Development of Animal Model of Heat syndrome Due to Insufficiency of Yin Fluids

Objective:To improve the present animal model of heat syndrome due to insufficiency of Yin fluids.Methods:Decoction of Chinese herbal drugs that induce heat sydrome due to insufficiency of Yin fluids was administered to the rats for 28 days in 6～8 times dosage used in the previous experiments,and the appearances,picture of tongue,stool,and stimulated defecation were observed and organ indexes(wet weight of organ/body weight)of some organs,body weight,temperature,food and drink amount,swimming duration,and the biochemical indexes related to heat syndrome due to insufficiency of Yin fluids were determined at different time.Results:The rats had the manifestations of heat syndrome,as well as the manifestations of deficiency syndrome in varying degrees.Conclusion:This method of developing heat syndrome due to insufficiency of Yin fluids has some advantages,however,it needs to be further improved.