Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases.

[1]  A. Sher,et al.  In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. , 1996, Journal of immunology.

[2]  T. Miyoshi‐Akiyama,et al.  Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen. , 1996, Journal of immunology.

[3]  D. Danley,et al.  Defective Rho GTPase regulation by IL-1 beta-converting enzyme-mediated cleavage of D4 GDP dissociation inhibitor. , 1996, Journal of immunology.

[4]  D. Danley,et al.  D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis (*) , 1996, The Journal of Biological Chemistry.

[5]  C. Nobes,et al.  Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia , 1995, Cell.

[6]  R. Shaw,et al.  A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[7]  P. Krammer,et al.  Autocrine T-cell suicide mediated by APO-1/(Fas/CD95) , 1995, Nature.

[8]  A. Lanzavecchia,et al.  Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton , 1995, The Journal of experimental medicine.

[9]  K. Tanaka,et al.  Molecular cloning and characterization of yeast rho GDP dissociation inhibitor. , 1994, The Journal of biological chemistry.

[10]  Mark S. Boguski,et al.  Proteins regulating Ras and its relatives , 1993, Nature.

[11]  C. Adra,et al.  Identification of a novel protein with GDP dissociation inhibitor activity for the ras‐like proteins CDC42Hs and Rac 1 , 1993, Genes, chromosomes & cancer.

[12]  P. Chavrier,et al.  An immunologist's look at the Rho and Rab GTP-binding proteins. , 1993, Immunology today.

[13]  L. Staudt,et al.  Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[14]  J. Fukata,et al.  Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho , 1993, The Journal of cell biology.

[15]  J. Lélias,et al.  cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[16]  T. Sasaki,et al.  Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility , 1993, Molecular and cellular biology.

[17]  D. Kioussis,et al.  Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[18]  M. Tremblay,et al.  Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[19]  R. Stancou,et al.  ADP-ribosylation of the ras-related, GTP-binding protein RhoA inhibits lymphocyte-mediated cytotoxicity. , 1992, The Journal of biological chemistry.

[20]  Rudolf Jaenisch,et al.  Targeted mutation of the DNA methyltransferase gene results in embryonic lethality , 1992, Cell.

[21]  K. Kaibuchi,et al.  Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins. , 1992, Biochemical and biophysical research communications.

[22]  P. Matzinger.  The JAM test. A simple assay for DNA fragmentation and cell death. , 1991, Journal of immunological methods.

[23]  T. Watts,et al.  Characterization of the signaling function of MHC class II molecules during antigen presentation by B cells. , 1991, Journal of immunology.

[24]  M. Lenardo.  lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis , 1991, Nature.

[25]  A Valencia,et al.  The ras protein family: evolutionary tree and role of conserved amino acids. , 1991, Biochemistry.

[26]  A. Hall,et al.  The cellular functions of small GTP-binding proteins. , 1990, Science.

[27]  Y. Takai,et al.  Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein. , 1990, The Journal of biological chemistry.

[28]  H. Boehmer,et al.  Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes , 1988, Nature.

[29]  J. Ortaldo,et al.  Standardization of the chromium-51 release, cell-mediated cytotoxicity assay: cryopreservation of mouse effector and target cells. , 1977, Journal of the National Cancer Institute.

[30]  S. Mann,et al.  Ciba Foundation Symposium , 1997 .

[31]  A. Sher,et al.  Induction and regulation of host cell-mediated immunity by Toxoplasma gondii. , 1995, Ciba Foundation symposium.

[32]  Alexandra L. Joyner,et al.  Gene targeting: a practical approach. , 1993 .