Monte-Carlo simulation of photon trans-illumination time of flight

We present a Monte Carlo (MC) program for determining the temporal behavior of radiation in turbid media, in general, and a tissue, in particular. An object-oriented MC program with flexibility for parallel implementation, and for performing stochastic analysis, is described. We determine the temporal probability distribution functions for three tissues: I ) a lipid-based tissue phantom, II ) a healthy dental tissue, and III ) a dental tissue with caries. The expected time of flight for transmitted radiation is calculated. Signal-to-noise ratios (SNR) are then obtained for several temporal thresholds. By restraining the time threshold, a two orders of magnitude increase in SNR is predicted. A multivariate analysis is finally proposed to complement the discrimination process, necessary for trans-illumination interferometry.

[1]  Paulino Vacas-Jacques,et al.  Reduced coherence and calibration optimization for transillumination interferometry , 2007, SPIE BiOS.

[2]  Marija Strojnik,et al.  Numerical modeling of tooth response to laser pulse irradiation , 2006, SPIE Optics + Photonics.

[3]  R. Giovanelli.  Reflection by Semi-infinite Diffusers , 1955 .

[4]  Marija Strojnik,et al.  Interferometric Tissue Characterization: I: Theory , 2005, SPIE Optics + Photonics.

[5]  Takuji Nishimura,et al.  Mersenne twister: a 623-dimensionally equidistributed uniform pseudo-random number generator , 1998, TOMC.

[6]  B. Pogue,et al.  Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry. , 2006, Journal of biomedical optics.

[7]  Rafael Yuste,et al.  Fluorescence microscopy today , 2005, Nature Methods.

[8]  Marija Strojnik,et al.  Interferometric tissue characterization: III: calibration , 2005, SPIE Optics + Photonics.

[9]  Daniel Fried,et al.  Attenuation of 1310- and 1550-nm laser light through sound dental enamel , 2002, SPIE BiOS.

[10]  Ashleyj . Welch,et al.  Optical-Thermal Response of Laser-Irradiated Tissue , 1995 .

[11]  H. J. van Staveren,et al.  Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm. , 1991, Applied optics.

[12]  S. Yun,et al.  Phase-resolved optical frequency domain imaging. , 2005, Optics express.

[13]  J. J. Bosch,et al.  Theoretical model for the scattering of light by dentin and comparison with measurements. , 1993, Applied optics.

[14]  Sang Joon Kim,et al.  A Mathematical Theory of Communication , 2006 .

[15]  Daniel Fried,et al.  Near-infrared transillumination at 1310-nm for the imaging of early dental decay. , 2003, Optics express.

[16]  Sergio Fantini,et al.  Spatial and Spectral Information in Optical Mammography , 2005, Technology in cancer research & treatment.

[17]  Aaron D. Wyner,et al.  Claude Elwood Shannon: Collected Papers , 1993 .

[18]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[19]  Marija Strojnik,et al.  Interferometric Tissue Characterization: II. Experimental , 2005, SPIE Optics + Photonics.

[20]  Nathan C Shaner,et al.  A guide to choosing fluorescent proteins , 2005, Nature Methods.

[21]  Marija Strojnik,et al.  Interferometric Tissue Characterization: IV: Material coherence function , 2005, SPIE Optics + Photonics.

[22]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[23]  S. Prahl.  The Adding-Doubling Method , 1995 .

[24]  J. Featherstone,et al.  Nature of light scattering in dental enamel and dentin at visible and near-infrared wavelengths. , 1995, Applied optics.

[25]  Paulino Vacas-Jacques,et al.  Transmission profile function reconstruction for complex transmission interferometry: biomedical applications , 2006, SPIE Optics + Photonics.