Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis

[1]  H. Thoenen,et al.  Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy , 1992, Nature.

[2]  M. Sacher,et al.  Okadaic acid induces the rapid and reversible disruption of the neurofilament network in rat dorsal root ganglion neurons. , 1992, Biochemical and biophysical research communications.

[3]  P. D. de Jong,et al.  Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). , 1992, Genomics.

[4]  J. Guénet,et al.  Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11. , 1992, Genomics.

[5]  Scott T. Brady,et al.  Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells , 1992, Cell.

[6]  J. Mazurkiewicz,et al.  Neurofilament Distribution is Altered in the Mnd (Motor Neuron Degeneration) Mouse , 1991, Journal of neuropathology and experimental neurology.

[7]  J. Gearhart,et al.  Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber , 1990, The Journal of cell biology.

[8]  U Aebi,et al.  Effect of aluminum and other multivalent cations on neurofilaments in vitro: an electron microscopic study. , 1990, Journal of structural biology.

[9]  N. Hirokawa,et al.  Molecular architecture of the neurofilament. II. Reassembly process of neurofilament L protein in vitro. , 1990, Journal of molecular biology.

[10]  Moses Rodriguez,et al.  Ultrastructural, Morphometric, and Immunocytochemical Study of Anterior Hom Cells in Mice with “Wasted” Mutation , 1989, Journal of neuropathology and experimental neurology.

[11]  S. Maruyama,et al.  Swellings of proximal axons in a case of motor neuron disease , 1989, Annals of neurology.

[12]  F. Grosveld,et al.  Sequence and structure of the mouse gene coding for the largest neurofilament subunit. , 1988, Gene.

[13]  R. Lazzarini,et al.  The structure and organization of the human heavy neurofilament subunit (NF‐H) and the gene encoding it. , 1988, The EMBO journal.

[14]  D. Soifer,et al.  cDNA coding for the tail region of the high molecular weight rabbit neurofilament protein NF‐H , 1988, Journal of neuroscience research.

[15]  L. Otvos,et al.  Identification of the major multiphosphorylation site in mammalian neurofilaments. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[16]  J. Griffin,et al.  Axonal transport in neurological disease , 1988, Annals of neurology.

[17]  P M Steinert,et al.  Molecular and cellular biology of intermediate filaments. , 1988, Annual review of biochemistry.

[18]  J. Julien,et al.  Expression and assembly of a human neurofilament protein in transgenic mice provide a novel neuronal marking system. , 1987, Genes & development.

[19]  J. Trojanowski,et al.  Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[20]  J W Griffin,et al.  Neurofilament gene expression: a major determinant of axonal caliber. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[21]  V. Lee,et al.  Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls. , 1987, Laboratory investigation; a journal of technical methods and pathology.

[22]  F. Grosveld,et al.  Cloning and developmental expression of the murine neurofilament gene family. , 1986, Brain research.

[23]  W. Schlaepfer,et al.  Clustering of phosphorylated amino acid residues in neurofilament proteins as revealed by 31P NMR. , 1986, Biochemistry.

[24]  R. Radtke,et al.  Abnormal sensory evoked potentials in amyotrophic lateral sclerosis , 1986, Neurology.

[25]  J. Goldman,et al.  Cytoskeletal protein abnormalities in neurodegenerative diseases , 1986, Annals of neurology.

[26]  J W Griffin,et al.  Changes in neurofilament transport coincide temporally with alterations in the caliber of axons in regenerating motor fibers , 1985, The Journal of cell biology.

[27]  D. Price,et al.  Aluminum intoxication: a disorder of neurofilament transport in motor neurons , 1985, Brain Research.

[28]  W. Schlaepfer,et al.  The structure, biochemical properties, and immunogenicity of neurofilament peripheral regions are determined by phosphorylation state. , 1985, The Journal of biological chemistry.

[29]  D. Gajdusek.  Hypothesis: interference with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the central nervous system. , 1985, The New England journal of medicine.

[30]  A. Hirano,et al.  Fine Structural Observations of Neurofilamentous Changes in Amyotrophic Lateral Sclerosis , 1984, Journal of neuropathology and experimental neurology.

[31]  D. Anthony,et al.  In vitro evidence that covalent crosslinking of neurofilaments occurs in gamma-diketone neuropathy. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[32]  J W Griffin,et al.  Control of axonal caliber by neurofilament transport , 1984, The Journal of cell biology.

[33]  N. Hirokawa,et al.  Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton , 1984, Journal of Cell Biology.

[34]  A. Bizzi,et al.  Aluminum effect on slow axonal transport: a novel impairment of neurofilament transport , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[35]  E. Gardner,et al.  Formation of 10‐nanometer filaments from the 150k‐dalton neurofilament protein in vitro , 1984, Journal of neuroscience research.

[36]  M. Willard,et al.  Modulations of neurofilament axonal transport during the development of rabbit retinal ganglion cells , 1983, Cell.

[37]  L. Sternberger,et al.  Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[38]  J. Julien,et al.  The distribution of phosphorylation sites among identified proteolytic fragments of mammalian neurofilaments. , 1983, The Journal of biological chemistry.

[39]  H. Mitsumoto,et al.  Murine motor neuron disease (the wobbler mouse): degeneration and regeneration of the lower motor neuron. , 1982, Brain : a journal of neurology.

[40]  J. Julien,et al.  Multiple phosphorylation sites in mammalian neurofilament polypeptides. , 1982, The Journal of biological chemistry.

[41]  G. Shaw,et al.  Differential expression of neurofilament triplet proteins in brain development , 1982, Nature.

[42]  R. Liem,et al.  Purification of individual components of the neurofilament triplet: filament assembly from the 70 000-dalton subunit. , 1982, Biochemistry.

[43]  P. Averback,et al.  Regular involvement of Clarke's nucleus in sporadic amyotrophic lateral sclerosis. , 1982, Archives of neurology.

[44]  P. Dyck,et al.  Morphometric Comparison of the Vulnerability of Peripheral Motor and Sensory Neurons in Amyotrophic Lateral Sclerosis , 1981, Journal of neuropathology and experimental neurology.

[45]  R. Palmiter,et al.  Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs , 1981, Cell.

[46]  K. Weber,et al.  Self-assembly in Vitro of the 68,000 molecular weight component of the mammalian neurofilament triplet proteins into intermediate-sized filaments. , 1981, Journal of molecular biology.

[47]  F. Sanger,et al.  Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. , 1980, Journal of molecular biology.

[48]  W. Rutter,et al.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. , 1979, Biochemistry.

[49]  M. Shelanski,et al.  Intermediate filaments in nervous tissues , 1978, The Journal of cell biology.

[50]  D. Price,et al.  Slow axonal transport of neurofilament proteins: impairment of beta,beta'-iminodipropionitrile administration. , 1978, Science.

[51]  R. Lasek,et al.  The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons , 1975, The Journal of cell biology.

[52]  J. Andrews.  THE FINE STRUCTURE OF THE CERVICAL SPINAL CORD, VENTRAL ROOT AND BRACHIAL NERVES IN THE WOBBLER (wr) MOUSE , 1975, Journal of neuropathology and experimental neurology.

[53]  F. Andermann,et al.  Giant axonal neuropathy. A clinically and morphologically distinct neurological disease. , 1974, Archives of neurology.

[54]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[55]  S. Carpenter.  Proximal axonal enlargement in motor neuron disease , 1968, Neurology.