The synthesis and conformation of dihydroxy-cyclo( d-Pro- l-Pro- d-Pro- l-Pro)

Abstract The first synthesis of a derivative of cyclo( d -Pro- l -Pro- d -Pro- l -Pro) is reported. The convergent route to the molecule is amenable to the synthesis of gram quantities of the desired compound. The cyclization of the linear tetramer was found to give specifically one conformation of the 12 member macrocycle. The structural assignment, by 2D NMR, of the favored conformation is also reported.