Intake estimation of total and individual flavan-3-ols, proanthocyanidins and theaflavins, their food sources and determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Epidemiological studies suggest health-protective effects of flavan-3-ols and their derived compounds on chronic diseases. The present study aimed to estimate dietary flavan-3-ol, proanthocyanidin (PA) and theaflavin intakes, their food sources and potential determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration cohort. Dietary data were collected using a standardised 24 h dietary recall software administered to 36 037 subjects aged 35-74 years. Dietary data were linked with a flavanoid food composition database compiled from the latest US Department of Agriculture and Phenol-Explorer databases and expanded to include recipes, estimations and retention factors. Total flavan-3-ol intake was the highest in UK Health-conscious men (453·6 mg/d) and women of UK General population (377·6 mg/d), while the intake was the lowest in Greece (men: 160·5 mg/d; women: 124·8 mg/d). Monomer intake was the highest in UK General population (men: 213·5 mg/d; women: 178·6 mg/d) and the lowest in Greece (men: 26·6 mg/d in men; women: 20·7 mg/d). Theaflavin intake was the highest in UK General population (men: 29·3 mg/d; women: 25·3 mg/d) and close to zero in Greece and Spain. PA intake was the highest in Asturias (men: 455·2 mg/d) and San Sebastian (women: 253 mg/d), while being the lowest in Greece (men: 134·6 mg/d; women: 101·0 mg/d). Except for the UK, non-citrus fruits (apples/pears) were the highest contributors to the total flavan-3-ol intake. Tea was the main contributor of total flavan-3-ols in the UK. Flavan-3-ol, PA and theaflavin intakes were significantly different among all assessed groups. This study showed heterogeneity in flavan-3-ol, PA and theaflavin intake throughout the EPIC countries.

[1]  F. Clavel-Chapelon,et al.  Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort , 2011, British Journal of Nutrition.

[2]  Augustin Scalbert,et al.  Dietary intake of 337 polyphenols in French adults. , 2011, The American journal of clinical nutrition.

[3]  F. Clavel-Chapelon,et al.  Estimation of the intake of anthocyanidins and their food sources in the European Prospective Investigation into Cancer and Nutrition (EPIC) study , 2011, British Journal of Nutrition.

[4]  O. Chun,et al.  Estimation of daily proanthocyanidin intake and major food sources in the U.S. diet. , 2011, The Journal of nutrition.

[5]  A. Vieira,et al.  An assessment of dietary flavonoid intake in the UK and Ireland , 2011, International journal of food sciences and nutrition.

[6]  B. Bartolomé,et al.  Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites. , 2010, Food & function.

[7]  A. Trichopoulou,et al.  Antioxidant intakes and food sources in Greek adults. , 2010, The Journal of nutrition.

[8]  E. Negri,et al.  Flavonoids, proanthocyanidins, and the risk of stomach cancer , 2010, Cancer Causes & Control.

[9]  J. A. Menéndez,et al.  Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008. , 2010, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[10]  D. Arveiler,et al.  Association between the frequency of fruit and vegetable consumption and cardiovascular disease in male smokers and non-smokers , 2010, European Journal of Clinical Nutrition.

[11]  R. Lamuela-Raventós,et al.  Estimation of dietary sources and flavonoid intake in a Spanish adult population (EPIC-Spain). , 2010, Journal of the American Dietetic Association.

[12]  E. Negri,et al.  Proanthocyanidins and the risk of colorectal cancer in Italy , 2010, Cancer Causes & Control.

[13]  David S. Wishart,et al.  Phenol-Explorer: an online comprehensive database on polyphenol contents in foods , 2010, Database J. Biol. Databases Curation.

[14]  E. Álvarez-Parrilla,et al.  Fruit and Vegetable Phytochemicals , 2009 .

[15]  I. Macdonald,et al.  Functional foods for health promotion: state-of-the-science on dietary flavonoids. Extended abstracts from the 12th Annual Conference on Functional Foods for Health Promotion, April 2009. , 2009, Nutrition reviews.

[16]  J. Shaw,et al.  Deleterious Associations of Sitting Time and Television Viewing Time With Cardiometabolic Risk Biomarkers , 2009, Diabetes Care.

[17]  E. Riboli,et al.  Dietary fat intake in the European Prospective Investigation into Cancer and Nutrition: results from the 24-h dietary recalls , 2009, European Journal of Clinical Nutrition.

[18]  F. Clavel-Chapelon,et al.  Use of dietary supplements in the European Prospective Investigation into Cancer and Nutrition calibration study , 2009, European Journal of Clinical Nutrition.

[19]  J. Little,et al.  Dietary flavonoid intake and colorectal cancer: a case–control study , 2009, British Journal of Nutrition.

[20]  P. Mattila,et al.  Proanthocyanidins in common food products of plant origin. , 2009, Journal of agricultural and food chemistry.

[21]  R. Morishita,et al.  Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases , 2009, Mediators of inflammation.

[22]  Xin Wang,et al.  Cancer prevention by tea: animal studies, molecular mechanisms and human relevance , 2009, Nature Reviews Cancer.

[23]  C. la Vecchia,et al.  Mortality from cardiovascular and cerebrovascular diseases in Europe and other areas of the world: an update , 2009, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[24]  M. Uehara,et al.  Distribution and Major Sources of Flavonoid Intakes in the Middle-Aged Japanese Women , 2009, Journal of clinical biochemistry and nutrition.

[25]  M. Castell,et al.  Cocoa: antioxidant and immunomodulator , 2009, British Journal of Nutrition.

[26]  R. Goldbohm,et al.  Higher dietary flavone, flavonol, and catechin intakes are associated with less of an increase in BMI over time in women: a longitudinal analysis from the Netherlands Cohort Study. , 2008, The American journal of clinical nutrition.

[27]  C. Auger,et al.  Bioavailability of polyphenon E flavan-3-ols in humans with an ileostomy. , 2008, The Journal of nutrition.

[28]  Ian Harvey,et al.  Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. , 2008, The American journal of clinical nutrition.

[29]  G. Williamson,et al.  Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction? , 2008, The British journal of nutrition.

[30]  N. Wareham,et al.  Occupational social class, risk factors and cardiovascular disease incidence in men and women: a prospective study in the European Prospective Investigation of Cancer and Nutrition in Norfolk (EPIC-Norfolk) cohort , 2008, European Journal of Epidemiology.

[31]  H. Morgenstern,et al.  Dietary flavonoid intake and lung cancer—A population‐based case‐control study , 2008, Cancer.

[32]  D. Albanes,et al.  Flavonoid Intake and Risk of Pancreatic Cancer in Male Smokers (Finland) , 2008, Cancer Epidemiology Biomarkers & Prevention.

[33]  J. Kennedy,et al.  Compositional investigation of phenolic polymers isolated from Vitis vinifera L. Cv. Pinot Noir during fermentation. , 2007, Journal of agricultural and food chemistry.

[34]  O. Chun,et al.  Estimated dietary flavonoid intake and major food sources of U.S. adults. , 2007, The Journal of nutrition.

[35]  D. Barrett,et al.  Review Nutritional comparison of fresh, frozen and canned fruits and vegetables. Part 1. Vitamins C and B and phenolic compounds , 2007 .

[36]  S. Somerset,et al.  Age-related variations in flavonoid intake and sources in the Australian population , 2006, Public Health Nutrition.

[37]  N. Hollenberg,et al.  (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[38]  D. Heber,et al.  Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement. , 2004, The American journal of clinical nutrition.

[39]  S. Apers,et al.  Proanthocyanidins in health care: current and new trends. , 2004, Current medicinal chemistry.

[40]  C. Auger,et al.  Catechins and procyanidins in Mediterranean diets , 2004 .

[41]  G. Beecher,et al.  Concentrations of proanthocyanidins in common foods and estimations of normal consumption. , 2004, The Journal of nutrition.

[42]  N. Day,et al.  Television viewing and low participation in vigorous recreation are independently associated with obesity and markers of cardiovascular disease risk: EPIC-Norfolk population-based study , 2003, European Journal of Clinical Nutrition.

[43]  A. Miller,et al.  Consumption of vegetables, fruit and other plant foods in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts from 10 European countries , 2002, Public Health Nutrition.

[44]  N E Day,et al.  European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection , 2002, Public Health Nutrition.

[45]  F. Clavel-Chapelon,et al.  European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study: rationale, design and population characteristics , 2002, Public Health Nutrition.

[46]  F. Clavel-Chapelon,et al.  Physical activity of subjects aged 50–64 years involved in the European Prospective Investigation into Cancer and Nutrition (EPIC) , 2002, Public Health Nutrition.

[47]  M. Schulze,et al.  Diversity of dietary patterns observed in the European Prospective Investigation into Cancer and Nutrition (EPIC) project , 2002, Public Health Nutrition.

[48]  A. Miller,et al.  Overweight, obesity and fat distribution in 50- to 64-year-old participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) , 2002, Public Health Nutrition.

[49]  C. Rice-Evans,et al.  Black Tea Represents a Major Source of Dietary Phenolics Among Regular Tea Drinkers , 2002, Free radical research.

[50]  D. Kromhout,et al.  Catechin intake might explain the inverse relation between tea consumption and ischemic heart disease: the Zutphen Elderly Study. , 2001, The American journal of clinical nutrition.

[51]  E. Riboli,et al.  Standardization of the 24-hour diet recall calibration method used in the European Prospective Investigation into Cancer and Nutrition (EPIC): general concepts and preliminary results , 2000, European Journal of Clinical Nutrition.

[52]  Celestino Santos-Buelga,et al.  Proanthocyanidins and tannin‐like compounds – nature, occurrence, dietary intake and effects on nutrition and health , 2000 .

[53]  I. Arts,et al.  Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods. , 2000, Journal of agricultural and food chemistry.

[54]  N Slimani,et al.  Structure of the standardized computerized 24-h diet recall interview used as reference method in the 22 centers participating in the EPIC project. European Prospective Investigation into Cancer and Nutrition. , 1999, Computer methods and programs in biomedicine.

[55]  Alan Crozier,et al.  Quantitative analysis of the flavonoid content of commercial tomatoes , 1997 .

[56]  E Riboli,et al.  Calibration of dietary intake measurements in prospective cohort studies. , 1995, American journal of epidemiology.

[57]  P. Mattila,et al.  Nutrient Requirements and Optimal Nutrition Dietary Intake and Major Food Sources of Polyphenols in Finnish Adults 1 – 3 , 2008 .

[58]  D. Barrett,et al.  Nutritional comparison of fresh, frozen and canned fruits and vegetables. Part 1. Vitamins C and B and phenolic compounds , 2007 .

[59]  Ramesh Vidavalur,et al.  Significance of wine and resveratrol in cardiovascular disease: French paradox revisited. , 2006, Experimental and clinical cardiology.

[60]  Gary Williamson,et al.  Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. , 2005, The American journal of clinical nutrition.

[61]  Gary Williamson,et al.  Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. , 2005, The American journal of clinical nutrition.

[62]  N. Slimani,et al.  Comparison of telephone vs face-to-face interviews in the assessment of dietary intake by the 24 h recall EPIC SOFT program—the Norwegian calibration study , 2003, European Journal of Clinical Nutrition.

[63]  A. Kruizinga,et al.  Socio-economic status, dietary intake and 10 y trends: the Dutch National Food Consumption Survey , 2003, European Journal of Clinical Nutrition.

[64]  E Riboli,et al.  Validation and calibration of dietary intake measurements in the EPIC project: methodological considerations. European Prospective Investigation into Cancer and Nutrition. , 1997, International journal of epidemiology.

[65]  E Riboli,et al.  Adjustment for bias due to errors in exposure assessments in multicenter cohort studies on diet and cancer: a calibration approach. , 1994, The American journal of clinical nutrition.

[66]  S. Erzinçlioǧlu,et al.  A comparison of the diets of non-smokers and smokers. , 1991, British journal of addiction.