Pharmacological significance of glycosylation in therapeutic proteins.
暂无分享,去创建一个
[1] T. Gerngross,et al. Glycosylation engineering in yeast: the advent of fully humanized yeast. , 2007, Current opinion in biotechnology.
[2] K. Shitara,et al. The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity* , 2003, The Journal of Biological Chemistry.
[3] R. Kunert,et al. A plant-derived human monoclonal antibody induces an anti-carbohydrate immune response in rabbits. , 2007, Glycobiology.
[4] Shigeru Iida,et al. Establishment of FUT8 knockout Chinese hamster ovary cells: An ideal host cell line for producing completely defucosylated antibodies with enhanced antibody‐dependent cellular cytotoxicity , 2004, Biotechnology and bioengineering.
[5] B. van den Hazel,et al. Glycosylation of an N-terminal extension prolongs the half-life and increases the in vivo activity of follicle stimulating hormone. , 2003, The Journal of clinical endocrinology and metabolism.
[6] Youwei Jiang,et al. Optimization of humanized IgGs in glycoengineered Pichia pastoris , 2006, Nature Biotechnology.
[7] D. C. Linch,et al. Development of antibodies to unprotected glycosylation sites on recombinant human GM-CSF , 1990, The Lancet.
[8] S. Withers,et al. Designer enzymes for glycosphingolipid synthesis by directed evolution. , 2009, Nature chemical biology.
[9] Teresa Mitchell,et al. Engineering of an artificial glycosylation pathway blocked in core oligosaccharide assembly in the yeast Pichia pastoris: production of complex humanized glycoproteins with terminal galactose. , 2004, Glycobiology.
[10] P. Parren,et al. Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells. , 2008, Blood.
[11] S. Müller,et al. Recombinant MUC1 Probe Authentically Reflects Cell-specific O-Glycosylation Profiles of Endogenous Breast Cancer Mucin , 2002, The Journal of Biological Chemistry.
[12] R. Dwek,et al. Glycosylation and the immune system. , 2001, Science.
[13] S. Elliott,et al. Control of rHuEPO biological activity: the role of carbohydrate. , 2004, Experimental hematology.
[14] Y. Chiba,et al. Glycan engineering and production of 'humanized' glycoprotein in yeast cells. , 2009, Biological & pharmaceutical bulletin.
[15] J. Davies,et al. Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FC gamma RIII. , 2001, Biotechnology and bioengineering.
[16] J. Mermod,et al. Site-specific O-glycosylation of human granulocyte/macrophage colony-stimulating factor secreted by yeast and animal cells. , 1992, European journal of biochemistry.
[17] J. Lustbader,et al. Effects of long-acting recombinant human follicle-stimulating hormone analogs containing N-linked glycosylation on murine folliculogenesis. , 2005, Fertility and sterility.
[18] Scott Estes,et al. Development of a simple and rapid method for producing non‐fucosylated oligomannose containing antibodies with increased effector function , 2008, Biotechnology and bioengineering.
[19] S. Iida,et al. Nonfucosylated rituximab potentiates human neutrophil phagocytosis through its high binding for FcgammaRIIIb and MHC class II expression on the phagocytotic neutrophils. , 2009, Experimental hematology.
[20] R. Horstkorte,et al. Increasing the sialylation of therapeutic glycoproteins: the potential of the sialic acid biosynthetic pathway. , 2009, Journal of pharmaceutical sciences.
[21] Quynh-Thu Le,et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. , 2008, The New England journal of medicine.
[22] J. Taylor‐Papadimitriou,et al. The ST6GalNAc-I Sialyltransferase Localizes throughout the Golgi and Is Responsible for the Synthesis of the Tumor-associated Sialyl-Tn O-Glycan in Human Breast Cancer* , 2006, Journal of Biological Chemistry.
[23] A. Hsueh,et al. Enhanced stimulation of follicle maturation and ovulatory potential by long acting follicle-stimulating hormone agonists with extended carboxyl-terminal peptides. , 1992, Endocrinology.
[24] T. Wurch,et al. Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins. , 2008, Current pharmaceutical biotechnology.
[25] H. Kozutsumi,et al. Relationship between sugar chain structure and biological activity of recombinant human erythropoietin produced in Chinese hamster ovary cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[26] L. Presta,et al. Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity* , 2002, The Journal of Biological Chemistry.
[27] M. Takeuchi,et al. Role of antennary structure of N-linked sugar chains in renal handling of recombinant human erythropoietin. , 1995, Blood.
[28] A. Helenius,et al. Intracellular functions of N-linked glycans. , 2001, Science.
[29] Roy Jefferis,et al. Glycosylation as a strategy to improve antibody-based therapeutics , 2009, Nature Reviews Drug Discovery.
[30] Stacey Ma,et al. Characterization of a complex glycoprotein whose variable metabolic clearance in humans is dependent on terminal N-acetylglucosamine content. , 2008, Biologicals : journal of the International Association of Biological Standardization.
[31] Lihua Huang,et al. Impact of variable domain glycosylation on antibody clearance: an LC/MS characterization. , 2006, Analytical biochemistry.
[32] R. Kontermann,et al. N-Glycosylation as Novel Strategy to Improve Pharmacokinetic Properties of Bispecific Single-chain Diabodies* , 2008, Journal of Biological Chemistry.
[33] S. Elliott,et al. Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins. , 2005, Journal of pharmaceutical sciences.
[34] M. Butler,et al. Optimisation of the Cellular Metabolism of Glycosylation for Recombinant Proteins Produced by Mammalian Cell Systems , 2006, Cytotechnology.
[35] Susan C. Brown,et al. Defective glycosylation in muscular dystrophy , 2002, The Lancet.
[36] James E. Bailey,et al. Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity , 1999, Nature Biotechnology.
[37] Jack Hoopes,et al. Humanization of Yeast to Produce Complex Terminally Sialylated Glycoproteins , 2006, Science.
[38] D. Danilenko,et al. Evidence for an Asialoglycoprotein Receptor on Nonparenchymal Cells for O-Linked Glycoproteins , 2008, Journal of Pharmacology and Experimental Therapeutics.
[39] S. Iida,et al. The N-linked oligosaccharide at FcγRIIIa Asn-45: an inhibitory element for high FcγRIIIa binding affinity to IgG glycoforms lacking core fucosylation , 2008, Glycobiology.
[40] Z. Li,et al. Optimal and consistent protein glycosylation in mammalian cell culture. , 2009, Glycobiology.
[41] P. Lerouge,et al. Immunoreactivity in mammals of two typical plant glyco-epitopes, core alpha(1,3)-fucose and core xylose. , 2003, Glycobiology.
[42] M. J. Bailey,et al. Identification and quantification of N-linked oligosaccharides released from glycoproteins: an inter-laboratory study. , 2008, Glycobiology.
[43] A. Hsueh,et al. Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin beta subunit to the follitropin beta subunit. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[44] S. Withers,et al. Emerging methods for the production of homogeneous human glycoproteins. , 2009, Nature chemical biology.
[45] R. Ogden,et al. Development and characterization of a long-acting recombinant hFSH agonist. , 2003, Human reproduction.
[46] P. Devroey,et al. Induction of multiple follicular development by a single dose of long-acting recombinant follicle-Stimulating hormone (FSH-CTP, corifollitropin alfa) for controlled ovarian stimulation before in vitro fertilization. , 2004, The Journal of clinical endocrinology and metabolism.
[47] Teresa Mitchell,et al. Production of Complex Human Glycoproteins in Yeast , 2003, Science.
[48] T. Endo. O-mannosyl glycans in mammals. , 1999, Biochimica et biophysica acta.
[49] L. Gardner,et al. Leukocyte extravasation: chemokine transport and presentation by the endothelium. , 2002, Blood.
[50] Teresa Mitchell,et al. Production of monoclonal antibodies by glycoengineered Pichia pastoris. , 2009, Journal of biotechnology.
[51] Leonard G Presta,et al. Molecular engineering and design of therapeutic antibodies. , 2008, Current opinion in immunology.
[52] A. Herscovics. Processing glycosidases of Saccharomyces cerevisiae. , 1999, Biochimica et biophysica acta.
[53] Byung-Kwon Choi,et al. Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[54] R. Jefferis,et al. Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action. , 2009, Trends in pharmacological sciences.
[55] K. Campbell,et al. Dystroglycan: from biosynthesis to pathogenesis of human disease , 2006, Journal of Cell Science.
[56] J. Baenziger,et al. Pituitary glycoprotein hormone oligosaccharides: structure, synthesis and function of the asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin. , 1988, Biochimica et biophysica acta.
[57] M. Rogge,et al. Immunomodulation by LFA3TIP, an LFA-3/IgG1 fusion protein: cell line dependent glycosylation effects on pharmacokinetics and pharmacodynamic markers. , 1995, Therapeutic immunology.
[58] R. Ogden,et al. Long-acting follicle-stimulating hormone analogs containing N-linked glycosylation exhibited increased bioactivity compared with o-linked analogs in female rats. , 2004, The Journal of clinical endocrinology and metabolism.
[59] L. Lehle,et al. The oligosaccharyltransferase complex from yeast. , 1999, Biochimica et biophysica acta.
[60] S. Kornfeld,et al. Assembly of asparagine-linked oligosaccharides. , 1985, Annual review of biochemistry.
[61] A. Woods,et al. The role of syndecans in disease and wound healing. , 2006, Matrix biology : journal of the International Society for Matrix Biology.
[62] Terrance A Stadheim,et al. Challenges in therapeutic glycoprotein production. , 2006, Current opinion in biotechnology.
[63] J. M. Beals,et al. Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions. , 2002, Biochemistry.
[64] D. Casley,et al. O-glycosylation delays the clearance of human IGF-binding protein-6 from the circulation. , 2000, European journal of endocrinology.
[65] T. Gerngross,et al. Advances in the production of human therapeutic proteins in yeasts and filamentous fungi , 2004, Nature Biotechnology.
[66] S. Wildt,et al. The humanization of N-glycosylation pathways in yeast , 2005, Nature Reviews Microbiology.
[67] M. Aebi,et al. The dolichol pathway of N-linked glycosylation. , 1999, Biochimica et biophysica acta.