ReviewIntravital Microscopy : Visualizing Immunity in Context

[1]  J. Mora,et al.  In vivo imaging of leukocyte trafficking in blood vessels and tissues. , 2004, Current opinion in immunology.

[2]  Takashi Nagasawa,et al.  Cellular niches controlling B lymphocyte behavior within bone marrow during development. , 2004, Immunity.

[3]  S. Tangye,et al.  From bloodjournal.hematologylibrary.org at PENN STATE UNIVERSITY on February 23, 2013. For personal use only. , 2002 .

[4]  B. John,et al.  Passive and Active Mechanisms Trap Activated CD8+ T Cells in the Liver1 , 2004, The Journal of Immunology.

[5]  Mark M Davis,et al.  T cell killing does not require the formation of a stable mature immunological synapse , 2004, Nature Immunology.

[6]  Michael Loran Dustin,et al.  LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. , 2004, Immunity.

[7]  U. V. von Andrian,et al.  Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. , 2004, Annual review of immunology.

[8]  R. Steinman,et al.  In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination , 2004, The Journal of experimental medicine.

[9]  Mark J. Miller,et al.  T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[10]  R. Proia,et al.  Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 , 2004, Nature.

[11]  S. Henrickson,et al.  T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases , 2004, Nature.

[12]  L. Moreland Memory B lymphocytes , 2004 .

[13]  E. Scarpini,et al.  RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing. , 2004, Immunity.

[14]  M. Feuerer,et al.  T-cell priming in bone marrow: the potential for long-lasting protective anti-tumor immunity. , 2003, Trends in molecular medicine.

[15]  Mark M Davis,et al.  Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. , 2003, Molecular cell.

[16]  J. Segall,et al.  Intravital imaging of cell movement in tumours , 2003, Nature Reviews Cancer.

[17]  Mark M. Davis,et al.  T-cell-antigen recognition and the immunological synapse , 2003, Nature Reviews Immunology.

[18]  C. Larsen,et al.  Intravital microscopy identifies selectins that regulate T cell traffic into allografts. , 2003, The Journal of clinical investigation.

[19]  Clemens Utzny,et al.  Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: Manifestation of a dual activation threshold , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[20]  Peter Friedl,et al.  Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases. , 2003, Blood.

[21]  Ulrich H. von Andrian,et al.  Homing and cellular traffic in lymph nodes , 2003, Nature Reviews Immunology.

[22]  D. Scadden,et al.  Osteoblastic cells regulate the haematopoietic stem cell niche , 2003, Nature.

[23]  Haiyang Huang,et al.  Identification of the haematopoietic stem cell niche and control of the niche size , 2003, Nature.

[24]  K. Wennerberg,et al.  Integrin signaling to the actin cytoskeleton. , 2003, Current opinion in cell biology.

[25]  G. Belz,et al.  Epidermal Viral Immunity Induced by CD8α+ Dendritic Cells But Not by Langerhans Cells , 2003, Science.

[26]  P. Frenette,et al.  PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin. , 2003, Blood.

[27]  Mark J. Miller,et al.  A stochastic view of lymphocyte motility and trafficking within the lymph node , 2003, Immunological reviews.

[28]  M. Feuerer,et al.  Bone marrow as a priming site for T-cell responses to blood-borne antigen , 2003, Nature Medicine.

[29]  L. Erickson,et al.  The rise and fall of long‐lived humoral immunity: terminal differentiation of plasma cells in health and disease , 2003, Immunological reviews.

[30]  M. Potter Neoplastic development in plasma cells , 2003, Immunological reviews.

[31]  P. Richardson,et al.  Novel therapeutic approaches for multiple myeloma , 2003, Immunological reviews.

[32]  M. Jenkins,et al.  Antigen presentation to naive CD4 T cells in the lymph node , 2003, Nature Immunology.

[33]  Simon C Watkins,et al.  Multimodal optical imaging. , 2003, American journal of physiology. Lung cellular and molecular physiology.

[34]  R. Zaru,et al.  Cutting Edge: T Lymphocyte Activation by Repeated Immunological Synapse Formation and Intermittent Signaling 1 , 2003, The Journal of Immunology.

[35]  Mark M Davis,et al.  Continuous T cell receptor signaling required for synapse maintenance and full effector potential , 2003, Nature Immunology.

[36]  A. Rudensky,et al.  Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. , 2003, Immunity.

[37]  Philippe Bousso,et al.  Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes , 2003, Nature Immunology.

[38]  D. Broide,et al.  A murine model to study leukocyte rolling and intravascular trafficking in lung microvessels. , 2003, The American journal of pathology.

[39]  R. Hotchkiss,et al.  Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node. , 2003, American journal of physiology. Heart and circulatory physiology.

[40]  Stephen P. Schoenberger,et al.  Dynamic programming of CD8+ T lymphocyte responses , 2003, Nature Immunology.

[41]  A. Santoni,et al.  Memory T-cell competition for bone marrow seeding , 2003, Immunology.

[42]  Mark J. Miller,et al.  Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Iannis Aifantis,et al.  Thymic selection revisited: how essential is it? , 2003, Immunological reviews.

[44]  David M Kranz,et al.  Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. , 2003, Immunity.

[45]  T. Mayadas,et al.  The Clearance Mechanism of Chilled Blood Platelets , 2003, Cell.

[46]  R. Germain,et al.  Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes , 2002, Nature.

[47]  Michael D. Cahalan,et al.  Two-photon tissue imaging: seeing the immune system in a fresh light , 2002, Nature Reviews Immunology.

[48]  Scott N. Mueller,et al.  The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens , 2002, The Journal of experimental medicine.

[49]  U. V. von Andrian,et al.  Travellers in many guises: The origins and destinations of dendritic cells , 2002, Immunology and cell biology.

[50]  A. Santoni,et al.  Bone marrow CD8 T cells are in a different activation state than those in lymphoid periphery , 2002, European journal of immunology.

[51]  J. Cyster,et al.  Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches , 2002, The Journal of experimental medicine.

[52]  R. Germain,et al.  Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes , 2002, Science.

[53]  Philippe Bousso,et al.  Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy , 2002, Science.

[54]  U. V. von Andrian,et al.  Total body irradiation causes profound changes in endothelial traffic molecules for hematopoietic progenitor cell recruitment to bone marrow. , 2002, Blood.

[55]  Mark J. Miller,et al.  Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node , 2002, Science.

[56]  Michael Loran Dustin,et al.  The immunological synapse , 2002, Arthritis research.

[57]  Dai Fukumura,et al.  Dissecting tumour pathophysiology using intravital microscopy , 2002, Nature Reviews Cancer.

[58]  H. Ishii,et al.  Intravital observation of adhesion of lamina propria lymphocytes to microvessels of small intestine in mice. , 2002, Gastroenterology.

[59]  Michael Loran Dustin,et al.  T Cell Receptor Signaling Precedes Immunological Synapse Formation , 2002, Science.

[60]  R. Germain,et al.  Self-recognition and the regulation of CD4+ T cell survival. , 2002, Advances in experimental medicine and biology.

[61]  Irving L. Weissman,et al.  Physiological Migration of Hematopoietic Stem and Progenitor Cells , 2001, Science.

[62]  Steffen Jung,et al.  Inflammatory Chemokine Transport and Presentation in HEV , 2001, The Journal of experimental medicine.

[63]  Wolfgang Weninger,et al.  Migratory Properties of Naive, Effector, and Memory Cd8+ T Cells , 2001, The Journal of experimental medicine.

[64]  B. Engelhardt,et al.  Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. , 2001, The Journal of clinical investigation.

[65]  M. Neuberger,et al.  B cells acquire antigen from target cells after synapse formation , 2001, Nature.

[66]  P. Doherty,et al.  Measuring the diaspora for virus-specific CD8+ T cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[67]  S. Nilsson,et al.  Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches. , 2001, Blood.

[68]  G. Bastert,et al.  Enrichment of memory T cells and other profound immunological changes in the bone marrow from untreated breast cancer patients , 2001, International journal of cancer.

[69]  J. Cyster,et al.  Chemokines in lymphopoiesis and lymphoid organ development. , 2001, Current opinion in immunology.

[70]  G. Bastert,et al.  Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow , 2001, Nature Medicine.

[71]  C. Mackay,et al.  Chemokines: immunology's high impact factors , 2001, Nature Immunology.

[72]  S. Bromley,et al.  The immunological synapse. , 2001, Annual review of immunology.

[73]  M. Bevan,et al.  Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo , 2000, The Journal of experimental medicine.

[74]  P. Kubes,et al.  A Role for Platelets and Endothelial Selectins in Tumor Necrosis Factor-&agr;–Induced Leukocyte Recruitment in the Brain Microvasculature , 2000, Circulation research.

[75]  Michael Loran Dustin,et al.  Signaling Takes Shape in the Immune System , 2000, Cell.

[76]  C. Mackay,et al.  T-cell function and migration. Two sides of the same coin. , 2000, The New England journal of medicine.

[77]  E. Bröcker,et al.  Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. , 2000, Immunity.

[78]  J. Schmitz,et al.  Simian immunodeficiency virus-specific cytotoxic T lymphocytes and cell-associated viral RNA levels in distinct lymphoid compartments of SIVmac-infected rhesus monkeys. , 2000, Blood.

[79]  Fadi G Lakkis,et al.  Immunologic ‘ignorance’ of vascularized organ transplants in the absence of secondary lymphoid tissue , 2000, Nature Medicine.

[80]  N. Ohshima,et al.  A new model of lung metastasis for intravital studies. , 2000, Microvascular research.

[81]  T. Abo,et al.  Physiological responses of extrathymic T cells in the liver , 2000, Immunological reviews.

[82]  U. V. von Andrian,et al.  The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function–Associated Antigen 1–Mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules , 2000, The Journal of experimental medicine.

[83]  C Caux,et al.  Immunobiology of dendritic cells. , 2000, Annual review of immunology.

[84]  F. Sallusto,et al.  Two subsets of memory T lymphocytes with distinct homing potentials and effector functions , 1999, Nature.

[85]  Heikyung Suh,et al.  Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion , 1999, Nature.

[86]  S. Bromley,et al.  The immunological synapse: a molecular machine controlling T cell activation. , 1999, Science.

[87]  I. Mazo,et al.  Adhesion and homing of blood‐borne cells in bone marrow microvessels , 1999, Journal of leukocyte biology.

[88]  N. Hogg,et al.  Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice , 1999, The Journal of experimental medicine.

[89]  J. Cyster,et al.  Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells. , 1999, Science.

[90]  Paul W Price,et al.  Characterization of CD4+ T cells in mouse bone marrow. I. Increased activated/memory phenotype and altered TCR Vβ repertoire , 1999, European journal of immunology.

[91]  Adrian L. Smith,et al.  Antigen-pulsed CD8α+ Dendritic Cells Generate an Immune Response after Subcutaneous Injection without Homing to the Draining Lymph Node , 1999, The Journal of experimental medicine.

[92]  Gargi Maheshwari,et al.  Deconstructing (and reconstructing) cell migration , 1998, Microscopy research and technique.

[93]  Colin R. F. Monks,et al.  Three-dimensional segregation of supramolecular activation clusters in T cells , 1998, Nature.

[94]  Richard O. Hynes,et al.  Hematopoietic Progenitor Cell Rolling in Bone Marrow Microvessels: Parallel Contributions by Endothelial Selectins and Vascular Cell Adhesion Molecule 1 , 1998, The Journal of experimental medicine.

[95]  M. Naramura,et al.  Mice with a fluorescent marker for interleukin 2 gene activation. , 1998, Immunity.

[96]  B. Edgar,et al.  Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing , 1998, Nature.

[97]  K. Messmer,et al.  A novel model for the study of synovial microcirculation in the mouse knee joint in vivo , 1998, Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.

[98]  A. Beaudet,et al.  Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice , 1998, The Journal of experimental medicine.

[99]  E. Ruoslahti,et al.  β1 Integrins Are Critically Involved in Neutrophil Locomotion in Extravascular Tissue In Vivo , 1998, The Journal of experimental medicine.

[100]  G. Bokoch,et al.  Two Signaling Mechanisms for Activation of αMβ2 Avidity in Polymorphonuclear Neutrophils* , 1998, The Journal of Biological Chemistry.

[101]  R. Ahmed,et al.  Humoral immunity due to long-lived plasma cells. , 1998, Immunity.

[102]  E. Butcher,et al.  Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes , 1998, The Journal of experimental medicine.

[103]  E. Butcher,et al.  Chemokines and the arrest of lymphocytes rolling under flow conditions. , 1998, Science.

[104]  P. L. Bergsagel,et al.  Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process , 1998 .

[105]  K. Messmer,et al.  Platelet-Endothelial Cell Interactions During Ischemia / Reperfusion : The Role of P-Selectin , 1998 .

[106]  James J. Campbell,et al.  Multistep Navigation and the Combinatorial Control of Leukocyte Chemotaxis , 1997, The Journal of cell biology.

[107]  R. Ahmed,et al.  Bone marrow contains virus-specific cytotoxic T lymphocytes. , 1997, Blood.

[108]  Andreas Radbruch,et al.  Lifetime of plasma cells in the bone marrow , 1997, Nature.

[109]  P. Doherty,et al.  Bone marrow can function as a lymphoid organ during a primary immune response under conditions of disrupted lymphocyte trafficking. , 1997, Journal of immunology.

[110]  D A Peterson,et al.  Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[111]  M. Saxton Single-particle tracking: the distribution of diffusion coefficients. , 1997, Biophysical journal.

[112]  Stephen Shaw,et al.  Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex , 1997, Immunological reviews.

[113]  S. Morini,et al.  SEM corrosion‐casts study of the microcirculation of the flat bones in the rat , 1997, The Anatomical record.

[114]  M. Cooper,et al.  Memory B lymphocytes migrate to bone marrow in humans. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[115]  T. Honjo,et al.  Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice. , 1996, International immunology.

[116]  L. Picker,et al.  Lymphocyte Homing and Homeostasis , 1996, Science.

[117]  T. Mak,et al.  LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor , 1996, The Journal of experimental medicine.

[118]  M. Miyazaki,et al.  Mechanisms of interleukin-2-induced hepatic toxicity. , 1996, Cancer research.

[119]  U. V. von Andrian Intravital microscopy of the peripheral lymph node microcirculation in mice. , 1996, Microcirculation.

[120]  Intravital measurement of donor lymphocyte adhesion to islet endothelium of recipient animals in diabetes transfer experiments. , 2009, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[121]  J. Bluestone,et al.  Development of TCR gamma delta iIELs. , 1995, Seminars in immunology.

[122]  E. Butcher,et al.  Distinct roles of L-selectin and integrins α4β7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined , 1995 .

[123]  E. Berg,et al.  Rolling of lymphocytes and neutrophils on peripheral node addressin and subsequent arrest on ICAM‐1 in shear flow , 1995, European journal of immunology.

[124]  M. Menger,et al.  New model for the study of the microcirculation of islet grafts in hairless and nude mice. , 1994, Transplantation proceedings.

[125]  T. Springer Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm , 1994, Cell.

[126]  Daniel J. Gauthier,et al.  The Two-Photon Laser , 1994 .

[127]  E. Berg,et al.  L-selectin-mediated lymphocyte rolling on MAdCAM-1 , 1993, Nature.

[128]  A. Beaudet,et al.  Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[129]  R. Jain,et al.  Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. , 1992, Cancer research.

[130]  E. Butcher Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity , 1991, Cell.

[131]  P. Streeter,et al.  The influence of afferent lymphatic vessel interruption on vascular addressin expression , 1991, The Journal of cell biology.

[132]  W. Denk,et al.  Two-photon laser scanning fluorescence microscopy. , 1990, Science.

[133]  Michael L. Dustin,et al.  T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1 , 1989, Nature.

[134]  E. Kaiserling,et al.  In Situ immunophenotyping of lymphocytes in human bone marrow: an immunohistochemical study , 1989, British journal of haematology.

[135]  D. Opstelten,et al.  An in situ study of B-lymphocytopoiesis in rat bone marrow. Topographical arrangement of terminal deoxynucleotidyl transferase-positive cells and pre-B cells. , 1989, Journal of immunology.

[136]  G. Kraal,et al.  Rapid decrease in lymphocyte adherence to high endothelial venules in lymph nodes deprived of afferent lymphatic vessels , 1987, European journal of immunology.

[137]  L V McIntire,et al.  Effect of flow on polymorphonuclear leukocyte/endothelial cell adhesion. , 1987, Blood.

[138]  D. G. Osmond,et al.  Population Dynamics of Bone Marrow B Lymphocytes , 1986, Immunological reviews.

[139]  M. Robson,et al.  Acute effects of tobacco smoking on blood flow in the cutaneous micro-circulation. , 1984, British journal of plastic surgery.

[140]  E. Rofstad,et al.  A transparent chamber for the dorsal skin fold of athymic mice. , 1984, Experimental cell biology.

[141]  T. Springer,et al.  Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions. , 1981, Journal of immunology.

[142]  B. Nikolaus,et al.  Two-Photon Laser , 1981 .

[143]  T. Mandel,et al.  The differentiation of murine thymocytes in vivo and in vitro. , 1978, Immunology.

[144]  L. Lajtha,et al.  Conditions controlling the proliferation of haemopoietic stem cells in vitro , 1977, Journal of cellular physiology.

[145]  J. Hendry,et al.  The relative spatial distributions of CFUs and CFUc in the normal mouse femur. , 1975, Blood.

[146]  S. Baez,et al.  An open cremaster muscle preparation for the study of blood vessels by in vivo microscopy. , 1973, Microvascular research.

[147]  G. Born,et al.  Quantitative investigations of the adhesiveness of circulating polymorphonuclear leucocytes to blood vessel walls , 1972, The Journal of physiology.

[148]  R. McCuskey,et al.  Microscopy of living bone marrow in situ. , 1971, Blood.

[149]  P. Branemark Vital microscopy of bone marrow in rabbit. , 1959, Scandinavian journal of clinical and laboratory investigation.

[150]  POUL BROBERG,et al.  Quantitative investigation , 1944 .

[151]  J. R.,et al.  Quantitative analysis , 1892, Nature.