T-cell antigen deficiencies and clonal rearrangements of T-cell receptor genes in pagetoid reticulosis (Woringer-Kolopp disease).

PAGETOID reticulosis (Woringer-Kolopp disease) is a rare skin disorder consisting of solitary or localized, often hyperkeratotic, cutaneous plaques. Histologically, the involved areas of skin show a prominent infiltrate of cytologically atypical mononuclear cells within a hyperplastic epidermis.1 , 2 Clinically, these lesions are indolent. There have been reports that the condition has resolved in several patients after local surgery or radiation therapy; however, other patients have presented with a disseminated form of pagetoid reticulosis, the Ketron-Goodman variant.2 , 3 Some of these patients have also had typical lesions of mycosis fungoides, a form of cutaneous T-cell lymphoma, and have died.4 5 6 The nature of the . . .

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