Prefrontal cortical projections to the hypothalamus in Macaque monkeys

The organization of projections from the macaque orbital and medial prefrontal cortex (OMPFC) to the hypothalamus and related regions of the diencephalon and midbrain was studied with retrograde and anterograde tracing techniques. Almost all of the prefrontal cortical projections to the hypothalamus arise from areas within the “medial prefrontal network,” as defined previously by Carmichael and Price ([1996] J. Comp. Neurol. 371:179–207). Outside of the OMPFC, only a few neurons in the temporal pole, anterior cingulate and insular cortex project to the hypothalamus. Axons from the OMPFC also innervate the basal forebrain, zona incerta, and ventral midbrain.

[1]  K H PRIBRAM,et al.  Respiratory and vascular responses in monkeys from temporal pole, insula, orbital surface and cingulate gyrus; a preliminary report. , 1949, Journal of neurophysiology.

[2]  P. Wall,et al.  Three cerebral cortical systems affecting autonomic function. , 1951, Journal of neurophysiology.

[3]  Delgado Jm.  Circulatory effects of cortical stimulation. , 1960 .

[4]  M. Mishkin,et al.  Projections from behaviorally-defined sectors of the prefrontal cortex to the basal ganglia, septum, and diencephalon of the monkey. , 1968, Experimental neurology.

[5]  W. Nauta.  The problem of the frontal lobe: a reinterpretation. , 1971, Journal of psychiatric research.

[6]  A. Hendrickson,et al.  The autoradiographic demonstration of axonal connections in the central nervous system. , 1972, Brain research.

[7]  A. Siegel,et al.  Effects of electrical stimulation of the lateral aspect of the prefrontal cortex upon attack behavior in cats , 1974, Brain Research.

[8]  Feeding behavior in monkeys with and without lesions of the hypothalamus. , 1976, The American journal of physiology.

[9]  D. Pfaff,et al.  Efferents from medial basal forebrain and hypothalamus in the rat. II. An autoradiographic study of the anterior hypothalamus , 2004, The Journal of comparative neurology.

[10]  R. L. McBride,et al.  Amygdaloid and pontine projections to the ventromedial nucleus of the hypothalamus , 1977, The Journal of comparative neurology.

[11]  J. Price,et al.  Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat , 1978, The Journal of comparative neurology.

[12]  R. M. Beckstead.  An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal‐projection (prefrontal) cortex in the rat , 1979, The Journal of comparative neurology.

[13]  J. Maunsell,et al.  Two‐dimensional maps of the cerebral cortex , 1980, The Journal of comparative neurology.

[14]  D. Amaral,et al.  An autoradiographic study of the projections of the central nucleus of the monkey amygdala , 1981, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[15]  H. Kita,et al.  Reciprocal connections between the lateral hypothalamus and the frontal cortex in the rat: Electrophysiological and anatomical observations , 1981, Brain Research.

[16]  Charles R. Gerfen,et al.  Visceral cortex: A direct connection from prefrontal cortex to the solitary nucleus in rat , 1982, Neuroscience Letters.

[17]  W. Cowan,et al.  A stereotaxic atlas of the brain of the cynomolgus monkey (Macaca fascicularis) , 1984, The Journal of comparative neurology.

[18]  D. Amaral,et al.  The afferent connections of the substantia innominata in the monkey, Macaca fascicularis , 1985, The Journal of comparative neurology.

[19]  C. Saper,et al.  Organization of cerebral cortical afferent systems in the rat. II. Hypothalamocortical projections , 1985, The Journal of comparative neurology.

[20]  R. Roth,et al.  Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin , 1989, The Journal of comparative neurology.

[21]  A. Damasio,et al.  Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli , 1990, Behavioural Brain Research.

[22]  E. Neafsey,et al.  Prefrontal cortical control of the autonomic nervous system: anatomical and physiological observations. , 1990, Progress in brain research.

[23]  D. Cechetto,et al.  Subcortical sites mediating sympathetic responses from insular cortex in rats. , 1990, The American journal of physiology.

[24]  T. R. Scott,et al.  Complex attributes of lateral hypothalamic neurons in the regulation of feeding of alert rhesus monkeys , 1990, Brain Research Bulletin.

[25]  J. D. Bruin.  Chapter 24 Social behaviour and the prefrontal cortex , 1991 .

[26]  B. Slotnick,et al.  Olfactory projections to the hypothalamus , 1991, The Journal of comparative neurology.

[27]  D. Cechetto,et al.  Autonomic responses and efferent pathways from the insular cortex in the rat , 1991, The Journal of comparative neurology.

[28]  A. Loewy.  Chapter 12 Forebrain nuclei involved in autonomic control , 1991 .

[29]  C. Saper,et al.  Organization of visceral and limbic connections in the insular cortex of the rat , 1991, The Journal of comparative neurology.

[30]  C. Saper,et al.  Efferent projections of the infralimbic cortex of the rat , 1991, The Journal of comparative neurology.

[31]  A. D. Smith,et al.  A monosynaptic pathway from an identified vasomotor centre in the medial prefrontal cortex to an autonomic area in the thoracic spinal cord , 1993, Neuroscience.

[32]  J. Price,et al.  The organization of projections from the mediodorsal nucleus of the thalamus to orbital and medial prefrontal cortex in macaque monkeys , 1993, The Journal of comparative neurology.

[33]  J. Price,et al.  Central olfactory connections in the macaque monkey , 1994, The Journal of comparative neurology.

[34]  M. T. Shipley,et al.  Columnar organization in the midbrain periaqueductal gray: modules for emotional expression? , 1994, Trends in Neurosciences.

[35]  J. Price,et al.  Architectonic subdivision of the orbital and medial prefrontal cortex in the macaque monkey , 1994, The Journal of comparative neurology.

[36]  A. Damasio,et al.  Insensitivity to future consequences following damage to human prefrontal cortex , 1994, Cognition.

[37]  E. Rolls,et al.  Gustatory, olfactory, and visual convergence within the primate orbitofrontal cortex , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[38]  J. Price,et al.  Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys , 1995, The Journal of comparative neurology.

[39]  A. Loewy,et al.  Central Command Neurons of the Sympathetic Nervous System: Basis of the Fight-or-Flight Response , 1995, Science.

[40]  J. Price,et al.  Sensory and premotor connections of the orbital and medial prefrontal cortex of macaque monkeys , 1995, The Journal of comparative neurology.

[41]  C. Saper.  The central autonomic system , 1995 .

[42]  S. Carmichael,et al.  Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys , 1996 .

[43]  M. Dallman,et al.  The Hypothalamic Ventromedial Nuclei Couple Activity in the Hypothalamo–Pituitary–Adrenal Axis to the Morning Fed or Fasted State , 1996, The Journal of Neuroscience.

[44]  A. Damasio,et al.  Deciding Advantageously Before Knowing the Advantageous Strategy , 1997, Science.

[45]  C. Saper,et al.  Leptin activates neurons in ventrobasal hypothalamus and brainstem. , 1997, Endocrinology.

[46]  J. Price,et al.  Prefrontal cortical projections to longitudinal columns in the midbrain periaqueductal gray in Macaque monkeys , 1998, The Journal of comparative neurology.