Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast

In Saccharomyces cerevisiae, the primary septum (PS), a functional equivalent of animal ECM, is synthesized during cytokinesis by the chitin synthase Chs2. The mitotic exit kinase Dbf2 regulates PS formation by direct phosphorylation of Chs2, which triggers its dissociation from the actomyosin ring during the late stage of cytokinesis.

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