MerTK is a novel therapeutic target in gastric cancer
暂无分享,去创建一个
Joon-Oh Park | S. Park | Jeonghee Cho | Kyoung-Mee Kim | M. Hong | I. Do | Jeeyun Lee | H. Lim | S. Kim | W. Kang | Y. Park | Sujin Lee | Ho Yeong Lim | J. Yi | J. Jang
[1] Joon-Oh Park,et al. Phase III Trial to Compare Adjuvant Chemotherapy With Capecitabine and Cisplatin Versus Concurrent Chemoradiotherapy in Gastric Cancer: Final Report of the Adjuvant Chemoradiotherapy in Stomach Tumors Trial, Including Survival and Subset Analyses. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[2] D. Shin,et al. Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial. , 2014, The Lancet. Oncology.
[3] Naotoshi Sugimoto,et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. , 2014, The Lancet. Oncology.
[4] D. Newton,et al. UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor , 2014, Journal of medicinal chemistry.
[5] A. Pierce,et al. MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme , 2014, Oncotarget.
[6] A. Ullrich,et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells , 2014, Nature.
[7] C. Fuchs,et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial , 2014, The Lancet.
[8] Melissa A. Sandahl,et al. MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis. , 2013, The Journal of clinical investigation.
[9] T. Boggon,et al. MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL , 2013, Pigment cell & melanoma research.
[10] S. Frye,et al. UNC1062, a new and potent Mer inhibitor. , 2013, European journal of medicinal chemistry.
[11] G. Ferry,et al. S49076 Is a Novel Kinase Inhibitor of MET, AXL, and FGFR with Strong Preclinical Activity Alone and in Association with Bevacizumab , 2013, Molecular Cancer Therapeutics.
[12] C. Miller,et al. MERTK receptor tyrosine kinase is a therapeutic target in melanoma. , 2013, The Journal of clinical investigation.
[13] H. Earp,et al. Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia , 2013, Oncogene.
[14] W. Franklin,et al. Mer or Axl Receptor Tyrosine Kinase Inhibition Promotes Apoptosis, Blocks Growth, and Enhances Chemosensitivity of Human Non-Small Cell Lung Cancer , 2012, Oncogene.
[15] Bin Tean Teh,et al. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes , 2012, Nature Genetics.
[16] Khay Guan Yeoh,et al. A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets , 2012, Gut.
[17] Anupam Verma,et al. Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors. , 2011, ACS medicinal chemistry letters.
[18] Zhengyan Kan,et al. Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer , 2011, Nature Genetics.
[19] Mindy I. Davis,et al. Comprehensive analysis of kinase inhibitor selectivity , 2011, Nature Biotechnology.
[20] D. Bearss,et al. Targeting Axl and Mer Kinases in Cancer , 2011, Molecular Cancer Therapeutics.
[21] Yoon-Koo Kang,et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial , 2010, The Lancet.
[22] A. Thorburn,et al. Inhibition of Mer and Axl Receptor Tyrosine Kinases in Astrocytoma Cells Leads to Increased Apoptosis and Improved Chemosensitivity , 2010, Molecular Cancer Therapeutics.
[23] A. Luttun,et al. Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6. , 2010, Blood.
[24] Bjørn Tore Gjertsen,et al. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival , 2009, Proceedings of the National Academy of Sciences.
[25] G. Feldmann,et al. The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target , 2009, Cancer biology & therapy.
[26] C. Bokemeyer,et al. Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: a study of the Arbeitsgemeinschaft Internistische Onkologie. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[27] A. Ullrich,et al. Axl and Growth Arrest–Specific Gene 6 Are Frequently Overexpressed in Human Gliomas and Predict Poor Prognosis in Patients with Glioblastoma Multiforme , 2008, Clinical Cancer Research.
[28] E. Birney,et al. Patterns of somatic mutation in human cancer genomes , 2007, Nature.
[29] S. Al-Batran,et al. Chemotherapy for advanced gastric cancer. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[30] H. Seno,et al. Growth arrest‐specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway , 2007, Molecular carcinogenesis.
[31] R. Tisch,et al. Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells. , 2007, Blood.
[32] J. Ajani,et al. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[33] L. Meltesen,et al. Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase , 2006, Oncogene.
[34] H. Snodgrass,et al. Ectopic Expression of the Proto-oncogene Mer in Pediatric T-Cell Acute Lymphoblastic Leukemia , 2006, Clinical Cancer Research.
[35] Stephen T. C. Wong,et al. Multiple roles for the receptor tyrosine kinase axl in tumor formation. , 2005, Cancer research.
[36] D. Cunningham,et al. ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of gastric cancer. , 2005, Annals of oncology : official journal of the European Society for Medical Oncology.
[37] John R. Mackey,et al. Gastric Adenocarcinoma: Review and Considerations for Future Directions , 2005, Annals of surgery.
[38] J. Curtis,et al. The receptor tyrosine kinase MerTK activates phospholipase C γ2 during recognition of apoptotic thymocytes by murine macrophages , 2004, Journal of leukocyte biology.
[39] M. Ehinger,et al. Mantle cell lymphomas express a distinct genetic signature affecting lymphocyte trafficking and growth regulation as compared with subpopulations of normal human B cells. , 2002, Cancer research.
[40] C. Chi,et al. Clinical significance of AXL kinase family in gastric cancer. , 2002, Anticancer research.
[41] R. Scott,et al. Phagocytosis and clearance of apoptotic cells is mediated by MER , 2001, Nature.
[42] J. Weber,et al. Expression of the receptor protein‐tyrosine kinases Tyro‐3, Axl, and Mer in the developing rat central nervous system , 2000, The Journal of comparative neurology.
[43] P. Godowski,et al. Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation , 1997, Oncogene.
[44] H. Kung,et al. Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase , 1995, Molecular and cellular biology.
[45] H. Snodgrass,et al. Cloning and Mrna Expression Analysis of a Novel Human Protooncogene, C-merr , 2022 .
[46] B. Mayer,et al. A novel oncogene, v-ryk, encoding a truncated receptor tyrosine kinase is transduced into the RPL30 virus without loss of viral sequences , 1992, Journal of virology.
[47] H. Earp,et al. TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. , 2008, Advances in cancer research.
[48] Stage Iiia,et al. ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of gastric cancer , 2005 .
[49] D. Bereczki,et al. The Cochrane Database of Systematic Reviews , 2003 .
[50] HighWire Press. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. , 2002 .
[51] H. Kung,et al. Protein-tyrosine kinase and protein-serine/threonine kinase expression in human gastric cancer cell lines. , 1998, Journal of biomedical science.