Prodrug-based nanoparticulate drug delivery strategies for cancer therapy.

[1]  Anjie Dong,et al.  Correction: Tailor-made gemcitabine prodrug nanoparticles from well-defined drug-polymer amphiphiles prepared by controlled living radical polymerization for cancer chemotherapy. , 2014, Journal of materials chemistry. B.

[2]  Yu-Zhong Wang,et al.  A prodrug strategy based on chitosan for efficient intracellular anticancer drug delivery , 2014, Nanotechnology.

[3]  P. Couvreur,et al.  Significant Tumor Growth Inhibition from Naturally Occurring Lipid-Containing Polymer Prodrug Nanoparticles Obtained by the Drug-Initiated Method , 2014 .

[4]  P. Couvreur,et al.  Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy. , 2014, Chemical communications.

[5]  Jinming Hu,et al.  Engineering responsive polymer building blocks with host-guest molecular recognition for functional applications. , 2014, Accounts of chemical research.

[6]  Chaoliang He,et al.  Core-cross-linked micellar nanoparticles from a linear-dendritic prodrug for dual-responsive drug delivery , 2014 .

[7]  J. DeSimone,et al.  Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity. , 2014, Nano letters.

[8]  M. Sloff,et al.  Tailored doxorubicin-hyaluronan conjugate as a potent anticancer glyco-drug: an alternative to prodrug approach. , 2014, Macromolecular bioscience.

[9]  Jian-tao Lin,et al.  A macromolecular prodrug strategy for combinatorial drug delivery. , 2014, Journal of colloid and interface science.

[10]  Jin Sun,et al.  Emerging integrated nanohybrid drug delivery systems to facilitate the intravenous-to-oral switch in cancer chemotherapy. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[11]  I. Kwon,et al.  Complex adaptive therapeutic strategy (CATS) for cancer. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[12]  J. Choi,et al.  Enhanced splicing correction effect by an oligo-aspartic acid-PNA conjugate and cationic carrier complexes. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[13]  P. Couvreur,et al.  Combined antitumoral therapy with nanoassemblies of bolaform polyisoprenoyl paclitaxel/gemcitabine prodrugs , 2014 .

[14]  P. Couvreur,et al.  Recent trends in the design of anticancer polymer prodrug nanocarriers , 2014 .

[15]  Xiaoyang Xu,et al.  Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. , 2014, Advanced drug delivery reviews.

[16]  Felix Kratz,et al.  A facile approach for dual-responsive prodrug nanogels based on dendritic polyglycerols with minimal leaching. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[17]  U. Schubert,et al.  Self-assembling doxorubicin-tocopherol succinate prodrug as a new drug delivery system: synthesis, characterization, and in vitro and in vivo anticancer activity. , 2014, Bioconjugate chemistry.

[18]  Wei-Hai Chen,et al.  Multi-functional envelope-type nanoparticles assembled from amphiphilic peptidic prodrug with improved anti-tumor activity. , 2014, ACS applied materials & interfaces.

[19]  G. Pastorin,et al.  Enhanced cytotoxicity to cancer cells by mitochondria-targeting MWCNTs containing platinum(IV) prodrug of cisplatin. , 2014, Biomaterials.

[20]  Yujiang Fan,et al.  High drug loading pH-sensitive pullulan-DOX conjugate nanoparticles for hepatic targeting. , 2014, Journal of biomedical materials research. Part A.

[21]  X. Jing,et al.  Photosensitive Pt(IV)-azide prodrug-loaded nanoparticles exhibit controlled drug release and enhanced efficacy in vivo. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[22]  Jun Lin,et al.  In vivo multimodality imaging and cancer therapy by near-infrared light-triggered trans-platinum pro-drug-conjugated upconverison nanoparticles. , 2013, Journal of the American Chemical Society.

[23]  G. Zhai,et al.  Polymer-drug conjugates: present state of play and future perspectives. , 2013, Drug discovery today.

[24]  T. Minko,et al.  Nanotechnology approaches for personalized treatment of multidrug resistant cancers. , 2013, Advanced drug delivery reviews.

[25]  Haijun Yu,et al.  Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor. , 2013, Advanced drug delivery reviews.

[26]  E. Simanek,et al.  Design, synthesis and biological assessment of a triazine dendrimer with approximately 16 Paclitaxel groups and 8 PEG groups. , 2013, Molecular pharmaceutics.

[27]  Xianglong Hu,et al.  Polyprodrug amphiphiles: hierarchical assemblies for shape-regulated cellular internalization, trafficking, and drug delivery. , 2013, Journal of the American Chemical Society.

[28]  Z. Gu,et al.  Biodegradable and amphiphilic block copolymer-doxorubicin conjugate as polymeric nanoscale drug delivery vehicle for breast cancer therapy. , 2013, Biomaterials.

[29]  Bulent Ozpolat,et al.  Nanotechnology in cancer therapy , 2013, Journal of drug targeting.

[30]  Robert Langer,et al.  Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug , 2013, Proceedings of the National Academy of Sciences.

[31]  Julie Mougin,et al.  Novel isoprenoyl nanoassembled prodrug for paclitaxel delivery. , 2013, Bioconjugate chemistry.

[32]  Jing Zhao,et al.  Prodrug micelle-based nanomedicine for cancer treatment. , 2013, Nanomedicine.

[33]  V. Torchilin,et al.  Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety , 2013, Proceedings of the National Academy of Sciences.

[34]  Yuanyuan Liu,et al.  pH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma. , 2013, Biomaterials.

[35]  Si-Shen Feng,et al.  Targeted co-delivery of docetaxel, cisplatin and herceptin by vitamin E TPGS-cisplatin prodrug nanoparticles for multimodality treatment of cancer. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[36]  Zhishen Ge,et al.  Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance. , 2013, Chemical Society reviews.

[37]  Ronit Satchi-Fainaro,et al.  Nano-sized polymers and liposomes designed to deliver combination therapy for cancer. , 2013, Current opinion in biotechnology.

[38]  J. Goodisman,et al.  Cyclodextrin capped gold nanoparticles as a delivery vehicle for a prodrug of cisplatin. , 2013, Inorganic chemistry.

[39]  Jianbin Tang,et al.  Tumor Redox Heterogeneity‐Responsive Prodrug Nanocapsules for Cancer Chemotherapy , 2013, Advanced materials.

[40]  P. Couvreur,et al.  Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy. , 2013, Biomacromolecules.

[41]  Ru Cheng,et al.  Acetal-linked paclitaxel prodrug micellar nanoparticles as a versatile and potent platform for cancer therapy. , 2013, Biomacromolecules.

[42]  P. Couvreur,et al.  Polyisoprenoyl gemcitabine conjugates self assemble as nanoparticles, useful for cancer therapy. , 2013, Cancer letters.

[43]  Jianbin Tang,et al.  Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery. , 2013, Biomaterials.

[44]  Shirui Mao,et al.  Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram. , 2013, ACS nano.

[45]  S. Vinogradov,et al.  Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors. , 2013, Bioconjugate chemistry.

[46]  Amolkumar Karwa,et al.  Poly(ethylene oxide)-block-polyphosphester-based Paclitaxel Conjugates as a Platform for Ultra-high Paclitaxel-loaded Multifunctional Nanoparticles. , 2013, Chemical science.

[47]  Jian Huang,et al.  Novel SN38 conjugate-forming nanoparticles as anticancer prodrug: in vitro and in vivo studies. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[48]  Kui Luo,et al.  Dendronized heparin-doxorubicin conjugate based nanoparticle as pH-responsive drug delivery system for cancer therapy. , 2013, Biomaterials.

[49]  James H. Doroshow,et al.  Safety and feasibility of targeted agent combinations in solid tumours , 2013, Nature Reviews Clinical Oncology.

[50]  Tao Liu,et al.  Photo-degradable, protein-polyelectrolyte complex-coated, mesoporous silica nanoparticles for controlled co-release of protein and model drugs. , 2013, Macromolecular rapid communications.

[51]  F. Atyabi,et al.  A review of polysaccharide cytotoxic drug conjugates for cancer therapy. , 2013, Carbohydrate polymers.

[52]  Honggang Cui,et al.  Supramolecular nanostructures formed by anticancer drug assembly. , 2013, Journal of the American Chemical Society.

[53]  Jonathan R. McDaniel,et al.  Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation. , 2013, Angewandte Chemie.

[54]  P. Couvreur,et al.  Nanoparticles with in vivo anticancer activity from polymer prodrug amphiphiles prepared by living radical polymerization. , 2013, Angewandte Chemie.

[55]  Z. Gu,et al.  The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron-doxorubicin conjugates for cancer therapy. , 2013, Biomaterials.

[56]  Jianbin Tang,et al.  Self-assembling doxorubicin prodrug forming nanoparticles for cancer chemotherapy: synthesis and anticancer study in vitro and in vivo. , 2013, Journal of materials chemistry. B.

[57]  Yongjun Wang,et al.  The holistic 3M modality of drug delivery nanosystems for cancer therapy. , 2013, Nanoscale.

[58]  P. Couvreur,et al.  Improving the Antitumor Activity of Squalenoyl‐Paclitaxel Conjugate Nanoassemblies by Manipulating the Linker between Paclitaxel and Squalene , 2013, Advanced healthcare materials.

[59]  X. Jing,et al.  Co-delivery of daunomycin and oxaliplatin by biodegradable polymers for safer and more efficacious combination therapy. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[60]  Shyh-Dar Li,et al.  A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[61]  Jianbin Tang,et al.  Conjugate of Pt(IV)-histone deacetylase inhibitor as a prodrug for cancer chemotherapy. , 2012, Molecular pharmaceutics.

[62]  J. Hubbell,et al.  Reduction-sensitive tioguanine prodrug micelles. , 2012, Molecular pharmaceutics.

[63]  X. Jing,et al.  A prodrug strategy to deliver cisplatin(IV) and paclitaxel in nanomicelles to improve efficacy and tolerance. , 2012, Biomaterials.

[64]  Michael J Sailor,et al.  Hybrid Nanoparticles for Detection and Treatment of Cancer , 2012, Advanced materials.

[65]  P. Couvreur,et al.  Squalenoylation: a generic platform for nanoparticular drug delivery. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[66]  Hao Bai,et al.  Effect of molecular weight of PGG-paclitaxel conjugates on in vitro and in vivo efficacy. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[67]  Jia-You Fang,et al.  Nanoparticles as delivery carriers for anticancer prodrugs , 2012, Expert opinion on drug delivery.

[68]  Omid C. Farokhzad,et al.  α(V)β(3) integrin-targeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrug. , 2012, ACS nano.

[69]  Mary E Napier,et al.  Incorporation and controlled release of silyl ether prodrugs from PRINT nanoparticles. , 2012, Journal of the American Chemical Society.

[70]  Shyh-Dar Li,et al.  Preclinical pharmacokinetic, biodistribution, and anti-cancer efficacy studies of a docetaxel-carboxymethylcellulose nanoparticle in mouse models. , 2012, Biomaterials.

[71]  S. Achilefu,et al.  A paclitaxel-conjugated adenovirus vector for targeted drug delivery for tumor therapy. , 2012, Biomaterials.

[72]  K. Ulbrich,et al.  Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[73]  Wentao Lu,et al.  Acid-activatable prodrug nanogels for efficient intracellular doxorubicin release. , 2011, Biomacromolecules.

[74]  Hannu Raunio,et al.  Prodrugs—from Serendipity to Rational Design , 2011, Pharmacological Reviews.

[75]  Donglu Shi,et al.  Self-assembling nanomicelles of a novel camptothecin prodrug engineered with a redox-responsive release mechanism. , 2011, Chemical communications.

[76]  Sonke Svenson,et al.  Preclinical to clinical development of the novel camptothecin nanopharmaceutical CRLX101. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[77]  C. van Nostrum,et al.  Nanobody-shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[78]  I. Manners,et al.  Stimulus-responsive self-assembly: reversible, redox-controlled micellization of polyferrocenylsilane diblock copolymers. , 2011, Journal of the American Chemical Society.

[79]  D. Yan,et al.  Polymeric micelles with water-insoluble drug as hydrophobic moiety for drug delivery. , 2011, Biomacromolecules.

[80]  J. Laubach,et al.  Future directions of next-generation novel therapies, combination approaches, and the development of personalized medicine in myeloma. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[81]  B. Lundberg.  Preparation and characterization of polymeric pH-sensitive STEALTH® nanoparticles for tumor delivery of a lipophilic prodrug of paclitaxel. , 2011, International journal of pharmaceutics.

[82]  Chun Wang,et al.  Block copolymer micelles with acid-labile ortho ester side-chains: Synthesis, characterization, and enhanced drug delivery to human glioma cells. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[83]  P. Couvreur,et al.  Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics. , 2011, ACS nano.

[84]  Omid C Farokhzad,et al.  Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo , 2011, Proceedings of the National Academy of Sciences.

[85]  P. Couvreur,et al.  Prodrug-based intracellular delivery of anticancer agents. , 2011, Advanced drug delivery reviews.

[86]  A. Ohtsu,et al.  Phase I Study of NK012, a Novel SN-38–Incorporating Micellar Nanoparticle, in Adult Patients with Solid Tumors , 2010, Clinical Cancer Research.

[87]  Robert Langer,et al.  Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy , 2010, Proceedings of the National Academy of Sciences.

[88]  K. Ulbrich,et al.  Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. , 2010, Biomaterials.

[89]  B. Zhang,et al.  Amphiphilic curcumin conjugate-forming nanoparticles as anticancer prodrug and drug carriers: in vitro and in vivo effects. , 2010, Nanomedicine.

[90]  M. Thanou,et al.  Targeting nanoparticles to cancer. , 2010, Pharmacological research.

[91]  Ashutosh Chilkoti,et al.  Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery. , 2010, Nanomedicine.

[92]  Norbert Maurer,et al.  Development of a weak-base docetaxel derivative that can be loaded into lipid nanoparticles. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[93]  K. Ulbrich,et al.  HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release. , 2010, Molecular pharmaceutics.

[94]  Fabian Kiessling,et al.  Polymeric nanomedicines for image-guided drug delivery and tumor-targeted combination therapy , 2010 .

[95]  Maohong Fan,et al.  Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery. , 2010, Journal of the American Chemical Society.

[96]  Liangfang Zhang,et al.  Polymer--cisplatin conjugate nanoparticles for acid-responsive drug delivery. , 2010, ACS nano.

[97]  Changlong Sun,et al.  Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[98]  J. Xiang,et al.  The Use of Amino Acid Linkers in the Conjugation of Paclitaxel with Hyaluronic Acid as Drug Delivery System: Synthesis, Self-Assembled Property, Drug Release, and In Vitro Efficiency , 2010, Pharmaceutical Research.

[99]  Mingqiang Zhu,et al.  Heparin-paclitaxel conjugates as drug delivery system: synthesis, self-assembly property, drug release, and antitumor activity. , 2009, Bioconjugate chemistry.

[100]  Ruth Duncan,et al.  Development of HPMA copolymer-anticancer conjugates: clinical experience and lessons learnt. , 2009, Advanced drug delivery reviews.

[101]  María J. Vicent,et al.  Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines. , 2009, Advanced drug delivery reviews.

[102]  Ashutosh Chilkoti,et al.  Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumors after a single injection , 2009, Nature materials.

[103]  R. Prud’homme,et al.  Modulating the therapeutic activity of nanoparticle delivered paclitaxel by manipulating the hydrophobicity of prodrug conjugates. , 2008, Journal of medicinal chemistry.

[104]  P. McCarron,et al.  Incorporation of novel 1-alkylcarbonyloxymethyl prodrugs of 5-fluorouracil into poly(lactide-co-glycolide) nanoparticles. , 2008, International journal of pharmaceutics.

[105]  Glen S. Kwon,et al.  Paclitaxel Prodrugs with Sustained Release and High Solubility in Poly(ethylene glycol)-b-poly(ε-caprolactone) Micelle Nanocarriers: Pharmacokinetic Disposition, Tolerability, and Cytotoxicity , 2007, Pharmaceutical Research.

[106]  T. Onda,et al.  Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors. , 2006, Cancer research.

[107]  Robert J. Lee,et al.  A Folate Receptor–Targeted Lipid Nanoparticle Formulation for a Lipophilic Paclitaxel Prodrug , 2004, Pharmaceutical Research.

[108]  H. Ueno,et al.  Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin , 2004, British Journal of Cancer.

[109]  A. Maitra,et al.  Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[110]  T. Okano,et al.  Development of the polymer micelle carrier system for doxorubicin. , 2001, Journal of controlled release : official journal of the Controlled Release Society.