncology.

[18]  H. Gralnick,et al.  Proposals for the classification of the myelodysplastic syndromes , 1982, British journal of haematology.