The Vanilloid Receptor TRPV1 Is Tonically Activated In Vivo and Involved in Body Temperature Regulation
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J. Treanor | T. Juan | J. Louis | A. Bannon | N. Gavva | S. Surapaneni | M. Norman | E. Magal | S. Lehto | L. Klionsky | A. Gore | Bora Han | H. Deng | Rongzhen Kuang | Jue Wang | D. Hovland | R. Tamir | B. Youngblood | A. Le | D. Zhu | M. H. Norman
[1] A. A. Romanovsky,et al. CALL FOR PAPERS Physiology and Pharmacology of Temperature Regulation Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system , 2007 .
[2] A. Patapoutian,et al. Trp ion channels and temperature sensation. , 2006, Annual review of neuroscience.
[3] J. Treanor,et al. Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles. , 2006, Journal of medicinal chemistry.
[4] J. Treanor,et al. Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists. , 2005, Bioorganic & medicinal chemistry letters.
[5] J. Treanor,et al. Proton Activation Does Not Alter Antagonist Interaction with the Capsaicin-Binding Pocket of TRPV1 , 2005, Molecular Pharmacology.
[6] E. Pintér,et al. Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation. , 2005, Arthritis and rheumatism.
[7] K. Bölcskei,et al. Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat. , 2005, European journal of pharmacology.
[8] A. Gomtsyan,et al. A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel Transient Receptor Potential Type V1 Receptor Antagonist, Relieves Pathophysiological Pain Associated with Inflammation and Tissue Injury in Rats , 2005, Journal of Pharmacology and Experimental Therapeutics.
[9] A. Gomtsyan,et al. A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel and Selective Transient Receptor Potential Type V1 Receptor Antagonist, Blocks Channel Activation by Vanilloids, Heat, and Acid , 2005, Journal of Pharmacology and Experimental Therapeutics.
[10] L. Csiba,et al. Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain. , 2005, Brain research. Molecular brain research.
[11] M. Caterina,et al. Attenuated fever response in mice lacking TRPV1 , 2005, Neuroscience Letters.
[12] Mark H. Norman,et al. AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a Novel Vanilloid Receptor 1 (TRPV1) Antagonist with Antihyperalgesic Properties , 2005, Journal of Pharmacology and Experimental Therapeutics.
[13] N. Carruthers,et al. Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. , 2005, Journal of medicinal chemistry.
[14] N. Carruthers,et al. Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain , 2005, The Journal of Neuroscience.
[15] A. Moqrich,et al. Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin , 2005, Science.
[16] M. Caterina,et al. Altered Thermal Selection Behavior in Mice Lacking Transient Receptor Potential Vanilloid 4 , 2005, The Journal of Neuroscience.
[17] N. Chen,et al. Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides. , 2005, Journal of medicinal chemistry.
[18] J. Treanor,et al. dioxin-6-yl ) acrylamide ] , a Novel Vanilloid Receptor 1 ( TRPV 1 ) Antagonist with Antihyperalgesic Properties , 2005 .
[19] A. Gomtsyan,et al. a Novel Transient Receptor Potential Type V 1 Receptor Antagonist , Relieves Pathophysiological Pain Associated with Inflammation and Tissue Injury in Rats , 2005 .
[20] J. Szolcsányi. Forty years in capsaicin research for sensory pharmacology and physiology , 2004, Neuropeptides.
[21] P. Holzer. TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia. , 2004, European journal of pharmacology.
[22] Attila Toth,et al. Molecular Determinants of Vanilloid Sensitivity in TRPV1* , 2004, Journal of Biological Chemistry.
[23] A. Szallasi,et al. Vanilloid receptor TRPV1 antagonists as the next generation of painkillers. Are we putting the cart before the horse? , 2004, Journal of medicinal chemistry.
[24] John B Davis,et al. Daily body temperature rhythm and heat tolerance in TRPV1 knockout and capsaicin pretreated mice , 2004, The European journal of neuroscience.
[25] Richard E Middleton,et al. Resiniferatoxin binds to the capsaicin receptor (TRPV1) near the extracellular side of the S4 transmembrane domain. , 2004, Biochemistry.
[26] M. van der Stelt,et al. Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. , 2004, European journal of biochemistry.
[27] Jin Kwan Kim,et al. Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects. , 2003, Bioorganic & medicinal chemistry letters.
[28] David E. Clapham,et al. TRP channels as cellular sensors , 2003, Nature.
[29] P. Blumberg,et al. High-affinity partial agonists of the vanilloid receptor. , 2003, Molecular pharmacology.
[30] D. McKemy,et al. Lessons from peppers and peppermint: the molecular logic of thermosensation , 2003, Current Opinion in Neurobiology.
[31] J. Pomonis,et al. N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: II. In Vivo Characterization in Rat Models of Inflammatory and Neuropathic Pain , 2003, Journal of Pharmacology and Experimental Therapeutics.
[32] A. Patapoutian,et al. ThermoTRP channels and beyond: mechanisms of temperature sensation , 2003, Nature Reviews Neuroscience.
[33] Qun Sun,et al. N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: I. In Vitro Characterization and Pharmacokinetic Properties , 2003, Journal of Pharmacology and Experimental Therapeutics.
[34] S. Teague,et al. Functional Properties of the High-Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist (4-Hydroxy-5-iodo-3-methoxyphenylacetate ester) Iodo-Resiniferatoxin , 2002, Journal of Pharmacology and Experimental Therapeutics.
[35] C. Woolf,et al. p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia , 2002, Neuron.
[36] David Julius,et al. Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers , 2002, Cell.
[37] A. Basbaum,et al. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition , 2001, Nature.
[38] L. Premkumar,et al. Induction of vanilloid receptor channel activity by protein kinase C , 2000, Nature.
[39] S. Bingham,et al. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia , 2000, Nature.
[40] A I Basbaum,et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. , 2000, Science.
[41] P. Blumberg,et al. Vanilloid (Capsaicin) receptors and mechanisms. , 1999, Pharmacological reviews.
[42] A. Basbaum,et al. The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli , 1998, Neuron.
[43] D. Julius,et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway , 1997, Nature.
[44] M. Palkovits,et al. Specific binding of [3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus membrane preparations. , 1996, Life sciences.
[45] P. Holzer. Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. , 1991, Pharmacological reviews.
[46] A. Asami,et al. Responses of anterior hypothalamic-preoptic thermosensitive neurons to locally applied capsaicin , 1988, Neuropharmacology.
[47] T. Yaksh,et al. Action of intrathecal capsaicin and its structural analogues on the content and release of spinal substance P: Selectivity of action and relationship to analgesia , 1984, Brain Research.
[48] T. Hori. Capsaicin and central control of thermoregulation. , 1984, Pharmacology & therapeutics.
[49] Boulant Ja. Hypothalamic mechanisms in thermoregulation. , 1981 .
[50] J. Boulant. Hypothalamic mechanisms in thermoregulation. , 1981, Federation proceedings.
[51] T. Burks,et al. Neurophysiological and thermoregulatory effects of capsaicin , 1980, Brain Research Bulletin.
[52] A. Jancsó-Gábor,et al. Mitochondrial Changes in Preoptic Neurones after Capsaicin Desensitization of the Hypothalamic Thermodetectors in Rats , 1971, Nature.
[53] N. Jancsó,et al. Stimulation and desensitization of the hypothalamic heat‐sensitive structures by capsaicin in rats , 1970, The Journal of physiology.
[54] J. Szolcsányi,et al. Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea‐pigs , 1970, The Journal of physiology.