Engagement of brain areas implicated in processing inner speech in people with auditory hallucinations.

BACKGROUND The neurocognitive basis of auditory hallucinations is unclear, but there is increasing evidence implicating abnormalities in processing inner speech. Previous studies have shown that people with schizophrenia who were prone to auditory hallucinations demonstrated attenuated activation of brain areas during the monitoring of inner speech. AIMS To investigate whether the same pattern of functional abnormalities would be evident as the rate of inner speech production was varied. METHOD Eight people with schizophrenia who had a history of prominent auditory hallucinations and eight control participants were studied using functional magnetic resonance imaging while the rate of inner speech generation was varied experimentally. RESULTS When the rate of inner speech generation was increased, the participants with schizophrenia showed a relatively attenuated response in the right temporal, parietal, parahippocampal and cerebellar cortex. CONCLUSIONS In people with schizophrenia who are prone to auditory hallucinations, increasing the demands on the processing of inner speech is associated with attenuated engagement of the brain areas implicated in verbal self-monitoring.

[1]  S. Lawrie,et al.  Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in schizophrenic subjects and normal controls , 2001, Psychiatry Research: Neuroimaging.

[2]  D. Wolpert,et al.  Central cancellation of self-produced tickle sensation , 1998, Nature Neuroscience.

[3]  Karl J. Friston,et al.  Regional Brain Activity in Chronic Schizophrenic Patients during the Performance of a Verbal Fluency Task , 1995, British Journal of Psychiatry.

[4]  R. Murray,et al.  Modulation of activity in temporal cortex during generation of inner speech , 2001, NeuroImage.

[5]  P. Mu¨ller-Preuss,et al.  Inhibition of auditory cortical neurons during phonation , 1981, Brain Research.

[6]  M J Brammer,et al.  A functional study of auditory verbal imagery , 2001, Psychological Medicine.

[7]  R. Murray,et al.  Functional anatomy of auditory verbal imagery in schizophrenic patients with auditory hallucinations. , 2000, The American journal of psychiatry.

[8]  J. Rawlins,et al.  The neuropsychology of schizophrenia , 1991, Behavioral and Brain Sciences.

[9]  J. Desmond,et al.  Hemispheric asymmetry for emotional stimuli detected with fMRI , 1998, Neuroreport.

[10]  S. Skare,et al.  Abnormal brain white matter in schizophrenia: a diffusion tensor imaging study , 2001, Neuroreport.

[11]  R. Murray,et al.  The Neural Correlates of Inner Speech and Auditory Verbal Imagery in Schizophrenia: Relationship to Auditory Verbal Hallucinations , 1996, British Journal of Psychiatry.

[12]  M. Annett.  A classification of hand preference by association analysis. , 1970, British journal of psychology.

[13]  Alan C. Evans,et al.  Modulation of Cerebral Blood Flow in the Human Auditory Cortex During Speech: Role of Motor‐to‐sensory Discharges , 1996, European Journal of Neuroscience.

[14]  G. Lindinger,et al.  Supplementary Motor Area Activation Preceding Voluntary Movement Is Detectable with a Whole-Scalp Magnetoencephalography System , 2000, NeuroImage.

[15]  D. Tank,et al.  Brain magnetic resonance imaging with contrast dependent on blood oxygenation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Michael I. Jordan,et al.  An internal model for sensorimotor integration. , 1995, Science.

[17]  P. Basser,et al.  MR diffusion tensor spectroscopy and imaging. , 1994, Biophysical journal.

[18]  C. Frith,et al.  Towards a Neuropsychology of Schizophrenia , 1988, British Journal of Psychiatry.

[19]  H. Kornhuber,et al.  Distribution of readiness potential, pre-motion positivity, and motor potential of the human cerebral cortex preceding voluntary finger movements , 2004, Experimental Brain Research.

[20]  A. D. de Crespigny,et al.  Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging. , 1999, Archives of general psychiatry.

[21]  Karl J. Friston,et al.  Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations , 2002, Biological Psychiatry.

[22]  T. Crow,et al.  Schizophrenia as an anomaly of development of cerebral asymmetry. A postmortem study and a proposal concerning the genetic basis of the disease. , 1989, Archives of general psychiatry.

[23]  G. Curio,et al.  Speaking modifies voice‐evoked activity in the human auditory cortex , 2000, Human brain mapping.

[24]  S. Ogawa.  Brain magnetic resonance imaging with contrast-dependent oxygenation , 1990 .

[25]  O. Creutzfeldt,et al.  Neuronal activity in the human lateral temporal lobe , 2004, Experimental Brain Research.

[26]  R. Murray,et al.  Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging. , 2000, Archives of general psychiatry.

[27]  K. Heilman,et al.  Understanding emotional prosody activates right hemisphere regions. , 1996, Archives of neurology.

[28]  Karl J. Friston,et al.  Functional anatomy of verbal fluency in people with schizophrenia and those at genetic risk , 2000, Schizophrenia Research.

[29]  Philip K. McGuire,et al.  Modulation of activity in temporal cortex during generation of inner speech , 2002, Human brain mapping.