The effects of preoperative oral pregabalin and perioperative intravenous lidocaine infusion on postoperative morphine requirement in patients undergoing laparatomy

For the treatment of postoperative pain, multimodal analgesia can reduce the side effects and required dose of opioids by combining drugs and methods with different modes of action. This study evaluated the efficacy of preoperative oral pregabalin and perioperative intravenous lidocaine in patients undergoing laparotomy.

[1]  Nirmal Singh,et al.  Pregabalin in Neuropathic Pain: Evidences and Possible Mechanisms , 2014, Current neuropharmacology.

[2]  P. Hensel,et al.  Multimodal analgesia reduces narcotic requirements and antiemetic rescue medication in laparoscopic Roux-en-Y gastric bypass surgery. , 2013, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

[3]  S. Mackey,et al.  Perioperative Gabapentinoids: Choice of Agent, Dose, Timing, and Effects on Chronic Postsurgical Pain , 2013, Anesthesiology.

[4]  A. Schulze-Bonhage Pharmacokinetic and pharmacodynamic profile of pregabalin and its role in the treatment of epilepsy , 2013, Expert opinion on drug metabolism & toxicology.

[5]  A. Weinbroum Non-opioid IV adjuvants in the perioperative period: pharmacological and clinical aspects of ketamine and gabapentinoids. , 2012, Pharmacological research.

[6]  E. Eisenberg,et al.  Antiepileptic Drugs in the Treatment of Neuropathic Pain , 2012, Drugs.

[7]  C. Woolf Central sensitization: Implications for the diagnosis and treatment of pain , 2011, PAIN.

[8]  J. Maza,et al.  Analgesic Effects of a Single Preoperative Dose of Pregabalin after Laparoscopic Sleeve Gastrectomy , 2010, Obesity surgery.

[9]  P. Moore,et al.  Local anesthetics: pharmacology and toxicity. , 2010, Dental clinics of North America.

[10]  J. Chelly,et al.  Efficacy and safety of pregabalin in the treatment of postoperative pain following inguinal herniorrhaphy: 14AP4–7 , 2010 .

[11]  M. Güleç,et al.  [Is postoperative pain only a nociceptive pain?]. , 2010, Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology.

[12]  R. Sawyer,et al.  Intravenous Lidocaine Is as Effective as Epidural Bupivacaine in Reducing Ileus Duration, Hospital Stay, and Pain After Open Colon Resection: A Randomized Clinical Trial , 2009, Regional Anesthesia & Pain Medicine.

[13]  A. Agarwal,et al.  Complications And Controversies Of Regional Anaesthesia: A Review , 2009, Indian journal of anaesthesia.

[14]  M. Beaussier,et al.  Meta‐analysis of intravenous lidocaine and postoperative recovery after abdominal surgery , 2008, The British journal of surgery.

[15]  U. Singh,et al.  Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy. , 2008, British journal of anaesthesia.

[16]  M. Rogawski,et al.  New molecular targets for antiepileptic drugs: α2δ, SV2A, and Kv7/KCNQ/M potassium channels , 2008 .

[17]  O. Mathiesen,et al.  Pregabalin and dexamethasone for postoperative pain control: a randomized controlled study in hip arthroplasty. , 2008, British journal of anaesthesia.

[18]  K. Korttila,et al.  Premedication with pregabalin 75 or 150 mg with ibuprofen to control pain after day-case gynaecological laparoscopic surgery. , 2008, British journal of anaesthesia.

[19]  K. Korttila,et al.  A randomized controlled trial of perioperative administration of pregabalin for pain after laparoscopic hysterectomy , 2008, Pain.

[20]  M. Rogawski,et al.  New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels. , 2008, Current Neurology and Neuroscience Reports.

[21]  D. Doherty,et al.  A Randomized, Placebo-Controlled Trial of Preoperative Oral Pregabalin for Postoperative Pain Relief After Minor Gynecological Surgery , 2007, Anesthesia and analgesia.

[22]  H. Friess,et al.  Systemic Lidocaine Shortens Length of Hospital Stay After Colorectal Surgery: A Double-blinded, Randomized, Placebo-controlled Trial , 2007, Annals of surgery.

[23]  S. Pyati,et al.  Perioperative Pain Management , 2007, CNS drugs.

[24]  M. Hansen,et al.  The effect of gabapentin on post‐operative pain following tonsillectomy in adults , 2006, Acta anaesthesiologica Scandinavica.

[25]  I. Gilron Review article: The role of anticonvulsant drugs in postoperative pain management: a bench-to-bedside perspective , 2006, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[26]  Siva Yogasakaran,et al.  Acute neuropathic pain after surgery: Are we treating them early/late? , 2005 .

[27]  R. Sittl,et al.  Perioperative Intravenous Lidocaine Has Preventive Effects on Postoperative Pain and Morphine Consumption After Major Abdominal Surgery , 2004, Anesthesia and analgesia.

[28]  S. Arroyo,et al.  Pregabalin Add‐on Treatment: A Randomized, Double‐blind, Placebo‐controlled, Dose–Response Study in Adults with Partial Seizures , 2004, Epilepsia.

[29]  S. Schug Is neuropathic pain an acute problem , 2002 .

[30]  M. Hollmann,et al.  Local anesthetics and the inflammatory response: a new therapeutic indication? , 2000, Anesthesiology.

[31]  P. Lumb,et al.  Intravenous Lidocaine Speeds the Return of Bowel Function, Decreases Postoperative Pain, and Shortens Hospital Stay in Patients Undergoing Radical Retropubic Prostatectomy , 1998, Anesthesia and analgesia.

[32]  T. Yaksh,et al.  Concentration‐effect Relations for Intravenous Lidocaine Infusions in Human Volunteers: Effects on Acute Sensory Thresholds and Capsaicin‐evoked Hyperpathia , 1997, Anesthesiology.