Partial bladder outlet obstruction reduces the tissue antioxidant capacity and muscle nerve density of the guinea pig bladder

Reactive nitrogen and oxygen species (RNOS) likely play a role in the development of bladder dysfunction related to bladder outlet obstruction. Antioxidants protect against these free radicals. The aim of our study was to investigate the effect of bladder outlet obstruction on the endogenous antioxidant status of the bladder and to correlate this to bladder structure and function.

[1]  R. Levin,et al.  Novel biomarkers of bladder decompensation after partial bladder obstruction , 2007, Neurourology and urodynamics.

[2]  Barry Halliwell,et al.  Oxidative stress and neurodegeneration: where are we now? , 2006, Journal of neurochemistry.

[3]  D. Grignon,et al.  Prostate cancer: indicators of aggressiveness. , 1997, European urology.

[4]  Alex T L Lin,et al.  Detrusor mitochondrial lipid peroxidation and superoxide dismutase activity in partial bladder outlet obstruction of rabbits , 2005, Neurourology and urodynamics.

[5]  J. Vente,et al.  Alterations to network of NO/cGMP-responsive interstitial cells induced by outlet obstruction in guinea-pig bladder , 2007, Cell and Tissue Research.

[6]  R. Levin,et al.  Effect of partial bladder outlet obstruction on nitrotyrosine levels and their correlation with contractile function , 2006, Neurourology and urodynamics.

[7]  A. Brading,et al.  The effect of bladder outlet obstruction on tissue oxygen tension and blood flow in the pig bladder , 2000, BJU international.

[8]  R. Levin,et al.  Effect of oral Kohki tea on bladder dysfunction induced by severe partial outlet obstruction. , 2002, The Journal of urology.

[9]  J. de Vente,et al.  Interstitial cells and cholinergic signalling in the outer muscle layers of the guinea‐pig bladder , 2006, BJU international.

[10]  J. de Vente,et al.  Damage to the bladder neck alters autonomous activity and its sensitivity to cholinergic agonists , 2007, BJU international.

[11]  A. Wein,et al.  The functional effect of mild outlet obstruction on the rabbit urinary bladder. , 1988, The Journal of urology.

[12]  T. Wilt,et al.  Pygeum africanum for benign prostatic hyperplasia. , 1998, The Cochrane database of systematic reviews.

[13]  R. Levin,et al.  Reperfusion injury of the rat bladder is worse than ischemia. , 2003, The Journal of urology.

[14]  G. V. van Koeveringe,et al.  Lipid peroxidation product 4-hydroxynonenal contributes to bladder smooth muscle damage. , 2008, Urology.

[15]  P. van Kerrebroeck,et al.  Oxidative stress reduces the muscarinic receptor function in the urinary bladder , 2007, Neurourology and urodynamics.

[16]  O. Griffith,et al.  Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. , 1980, Analytical biochemistry.

[17]  A. Brading.  A myogenic basis for the overactive bladder. , 1997, Urology.

[18]  R. Levin,et al.  Protective effect of vitamin E on the response of the rabbit bladder to partial outlet obstruction. , 2001, The Journal of urology.

[19]  Arnold Johnson,et al.  L-NAME, a nitric oxide synthase inhibitor, diminishes oxidative damage in urinary bladder partial outlet obstruction. , 2006, American journal of physiology. Renal physiology.

[20]  A. Bast,et al.  Determination of the antioxidant capacity in blood , 2005, Clinical chemistry and laboratory medicine.

[21]  O. Lux,et al.  Improved HPLC Method for the Simultaneous Measurement of Allantoin and Uric Acid in Plasma , 1992, Annals of clinical biochemistry.

[22]  R. Levin,et al.  Effect of partial outlet obstruction on the myogenic response to field stimulation. , 1998, General pharmacology.

[23]  L. Denis,et al.  A critical review of the pharmacology of the plant extract of Pygeum africanum in the treatment of LUTS , 2007, Neurourology and urodynamics.

[24]  K. Andersson.  Bladder activation: afferent mechanisms. , 2002, Urology.

[25]  P. K. Smith,et al.  Measurement of protein using bicinchoninic acid. , 1985, Analytical biochemistry.

[26]  R. Buttyan,et al.  Cellular and molecular aspects of bladder hypertrophy. , 1997, European urology.