Telecardiology improves quality of diagnosis and reduces delay to treatment in elderly patients with acute myocardial infarction and atypical presentation

Aim To assess whether telemedicine technology applied to public emergency healthcare system improves overall quality of home diagnosis in case of acute myocardial infarction among elderly patients, often characterized by higher rates of atypical presentation. Methods About 27 841 patients from Apulia (Italy) who called public emergency healthcare number ‘118’ underwent home ECG evaluation. Data were transmitted with a mobile telephone support to a telecardiology ‘hub’ active continuously (24/7). Data from elderly patients (>70 years) were compared with younger ones. Results Thirty-nine percent of patients complained of chest (or epigastric) pain; ST elevation acute myocardial infarction (STEMI) was diagnosed in 1.9% of patients enrolled; 50.2% of patients with STEMI were above 70 years of age. Among STEMI patients older than 70 years, atypical presentation was detected in 32% [95% confidence interval (CI): 26.8–38.1] of patients (vs. 11% 95% CI: 7.8–15.5, P<0.001). Rate of atypical STEMI presentation, immediately diagnosed, thanks to telecardiology, rose up from 9.2% (95% CI: 5–17%) in the class of age 60–69 years to 25.6% (95% CI: 20–35%) in the class of age 70–79 years, to 35.2% (95% CI: 26–45%) in the class 80–89, and to 46.1% (95% CI: 26–67%) in the class greater than 89 years of age (P<0.01 in all cases). Number needed to treat (to avoid a single missed STEMI diagnosis) was 9.4 (95% CI: 6.4–12.9) for patients younger than 70 years versus 3.1 (95% CI: 2.6–3.7) among those older than 70 years (P<0.001).

[1]  D. Eterović,et al.  Symptom presentation of acute myocardial infarction: influence of sex, age, and risk factors. , 2002, American heart journal.

[2]  J P Ornato,et al.  Prevalence, clinical characteristics, and mortality among patients with myocardial infarction presenting without chest pain. , 2000, JAMA.

[3]  Elliott M. Antman,et al.  Time Delay to Treatment and Mortality in Primary Angioplasty for Acute Myocardial Infarction: Every Minute of Delay Counts , 2004, Circulation.

[4]  O. Faergeman,et al.  Living alone and atypical clinical presentation are associated with higher mortality in patients with all components of the acute coronary syndrome , 2007, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[5]  C. Fisch The clinical electrocardiogram: Sensitivity and specificity , 1997 .

[6]  E F Cook,et al.  Sensitivity of routine clinical criteria for diagnosing myocardial infarction within 24 hours of hospitalization. , 1987, Annals of internal medicine.

[7]  Simon Capewell,et al.  Heart failure in a cold climate. Seasonal variation in heart failure-related morbidity and mortality. , 2002, Journal of the American College of Cardiology.

[8]  J. Fisher,et al.  Predictors of delay in presentation to the ED in patients with suspected acute coronary syndromes. , 2003, The American journal of emergency medicine.

[9]  Harlan M Krumholz,et al.  Times to Treatment in Transfer Patients Undergoing Primary Percutaneous Coronary Intervention in the United States: National Registry of Myocardial Infarction (NRMI)-3/4 Analysis , 2005, Circulation.

[10]  J. Madias,et al.  Correlates and in-hospital outcome of painless presentation of acute myocardial infarction: a prospective study of a consecutive series of patients admitted to the coronary care unit. , 1995, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

[11]  A. Branzi,et al.  Clinical impact of direct referral to primary percutaneous coronary intervention following pre-hospital diagnosis of ST-elevation myocardial infarction. , 2006, European heart journal.

[12]  Harlan M Krumholz,et al.  The pre-hospital electrocardiogram and time to reperfusion in patients with acute myocardial infarction, 2000-2002: findings from the National Registry of Myocardial Infarction-4. , 2006, Journal of the American College of Cardiology.

[13]  N. Brunetti,et al.  Telecardiology applied to a region-wide public emergency health-care service , 2009, Journal of Thrombosis and Thrombolysis.

[14]  V. Zarubaev,et al.  Clinical Research , 2022 .

[15]  E. Antman,et al.  Combination reperfusion therapy with abciximab and reduced dose reteplase: results from TIMI 14. The Thrombolysis in Myocardial Infarction (TIMI) 14 Investigators. , 2000, European heart journal.

[16]  Harlan M Krumholz,et al.  Strategies for reducing the door-to-balloon time in acute myocardial infarction. , 2006, The New England journal of medicine.

[17]  A. Hall,et al.  Poor prognosis of patients presenting with symptomatic myocardial infarction but without chest pain , 2001, Heart.

[18]  A. Go,et al.  Older emergency department patients with acute myocardial infarction receive lower quality of care than younger patients. , 2005, Annals of emergency medicine.

[19]  F. Berthier,et al.  Seasonal variation in chronic heart failure hospitalizations and mortality in France. , 1999, Circulation.

[20]  T. Quinn,et al.  Reduction of treatment delay in patients with ST-elevation myocardial infarction: impact of pre-hospital diagnosis and direct referral to primary percutaneous intervention. , 2005, European heart journal.

[21]  A. Barsotti,et al.  Nine years' experience of telecardiology in primary care , 2004, Journal of telemedicine and telecare.

[22]  J. Gore,et al.  Seasonal distribution of acute myocardial infarction in the second National Registry of Myocardial Infarction. , 1998, Journal of the American College of Cardiology.

[23]  P. Touboul,et al.  Impact of Time to Treatment on Mortality After Prehospital Fibrinolysis or Primary Angioplasty: Data From the CAPTIM Randomized Clinical Trial , 2003, Circulation.

[24]  N. Fowler,et al.  The Electrocardiographic Pattern of Right Ventricular Hypertrophy in Mitral Valve Disease , 1955, Circulation.

[25]  R. Califf,et al.  Relationship between delay in performing direct coronary angioplasty and early clinical outcome in patients with acute myocardial infarction: results from the global use of strategies to open occluded arteries in Acute Coronary Syndromes (GUSTO-IIb) trial. , 1999, Circulation.

[26]  P. Palatini,et al.  Clinical features associated with pre-hospital time delay in acute myocardial infarction. , 2001, Italian heart journal : official journal of the Italian Federation of Cardiology.

[27]  J S Alpert,et al.  Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. , 2000, Journal of the American College of Cardiology.

[28]  H. Krumholz,et al.  Effects of age on the quality of care provided to older patients with acute myocardial infarction. , 2003, The American journal of medicine.

[29]  M. Kohn,et al.  Presenting complaint among patients with myocardial infarction who present to an urban, public hospital emergency department. , 2002, Annals of emergency medicine.

[30]  B. Maier,et al.  Present treatment of acute myocardial infarction in patients over 75 years , 2006, Clinical Research in Cardiology.