Mining the microbial dark matter

Microbiologists are finding new ways to explore the vast universe of unknown microbes in the hunt for antibiotics.

[1]  R. Lasken,et al.  Genomic DNA Amplification from a Single Bacterium , 2005, Applied and Environmental Microbiology.

[2]  R. Rosenfeld.  Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[3]  C. Fraser,et al.  Complete genome sequence of the Q-fever pathogen Coxiella burnetii , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[4]  R. Ismagilov,et al.  Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa , 2014, Proceedings of the National Academy of Sciences.

[5]  B. Birren,et al.  The “Most Wanted” Taxa from the Human Microbiome for Whole Genome Sequencing , 2012, PloS one.

[6]  T. Hackstadt,et al.  Developmental stage-specific metabolic and transcriptional activity of Chlamydia trachomatis in an axenic medium , 2012, Proceedings of the National Academy of Sciences.

[7]  Natalia N. Ivanova,et al.  Insights into the phylogeny and coding potential of microbial dark matter , 2013, Nature.

[8]  K. Lewis,et al.  A new antibiotic kills pathogens without detectable resistance , 2015, Nature.

[9]  Peter Cimermancic,et al.  A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics , 2014, Cell.

[10]  Christian Rinke,et al.  An environmental bacterial taxon with a large and distinct metabolic repertoire , 2014, Nature.

[11]  R. Heinzen,et al.  Host cell-free growth of the Q fever bacterium Coxiella burnetii , 2009, Proceedings of the National Academy of Sciences.