Interleukin-10 Promoter Polymorphism is Associated with the Predisposition to the Development of IgA Nephropathy and Focal Segmental Glomerulosclerosis in Korea

The roles of interleukin-10 (IL-10) have been emphasized in several models of glomerulonephritis (GN). Three biallelic polymorphisms within the IL-10 promoter region, at positions -1,082, -819, and -592 from the transcription initiation site, were shown to affect the level of IL-10 production. To investigate the effect of IL-10 promoter polymorphisms on the predisposition to development of GN in Korea, IL-10 promoter polymorphisms were assayed by polymerase chain reaction followed by restriction fragment length polymorphism in 108 patients with IgA nephropathy (IgAN), 49 focal segmental glomerulosclerosis (FSGS), and 100 healthy controls. In comparison with the control, the frequency of -1,082*G alleles were lower in IgAN and the frequencies of -592*C and -819*C were lower in FSGS, respectively. As for the haplotype, GCC haplotype was less frequent among IgAN than the control and ATA haplotype was more frequent among FSGS than the control (p<0.05). The frequency of intermediate producer genotypes (GCC/ACC and GCC/ATA) were lower among IgAN or FSGS than the control. Our findings suggested that IL-10 promoter polymorphism predisposed to the development of IgAN and FSGS in Korean patients.

[1]  K. Ivens,et al.  Association of interleukin-10 gene G-1082A polymorphism with the progression of primary glomerulonephritis. , 2004, Kidney international.

[2]  Tadashi Yamamoto,et al.  Suppression of experimental crescentic glomerulonephritis by interleukin-10 gene transfer. , 2004, Kidney international.

[3]  J. Miyazaki,et al.  Hydrodynamics-based delivery of the viral interleukin-10 gene suppresses experimental crescentic glomerulonephritis in Wistar–Kyoto rats , 2003, Gene Therapy.

[4]  S. Paik,et al.  Suppression of glomerulosclerosis by adenovirus-mediated IL-10 expression in the kidney , 2003, Gene Therapy.

[5]  J. McNiff,et al.  IL-10 Regulates Murine Lupus1 , 2002, The Journal of Immunology.

[6]  D. Power,et al.  Interleukin‐10 inhibits experimental mesangial proliferative glomerulonephritis , 2002, Clinical and experimental immunology.

[7]  A. Demaine,et al.  A study of cytokine gene polymorphisms and protein secretion in renal transplantation. , 2001, Transplant immunology.

[8]  C. Ahn,et al.  Th1/Th2 predominance and proinflammatory cytokines determine the clinicopathological severity of IgA nephropathy. , 2001, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[9]  P. Tipping,et al.  Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritis. , 2000, Kidney international.

[10]  Chi-hung Cheng,et al.  Impact of interleukin-1 receptor antagonist and tumor necrosis factor-α gene polymorphism on IgA nephropathy , 2000 .

[11]  C. Navarrete,et al.  Allele frequencies of polymorphisms of the tumour necrosis factor-alpha, interleukin-10, interferon-gamma and interleukin-2 genes in a North European Caucasoid group from the UK. , 2000, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics.

[12]  P. Tipping,et al.  J Am Soc Nephrol 11: 262–269, 2000 Interleukin-10 Inhibits Macrophage-Induced Glomerular Injury , 2022 .

[13]  P. Whorwell,et al.  Interleukin-10 (IL-10) genotypes in inflammatory bowel disease. , 1999, Tissue antigens.

[14]  D. Purdie,et al.  Interleukin‐10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa , 1999, Hepatology.

[15]  Paul,et al.  Cytokine gene polymorphisms predict acute graft rejection following renal transplantation. , 1999, Kidney international.

[16]  V. Pravica,et al.  Genotyping for polymorphisms in interferon-γ, interleukin-10, transforming growth factor-β1 and tumour necrosis factor-α genes: a technical report , 1998 .

[17]  E. Ritz,et al.  In situ upregulation of IL-10 reflects the activity of human glomerulonephritides. , 1998, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[18]  J. Lanchbury,et al.  Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus. , 1998, Arthritis and rheumatism.

[19]  Atkins,et al.  Interleukin‐10 differentially modulates MHC class II expression by mesangial cells and macrophages in vitro and in vivo , 1998, Immunology.

[20]  L. Borish,et al.  Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10). , 1997, American journal of respiratory and critical care medicine.

[21]  R. Atkins,et al.  Effect of interleukin-10 treatment on crescentic glomerulonephritis in rats. , 1997, Kidney international.

[22]  R. Atkins,et al.  Interleukin-10 is a mesangial cell growth factor in vitro and in vivo. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[23]  S. Rich,et al.  Genetic linkage analysis of growth factor loci and end-stage renal disease in African Americans. , 1997, Kidney international.

[24]  P. Tipping,et al.  Immune modulation with interleukin‐4 and interleukin‐10 prevents crescent formation and glomerular injury in experimental glomerulonephritis , 1997, European journal of immunology.

[25]  M. Lazarus,et al.  An investigation of polymorphism in the interleukin-10 gene promoter. , 1997, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics.

[26]  M. Howard,et al.  Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice , 1994, The Journal of experimental medicine.

[27]  G. Hitman,et al.  Autoimmune renal disease and tumour necrosis factor beta gene polymorphism. , 1993, Clinical nephrology.

[28]  Lee Yk,et al.  The Impact of Gene Polymorphisms of Interleukin-10 and Interferon-gamma on the Clinical Courses of Renal Transplant Patients in Korea. , 2002 .

[29]  R. Coffman,et al.  Interleukin-10 and the interleukin-10 receptor. , 2001, Annual review of immunology.

[30]  W. Ollier,et al.  IL-10 gene promoter polymorphisms in rheumatoid arthritis. , 1998, Scandinavian journal of rheumatology.

[31]  Dieter Kube,et al.  Mapping of the human IL10 gene and further characterization of the 5’ flanking sequence , 1997, Immunogenetics.