Heterozygous Meg2 Ablation Causes Intraocular Pressure Elevation and Progressive Glaucomatous Neurodegeneration
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G. Downey | S. Joachim | A. Faissner | B. Denecke | J. Woestmann | M. Palmhof | Yingchun Wang | J. Reinhard | Susanne Wiemann
[1] Manoj Kumar,et al. INGE GRUNDKE-IQBAL AWARD FOR ALZHEIMER’S RESEARCH: NEUROTOXIC REACTIVE ASTROCYTES ARE INDUCED BY ACTIVATED MICROGLIA , 2019, Alzheimer's & Dementia.
[2] J. den Hertog,et al. Recent advances in understanding the role of protein-tyrosine phosphatases in development and disease. , 2017, Developmental biology.
[3] Xianjun Zhu,et al. Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective , 2017, Proceedings of the National Academy of Sciences.
[4] G. MacGregor,et al. Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain , 2017, Journal of Neuroinflammation.
[5] S. Joachim,et al. Ischemic injury leads to extracellular matrix alterations in retina and optic nerve , 2017, Scientific Reports.
[6] Z. Zhao,et al. The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A* , 2016, The Journal of Biological Chemistry.
[7] S. Joachim,et al. Early remodelling of the extracellular matrix proteins tenascin‐C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model , 2016, Journal of cellular and molecular medicine.
[8] S. Joachim,et al. Simultaneous Complement Response via Lectin Pathway in Retina and Optic Nerve in an Experimental Autoimmune Glaucoma Model , 2016, Front. Cell. Neurosci..
[9] J. Salazar,et al. Retinal Macroglial Responses in Health and Disease , 2016, BioMed research international.
[10] James R. Tribble,et al. Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma , 2016, Molecular Neurodegeneration.
[11] S. John,et al. C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury , 2016, Molecular Neurodegeneration.
[12] J. Danias,et al. Differential Effects of C1qa Ablation on Glaucomatous Damage in Two Sexes in DBA/2NNia Mice , 2015, PloS one.
[13] E. Tamm,et al. The aqueous humor outflow pathways in glaucoma: A unifying concept of disease mechanisms and causative treatment. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[14] Y. Zhuo,et al. HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma , 2015, Journal of Neuroinflammation.
[15] C. Ehlken,et al. Increased Expression of Angiogenic and Inflammatory Proteins in the Vitreous of Patients with Ischemic Central Retinal Vein Occlusion , 2015, PloS one.
[16] M. Shibuya,et al. Erratum to: The guanine nucleotide exchange factor Vav3 regulates differentiation of progenitor cells in the developing mouse retina , 2015, Cell and Tissue Research.
[17] T. Langmann,et al. Retinal microglia: Just bystander or target for therapy? , 2015, Progress in Retinal and Eye Research.
[18] Duane D. Miller,et al. Insulin-like growth factor-1 binding protein 3 (IGFBP-3) promotes recovery from trauma-induced expression of inflammatory and apoptotic factors in retina. , 2014, Cytokine.
[19] T. Wong,et al. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. , 2014, Ophthalmology.
[20] T. Langmann,et al. Early-onset autosomal recessive cerebellar ataxia associated with retinal dystrophy: new human hotfoot phenotype caused by homozygous GRID2 deletion , 2014, Genetics in Medicine.
[21] N. Brecha,et al. Loss of outer retinal neurons and circuitry alterations in the DBA/2J mouse. , 2014, Investigative ophthalmology & visual science.
[22] S. Joachim,et al. Loss of inner retinal neurons after retinal ischemia in rats. , 2014, Investigative ophthalmology & visual science.
[23] J. Steinle,et al. Intravitreal Injection of IGFBP-3 Restores Normal Insulin Signaling in Diabetic Rat Retina , 2014, PloS one.
[24] Richard S. Smith,et al. Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice , 2013, Journal of Neuroinflammation.
[25] C. Print,et al. Zinc Finger Nuclease Mediated Knockout of ADP-Dependent Glucokinase in Cancer Cell Lines: Effects on Cell Survival and Mitochondrial Oxidative Metabolism , 2013, PloS one.
[26] C. R. Yates,et al. Insulin-like growth factor binding protein-3 inhibits monocyte adhesion to retinal endothelial cells in high glucose conditions , 2013, Molecular vision.
[27] G. Tezel. Immune regulation toward immunomodulation for neuroprotection in glaucoma. , 2013, Current opinion in pharmacology.
[28] P. Grudnik,et al. T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation. , 2012, Cell reports.
[29] T. Keenan,et al. Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera. , 2012, Investigative ophthalmology & visual science.
[30] S. John,et al. Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy. , 2012, Annual review of neuroscience.
[31] R. Nickells. The cell and molecular biology of glaucoma: mechanisms of retinal ganglion cell death. , 2012, Investigative ophthalmology & visual science.
[32] B. Morquette,et al. The molecular basis of retinal ganglion cell death in glaucoma , 2012, Progress in Retinal and Eye Research.
[33] P. Wiedemann,et al. Müller Glial Cells in Retinal Disease , 2011, Ophthalmologica.
[34] Mei Chen,et al. Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid , 2011, Molecular vision.
[35] P. Bora,et al. Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma. , 2011, Molecular immunology.
[36] Matthew A. Hibbs,et al. Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. , 2011, The Journal of clinical investigation.
[37] O. Witte,et al. Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells. , 2011, Blood.
[38] Guochun Chen,et al. Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse. , 2011, Investigative ophthalmology & visual science.
[39] P. Heiduschka,et al. Loss of retinal function in aged DBA/2J mice - New insights into retinal neurodegeneration. , 2010, Experimental eye research.
[40] H. Kaplan,et al. Oxidative stress and the regulation of complement activation in human glaucoma. , 2010, Investigative ophthalmology & visual science.
[41] T. Langmann,et al. Microglia in the healthy and degenerating retina: insights from novel mouse models. , 2010, Immunobiology.
[42] H. Quigley,et al. Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss , 2010, Glia.
[43] Masahiko Watanabe,et al. VAV2 and VAV3 as Candidate Disease Genes for Spontaneous Glaucoma in Mice and Humans , 2010, PloS one.
[44] A. Ullrich,et al. Protein tyrosine phosphatases expression during development of mouse superior colliculus , 2009, Experimental Brain Research.
[45] M. Vidal-Sanz,et al. Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas. , 2009, Investigative ophthalmology & visual science.
[46] J. Morrison,et al. Friend or foe? Resolving the impact of glial responses in glaucoma. , 2009, Journal of glaucoma.
[47] C. L. Schlamp,et al. Mouse models of retinal ganglion cell death and glaucoma. , 2009, Experimental eye research.
[48] G. Tezel. The role of glia, mitochondria, and the immune system in glaucoma. , 2009, Investigative ophthalmology & visual science.
[49] D. Badcock,et al. Spatial summation properties for magnocellular and parvocellular pathways in glaucoma. , 2009, Investigative ophthalmology & visual science.
[50] Young H. Kwon,et al. Disruption of the complement cascade delays retinal ganglion cell death following retinal ischemia-reperfusion. , 2008, Experimental eye research.
[51] C. McMaster,et al. Structure and function of the enigmatic Sec14 domain-containing proteins and the etiology of human disease , 2008 .
[52] M. Cordeiro,et al. Neuroprotection in Glaucoma: Drug-Based Approaches , 2008, Optometry and vision science : official publication of the American Academy of Optometry.
[53] C. Distler,et al. Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina , 2008, Neuroscience.
[54] John D. Lambris,et al. The Classical Complement Cascade Mediates CNS Synapse Elimination , 2007, Cell.
[55] V. Porciatti,et al. IOP-dependent retinal ganglion cell dysfunction in glaucomatous DBA/2J mice. , 2007, Investigative ophthalmology & visual science.
[56] Abbot F Clark,et al. Rodent Models for Glaucoma Retinopathy and Optic Neuropathy , 2007, Journal of glaucoma.
[57] P. Horner,et al. Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma , 2007, Glia.
[58] T. Langmann. Microglia activation in retinal degeneration , 2007, Journal of leukocyte biology.
[59] T. Mustelin,et al. Association of Protein-tyrosine Phosphatase MEG2 via Its Sec14p Homology Domain with Vesicle-trafficking Proteins* , 2007, Journal of Biological Chemistry.
[60] E. Wawrousek,et al. Expression of Mutated Mouse Myocilin Induces Open-Angle Glaucoma in Transgenic Mice , 2006, The Journal of Neuroscience.
[61] N. Tonks,et al. Protein tyrosine phosphatases: from genes, to function, to disease , 2006, Nature Reviews Molecular Cell Biology.
[62] C. L. Schlamp,et al. Decrease of cone opsin mRNA in experimental ocular hypertension. , 2006, Molecular vision.
[63] Young H. Kwon,et al. Retinal synthesis and deposition of complement components induced by ocular hypertension. , 2006, Experimental eye research.
[64] Elena Vecino,et al. Three experimental glaucoma models in rats: comparison of the effects of intraocular pressure elevation on retinal ganglion cell size and death. , 2006, Experimental eye research.
[65] J. Danias,et al. Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes. , 2006, Investigative ophthalmology & visual science.
[66] C. McKerlie,et al. Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function , 2005, The Journal of experimental medicine.
[67] C. O'brien,et al. Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells. , 2005, Glia.
[68] R. Masland,et al. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice , 2005, The Journal of cell biology.
[69] Ruaidhrí P Kirwan,et al. Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro. , 2005, Molecular vision.
[70] Michael G. Anderson,et al. Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration. , 2005, Visual neuroscience.
[71] R. Weinreb,et al. The importance of models in glaucoma research. , 2005, Journal of glaucoma.
[72] Makoto Nakamura,et al. Long-term glial reactivity in rat retinas ipsilateral and contralateral to experimental glaucoma. , 2005, Experimental eye research.
[73] Jean YH Yang,et al. Bioconductor: open software development for computational biology and bioinformatics , 2004, Genome Biology.
[74] Li Guo,et al. Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[75] N. Bottini,et al. Control of vesicle fusion by a tyrosine phosphatase , 2004, Nature Cell Biology.
[76] E. Woldemussie,et al. Müller cell response to laser‐induced increase in intraocular pressure in rats , 2004, Glia.
[77] Joanna M. Sasin,et al. Protein Tyrosine Phosphatases in the Human Genome , 2004, Cell.
[78] K. Brown,et al. Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure. , 2004, Investigative ophthalmology & visual science.
[79] M. Wax,et al. The immune system and glaucoma , 2004, Current opinion in ophthalmology.
[80] A. Godzik,et al. Homotypic Secretory Vesicle Fusion Induced by the Protein Tyrosine Phosphatase MEG2 Depends on Polyphosphoinositides in T Cells1 , 2003, The Journal of Immunology.
[81] Z. Zhao,et al. PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells. , 2003, Blood.
[82] T. Filippopoulos,et al. Quantitative analysis of retinal ganglion cell (RGC) loss in aging DBA/2NNia glaucomatous mice: comparison with RGC loss in aging C57/BL6 mice. , 2003, Investigative ophthalmology & visual science.
[83] P. Lombroso,et al. Receptor and nonreceptor protein tyrosine phosphatases in the nervous system , 2003, Cellular and Molecular Life Sciences CMLS.
[84] F. Gage,et al. Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[85] P. Kaufman,et al. Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma , 2003, Progress in Retinal and Eye Research.
[86] Rafael A Irizarry,et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.
[87] David Zurakowski,et al. Effects of anti-glaucoma medications on gangion cell survival: the DBA/2J mouse model , 2002, Vision Research.
[88] J E Morgan,et al. Retinal ganglion cell shrinkage in glaucoma. , 2002, Journal of glaucoma.
[89] G. Horgan,et al. Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR , 2002 .
[90] F. Horn,et al. The a-wave of the dark adapted electroretinogram in glaucomas: are photoreceptors affected? , 2001, The British journal of ophthalmology.
[91] K. Reid,et al. C1q: structure, function, and receptors. , 2000, Immunopharmacology.
[92] Hideya Uchida,et al. Retinal ganglion cell death in experimental glaucoma , 2000, The British journal of ophthalmology.
[93] J. Morrison,et al. Chronology of optic nerve head and retinal responses to elevated intraocular pressure. , 2000, Investigative ophthalmology & visual science.
[94] S. John,et al. Mouse genetics: a tool to help unlock the mechanisms of glaucoma. , 1999, Journal of glaucoma.
[95] J. Hertog. Protein-tyrosine phosphatases in development , 1999, Mechanisms of Development.
[96] H. Quigley,et al. Neuronal death in glaucoma , 1999, Progress in Retinal and Eye Research.
[97] T H Roderick,et al. Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. , 1998, Investigative ophthalmology & visual science.
[98] S. Sharma,et al. The patterns of retinal ganglion cell death in hypertensive eyes , 1998, Brain Research.
[99] S. Lipton,et al. Molecular basis of glutamate toxicity in retinal ganglion cells , 1997, Vision Research.
[100] R. Strom,et al. Genetic and Environmental Control of Variation in Retinal Ganglion Cell Number in Mice , 1996, The Journal of Neuroscience.
[101] B. Neel,et al. From Form to Function: Signaling by Protein Tyrosine Phosphatases , 1996, Cell.
[102] J. Nathans,et al. Molecular biology of retinal ganglion cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[103] P. Majerus,et al. Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[104] G. Dunkelberger,et al. Chronic glaucoma selectively damages large optic nerve fibers. , 1987, Investigative ophthalmology & visual science.
[105] A. Stoker. RPTPs in axons, synapses and neurology. , 2015, Seminars in cell & developmental biology.
[106] M. Shibuya,et al. The guanine nucleotide exchange factor Vav3 regulates differentiation of progenitor cells in the developing mouse retina , 2014, Cell and Tissue Research.
[107] S. Ali,et al. Spatiotemporal distribution of chondroitin sulfate proteoglycans in the developing mouse retina and optic nerve. , 2011, The Journal of veterinary medical science.
[108] S. Hardy,et al. Inside the human cancer tyrosine phosphatome , 2010, Nature Reviews Cancer.
[109] J. Danias,et al. A role for complement in glaucoma? , 2010, Advances in experimental medicine and biology.
[110] Nunzio Bottini,et al. Protein tyrosine phosphatases and the immune response , 2005, Nature Reviews Immunology.
[111] M. Rogalińska. Alterations in cell nuclei during apoptosis. , 2002, Cellular & molecular biology letters.