Bile acids and colon cancer: Solving the puzzle with nuclear receptors.

[1]  Hans Clevers,et al.  The cancer stem cell: premises, promises and challenges , 2011, Nature Medicine.

[2]  A. Bhattacharyya,et al.  Carcinogenicity of deoxycholate, a secondary bile acid , 2011, Archives of Toxicology.

[3]  P. Siersema,et al.  Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease , 2011, Gut.

[4]  Elizabeth E. Hoskins,et al.  Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro , 2010, Nature.

[5]  A. Tjønneland,et al.  Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study , 2010, BMJ : British Medical Journal.

[6]  Hans Clevers,et al.  Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells , 2010, Cell.

[7]  R. Lambert,et al.  The dimensions of the CRC problem. , 2010, Best practice & research. Clinical gastroenterology.

[8]  H. Bernstein,et al.  Hydrophobic Bile Acid-Induced Micronuclei Formation, Mitotic Perturbations, and Decreases in Spindle Checkpoint Proteins: Relevance to Genomic Instability in Colon Carcinogenesis , 2010, Nutrition and cancer.

[9]  P. Siersema,et al.  Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. , 2010, Biochimica et biophysica acta.

[10]  S. Zucker,et al.  Sodium taurocholate inhibits intestinal adenoma formation in APCMin/+ mice, potentially through activation of the farnesoid X receptor. , 2010, Carcinogenesis.

[11]  P. Gillberg,et al.  Bile acids: short and long term effects in the intestine , 2010, Scandinavian journal of gastroenterology.

[12]  J. Auwerx,et al.  The intestinal nuclear receptor signature with epithelial localization patterns and expression modulation in tumors. , 2010, Gastroenterology.

[13]  P. Clements,et al.  Intestinal Detoxification Limits the Activation of Hepatic Pregnane X Receptor by Lithocholic Acid , 2010, Drug Metabolism and Disposition.

[14]  Jie Hong,et al.  Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma , 2009, Gut.

[15]  J. Chiang,et al.  Bile acids: regulation of synthesis , 2009, Journal of Lipid Research.

[16]  J. Auwerx,et al.  TGR5-mediated bile acid sensing controls glucose homeostasis. , 2009, Cell metabolism.

[17]  I. Rowland,et al.  Diet, fecal water, and colon cancer--development of a biomarker. , 2009, Nutrition reviews.

[18]  C. Steer,et al.  Bile acids: regulation of apoptosis by ursodeoxycholic acid , 2009, Journal of Lipid Research.

[19]  R. Kanamoto,et al.  Biphasic Regulation of Cell Death and Survival by Hydrophobic Bile Acids in HCT116 Cells , 2009, Nutrition and cancer.

[20]  O. Briz,et al.  Bile-acid-induced cell injury and protection. , 2009, World journal of gastroenterology.

[21]  Huawei Zeng,et al.  Deoxycholic acid and selenium metabolite methylselenol exert common and distinct effects on cell cycle, apoptosis, and MAP kinase pathway in HCT116 human colon cancer cells , 2009, Nutrition and cancer.

[22]  F. Gonzalez,et al.  Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor. , 2009, Biological & pharmaceutical bulletin.

[23]  Ann M. Thomas,et al.  Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development , 2009, Journal of Pharmacology and Experimental Therapeutics.

[24]  S. Anant,et al.  Characterization of Enantiomeric Bile Acid-induced Apoptosis in Colon Cancer Cell Lines* , 2009, Journal of Biological Chemistry.

[25]  Hans Clevers,et al.  Crypt stem cells as the cells-of-origin of intestinal cancer , 2009, Nature.

[26]  A. Moschetta,et al.  Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. , 2008, Cancer research.

[27]  Angelika Amon,et al.  Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells , 2008, Science.

[28]  R. Richardson,et al.  Prominin1 marks intestinal stem cells that are susceptible to neoplastic transformation , 2008, Nature.

[29]  D. Häussinger,et al.  Endocrine and paracrine role of bile acids. , 2008, World journal of gastroenterology.

[30]  D. Mangelsdorf,et al.  Nuclear receptors of the enteric tract: guarding the frontier. , 2008, Nutrition reviews.

[31]  Johan Auwerx,et al.  Targeting bile-acid signalling for metabolic diseases , 2008, Nature Reviews Drug Discovery.

[32]  M. Capecchi,et al.  Bmi1 is expressed in vivo in intestinal stem cells , 2008, Nature Genetics.

[33]  Jie Zhou,et al.  The antiapoptotic role of pregnane X receptor in human colon cancer cells. , 2008, Molecular endocrinology.

[34]  A. Moschetta,et al.  Nuclear receptors, intestinal architecture and colon cancer: an intriguing link , 2008, Cellular and Molecular Life Sciences.

[35]  R. Kanamoto,et al.  Deoxycholic Acid Can Induce Apoptosis in the Human Colon Cancer Cell Line HCT116 in the Absence of Bax , 2007, Nutrition and cancer.

[36]  H. Clevers,et al.  Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.

[37]  J. Steinbach,et al.  Human cecal bile acids: concentration and spectrum. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[38]  J. Ward,et al.  Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. , 2007, Carcinogenesis.

[39]  Hiroshi Yasuda,et al.  Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. , 2007, Biochemical and biophysical research communications.

[40]  Yun Yen,et al.  Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. , 2007, Cancer research.

[41]  A. Clarke Wnt signalling in the mouse intestine , 2006, Oncogene.

[42]  Y. Yoo,et al.  Modulation of the cell cycle and induction of apoptosis in human cancer cells by synthetic bile acids. , 2006, Current cancer drug targets.

[43]  R. Fodde,et al.  APC and Oncogenic KRAS Are Synergistic in Enhancing Wnt Signaling in Intestinal Tumor Formation and Progression , 2006 .

[44]  J. Behrens,et al.  The canonical Wnt signalling pathway and its APC partner in colon cancer development , 2006, Gut.

[45]  Jesse D. Martinez,et al.  Deoxycholic Acid Induces Intracellular Signaling through Membrane Perturbations* , 2006, Journal of Biological Chemistry.

[46]  Ke Ma,et al.  Farnesoid X receptor is essential for normal glucose homeostasis. , 2006, The Journal of clinical investigation.

[47]  S. Kliewer,et al.  Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[48]  J. Auwerx,et al.  Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation , 2006, Nature.

[49]  P. Dawson,et al.  OSTα‐OSTβ: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia , 2005 .

[50]  Hans Clevers,et al.  Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. , 2005, Trends in molecular medicine.

[51]  J. Raufman,et al.  Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors. , 2005, Biochemical pharmacology.

[52]  S. Kliewer,et al.  Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. , 2005, Cell metabolism.

[53]  P. Dawson,et al.  The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter* , 2005, Journal of Biological Chemistry.

[54]  P. Hylemon,et al.  Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature. , 2005, Journal of clinical gastroenterology.

[55]  R. Sinha,et al.  Meat consumption and risk of colorectal cancer. , 2005, JAMA.

[56]  Thomas J. Jones,et al.  Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice , 2005, Hepatology.

[57]  A. de Gottardi,et al.  The Bile Acid Nuclear Receptor FXR and the Bile Acid Binding Protein IBABP Are Differently Expressed in Colon Cancer , 2004, Digestive Diseases and Sciences.

[58]  C. Liddle,et al.  Feed-forward Regulation of Bile Acid Detoxification by CYP3A4 , 2004, Journal of Biological Chemistry.

[59]  A. Hofmann Detoxification of Lithocholic Acid, A Toxic Bile Acid: Relevance to Drug Hepatotoxicity , 2004, Drug metabolism reviews.

[60]  F. Kuipers,et al.  Enterohepatic Circulation of Bile Salts in Farnesoid X Receptor-deficient Mice , 2003, Journal of Biological Chemistry.

[61]  Takao Nakamura,et al.  Identification of membrane-type receptor for bile acids (M-BAR). , 2002, Biochemical and biophysical research communications.

[62]  M. Haussler,et al.  Vitamin D Receptor As an Intestinal Bile Acid Sensor , 2002, Science.

[63]  R. Evans,et al.  Nuclear receptors and lipid physiology: opening the X-files. , 2001, Science.

[64]  R. DuBois,et al.  The molecular basis for prevention of colorectal cancer. , 2001, Clinical colorectal cancer.

[65]  Masahiro Tohkin,et al.  Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis , 2000, Cell.

[66]  B. Neuschwander‐Tetri,et al.  Humanized xenobiotic response in mice expressing nuclear receptor SXR , 2000, Nature.

[67]  Roger A. Davis,et al.  Bile Acid Induction of Cytokine Expression by Macrophages Correlates with Repression of Hepatic Cholesterol 7α-Hydroxylase* , 2000, The Journal of Biological Chemistry.

[68]  J. Lehmann,et al.  Bile acids: natural ligands for an orphan nuclear receptor. , 1999, Science.

[69]  M. Makishima,et al.  Identification of a nuclear receptor for bile acids. , 1999, Science.

[70]  R. Sampliner,et al.  A bile acid-induced apoptosis assay for colon cancer risk and associated quality control studies. , 1999, Cancer research.

[71]  Jasmine Chen,et al.  Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. , 1999, Molecular cell.

[72]  J. Lehmann,et al.  An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway , 1998, Cell.

[73]  K. Kinzler,et al.  Lessons from Hereditary Colorectal Cancer , 1996, Cell.

[74]  F. Nagengast,et al.  Role of bile acids in colorectal carcinogenesis. , 1995, European journal of cancer.

[75]  H. Schneider A factor in the increased risk of colorectal cancer due to ingestion of animal fat is inhibition of colon epithelial cell glutathione S-transferase, an enzyme that detoxifies mutagens. , 1992, Medical hypotheses.

[76]  A. Hofmann The enterohepatic circulation of bile acids in mammals: form and functions. , 2009, Frontiers in bioscience.

[77]  C M Payne,et al.  Deoxycholate induces mitochondrial oxidative stress and activates NF-kappaB through multiple mechanisms in HCT-116 colon epithelial cells. , 2007, Carcinogenesis.

[78]  A. Berg Nutrition, development, and population growth. , 1973, Population bulletin.