Interface dynamics in a two-phase tumor growth model

We study a tumor growth model in two space dimensions, where proliferation of the tumor cells leads to expansion of the tumor domain and migration of surrounding normal tissues into the exterior vacuum. The model features two moving interfaces separating the tumor, the normal tissue, and the exterior vacuum. We prove local-in-time existence and uniqueness of strong solutions for their evolution starting from a nearly radial initial configuration. It is assumed that the tumor has lower mobility than the normal tissue, which is in line with the well-known Saffman-Taylor condition in viscous fingering.

[1]  J. Vázquez,et al.  Lipschitz Continuity o f Solutions and Interfaces of the N-Dimensional Porous Medium Equation , 1985 .

[2]  S. Shkoller,et al.  Global existence and decay for solutions of the Hele-Shaw flow with injection , 2012, 1208.6213.

[3]  J. Vázquez The Porous Medium Equation: Mathematical Theory , 2006 .

[4]  C. M. Elliott,et al.  A variational inequality approach to Hele-Shaw flow with a moving boundary , 1981, Proceedings of the Royal Society of Edinburgh: Section A Mathematics.

[5]  M E Gurtin,et al.  On interacting populations that disperse to avoid crowding: preservation of segregation , 1985, Journal of mathematical biology.

[6]  R. Caflisch,et al.  Global existence, singular solutions, and ill‐posedness for the Muskat problem , 2004 .

[7]  D. Córdoba,et al.  Contour Dynamics of Incompressible 3-D Fluids in a Porous Medium with Different Densities , 2007 .

[8]  L. Caffarelli,et al.  C1,α regularity of the free boundary for the N-dimensional porous media equation , 1990 .

[9]  M. Muskat Two Fluid Systems in Porous Media. The Encroachment of Water into an Oil Sand , 1934 .

[10]  D. Ambrose Well-posedness of two-phase Hele–Shaw flow without surface tension , 2004, European Journal of Applied Mathematics.

[11]  Robert M. Strain,et al.  On the Muskat problem: Global in time results in 2D and 3D , 2013, 1310.0953.

[12]  B. Perthame,et al.  On interfaces between cell populations with different mobilities , 2016 .

[13]  Enrique Zuazua,et al.  Local regularity for fractional heat equations , 2017, 1704.07562.

[14]  G. Taylor,et al.  The penetration of a fluid into a porous medium or Hele-Shaw cell containing a more viscous liquid , 1958, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.

[15]  Sam Howison,et al.  Complex variable methods in Hele–Shaw moving boundary problems , 1992, European Journal of Applied Mathematics.

[16]  Robert M. Strain,et al.  On the global existence for the Muskat problem , 2010, 1007.3744.

[17]  Inwon C. Kim Uniqueness and Existence Results on the Hele-Shaw and the Stefan Problems , 2003 .

[18]  A. Córdoba,et al.  Interface evolution: the Hele-Shaw and Muskat problems , 2008, 0806.2258.

[19]  M. Vogelius,et al.  Gradient Estimates for Solutions to Divergence Form Elliptic Equations with Discontinuous Coefficients , 2000 .

[20]  A generalized Rayleigh?Taylor condition for the Muskat problem , 2010, 1005.2511.

[21]  Inwon Kim,et al.  Porous Medium Equation with a Drift: Free Boundary Regularity , 2018, Archive for Rational Mechanics and Analysis.

[22]  Omar Lazar,et al.  Global well-posedness for the 2D stable Muskat problem in $H^{3/2}$ , 2018, Annales scientifiques de l'École Normale Supérieure.

[23]  Filippo Santambrogio,et al.  Splitting Schemes and Segregation in Reaction Cross-Diffusion Systems , 2017, SIAM J. Math. Anal..

[24]  M. SIAMJ.,et al.  CLASSICAL SOLUTIONS OF MULTIDIMENSIONAL HELE – SHAW MODELS , 1997 .

[25]  Antonio Córdoba,et al.  Porous media: The Muskat problem in three dimensions , 2013 .

[26]  J. Bear Dynamics of Fluids in Porous Media , 1975 .

[27]  S. Shkoller,et al.  Well-posedness of the Muskat problem with H2 initial data , 2014, 1412.7737.

[28]  Inwon C. Kim,et al.  On nonlinear cross-diffusion systems: an optimal transport approach , 2017, 1705.02457.

[29]  Piotr Gwiazda,et al.  A two-species hyperbolic–parabolic model of tissue growth , 2018, Communications in Partial Differential Equations.

[30]  Avner Friedman,et al.  The ill-posed Hele-Shaw model and the Stefan problem for supercooled water , 1984 .

[31]  M. Chaplain,et al.  Modelling the role of cell-cell adhesion in the growth and development of carcinomas , 1996 .

[32]  B. Matioc Well-Posedness and Stability Results for Some Periodic Muskat Problems , 2018, Journal of Mathematical Fluid Mechanics.

[33]  Avner Friedman,et al.  Regularity of the free boundary of a gas flow in an n-dimensional porous medium. , 1980 .

[34]  D. Lamberton,et al.  Equations d'évolution linéaires associées à des semi-groupes de contractions dans les espaces LP , 1987 .

[35]  Masayasu Mimura,et al.  A free boundary problem arising in a simplified tumour growth model of contact inhibition , 2010 .

[36]  Robert M. Strain,et al.  On the Muskat problem with viscosity jump: Global in time results , 2017, Advances in Mathematics.

[37]  S. Richardson,et al.  Hele Shaw flows with a free boundary produced by the injection of fluid into a narrow channel , 1972, Journal of Fluid Mechanics.

[38]  B. Perthame,et al.  Hele–Shaw Limit for a System of Two Reaction-(Cross-)Diffusion Equations for Living Tissues , 2019, Archive for Rational Mechanics and Analysis.

[39]  P. Bassanini,et al.  Elliptic Partial Differential Equations of Second Order , 1997 .