Analysis of Receiver Covered by Heterogeneous Receptors in Molecular Communications

This paper analyzes the channel impulse response of an absorbing receiver (RX) covered by multiple non-overlapping receptors with different sizes and arbitrary locations in a molecular communication system. In this system, a point transmitter (TX) is assumed to be uniformly located on a virtual sphere at a fixed distance from the RX. Considering molecule degradation during the propagation from the TX to the RX, the expected molecule hitting rate at the RX over varying locations of the TX is analyzed as a function of the size and location of each receptor. Notably, this analytical result is applicable for different numbers, sizes, and locations of receptors, and its accuracy is demonstrated via particle-based simulations. Numerical results show that (i) the expected number of absorbed molecules at the RX increases with an increasing number of receptors, when the total area of receptors on the RX surface is fixed, and (ii) evenly distributed receptors lead to the largest expected number of absorbed molecules.

[1]  T. Duke,et al.  Equilibrium mechanisms of receptor clustering. , 2009, Progress in biophysics and molecular biology.

[2]  Vahid Jamali,et al.  Channel Modeling for Diffusive Molecular Communication—A Tutorial Review , 2018, Proceedings of the IEEE.

[3]  Tuna Tugcu,et al.  Effect of Degradation in Molecular Communication: Impairment or Enhancement? , 2014, IEEE Transactions on Molecular, Biological and Multi-Scale Communications.

[4]  Robert Schober,et al.  Comprehensive Reactive Receiver Modeling for Diffusive Molecular Communication Systems: Reversible Binding, Molecule Degradation, and Finite Number of Receptors , 2016, IEEE Transactions on NanoBioscience.

[5]  H. Birkan Yilmaz,et al.  Molecular Signal Modeling of a Partially Counting Absorbing Spherical Receiver , 2017, IEEE Transactions on Communications.

[6]  Hui Li,et al.  Expected Received Signal in Diffusive Molecular Communication With Finite Binding Receptors , 2020, IEEE Communications Letters.

[7]  Nan Yang,et al.  Membrane Fusion-Based Transmitter Design for Molecular Communication Systems , 2020, ICC 2021 - IEEE International Conference on Communications.

[8]  A. Lander,et al.  How Cells Know Where They Are , 2013, Science.

[9]  Robert Schober,et al.  Saturating Receiver and Receptor Competition in Synaptic DMC: Deterministic and Statistical Signal Models , 2021, IEEE Transactions on NanoBioscience.

[10]  Tuna Tugcu,et al.  Three-Dimensional Channel Characteristics for Molecular Communications With an Absorbing Receiver , 2014, IEEE Communications Letters.

[11]  R. Chang Physical Chemistry for the Biosciences , 2005 .

[12]  Alan E. Lindsay,et al.  First Passage Statistics for the Capture of a Brownian Particle by a Structured Spherical Target with Multiple Surface Traps , 2017, Multiscale Model. Simul..

[13]  Álvaro González Measurement of Areas on a Sphere Using Fibonacci and Latitude–Longitude Lattices , 2009, 0912.4540.

[14]  H. Berg Random Walks in Biology , 2018 .

[15]  Tuna Tugcu,et al.  Effect of Receptor Density and Size on Signal Reception in Molecular Communication via Diffusion With an Absorbing Receiver , 2014, IEEE Communications Letters.

[16]  I. Guryanov,et al.  Receptor-ligand interactions: Advanced biomedical applications. , 2016, Materials science & engineering. C, Materials for biological applications.

[17]  A. Berezhkovskii,et al.  Boundary homogenization for a sphere with an absorbing cap of arbitrary size. , 2016, The Journal of chemical physics.

[18]  H. Berg,et al.  Physics of chemoreception. , 1977, Biophysical journal.

[19]  Andrew W. Eckford,et al.  A Comprehensive Survey of Recent Advancements in Molecular Communication , 2014, IEEE Communications Surveys & Tutorials.