THE EFFECT OF CALOTROPIS GIGANTEA LEAF EXTRACT ON GROWTH CONTROL OF STRUVITE CRYSTALS

1Department of Chemistry, CRD, PRIST University, Vallam, Tanjavur-613403, India. 2Department of Chemistry, St. Joseph’s College, Tiruchirappalli-620002, India. ---------------------------------------------------------------***------------------------------------------------------------------ABSTRACT: Throughout the world, a large number of people suffering from urinary stone problem and upto 15% people are affected by kidney stones at some point in their life. The stone comprise the composition of calcium phosphate, calcium oxalate, uric acid and magnesium ammonium phosphate (Struvite crystals). There are many attempts are under practice to reduce the growth of Struvite crystals by natural resources, and as a consequence, we planned to utilize Calotropis gigantea, commonly known as Yercum or Madar, belongs to the family Asclepiadaceae, for this purpose. Calotropis gingantea is widely distributed in eastern and southern parts of India, and it holds various biological applications in its credit. Based on the reports on various components from various parts of the plant, the present study focused on inhibitory effect of the methanolic extract of Calotropis gingantea leaves on the growth of Struvite crystals.

[1]  V. Soni,et al.  AN OVERVIEW ON POTENT INDIGENOUS HERBS FOR URINARY TRACT INFIRMITY: UROLITHIASIS , 2012 .

[2]  A. Saluja,et al.  ISOLATION OF STIGMASTEROL AND β­SITOSTEROL FROM PETROLEUM ETHER EXTRACT OF AERIAL PARTS OF AGERATUM CONYZOIDES (ASTERACEAE) , 2011 .

[3]  S. Sutthivaiyakit,et al.  Cytotoxic cardenolides from the leaves of Calotropis gigantea. , 2010, Chemical & pharmaceutical bulletin.

[4]  S. Bari,et al.  Isolation of Lupeol, Stigmasterol and Campesterol from Petroleum Ether Extract of Woody Stem of Wrightia tinctoria , 2010 .

[5]  A. Vaidya,et al.  Growth inhibition of Struvite crystals in the presence of herbal extract Commiphora wightii , 2009, Journal of materials science. Materials in medicine.

[6]  H. Dai,et al.  A New Cytotoxic Pregnanone from Calotropis gigantea , 2008, Molecules.

[7]  Ahmed Bensatal,et al.  Inhibition of crystallization of calcium oxalate by the extraction of Tamarix gallica L , 2008, Urological Research.

[8]  E. Haque,et al.  Triterpenoids from the Stem Bark of Crataeva nurvala , 2008 .

[9]  C. K. Chauhan,et al.  Growth inhibition of Struvite crystals in the presence of juice of Citrus medica Linn. , 2008, Urological Research.

[10]  P. Varalakshmi,et al.  Antiurolithic effect of lupeol and lupeol linoleate in experimental hyperoxaluria. , 2008, Journal of natural products.

[11]  S. Ghalem,et al.  Inhibition of calcium oxalate monohydrate crystal growth using Algerian medicinal plants , 2008 .

[12]  M. Rahman,et al.  Isolation of stigmasterol and beta-sitosterol from methanolic extract of root bark of Calotropis gigantea (Linn). , 2007, Pakistan journal of biological sciences : PJBS.

[13]  P. Hamrapurkar,et al.  HPTLC Determination of Stigmasterol and Tocopherol Acetate in Leptadenia reticulata and in its Formulation , 2007, JPC – Journal of Planar Chromatography – Modern TLC.

[14]  A. Pathak,et al.  CNS activity of Calotropis gigantea roots. , 2006, Journal of ethnopharmacology.

[15]  A. Vaidya,et al.  Herbal extracts of Tribulus terrestris and Bergenia ligulata inhibit growth of calcium oxalate monohydrate crystals in vitro , 2005 .

[16]  T. Zajaczkowski,et al.  The treatment of bilateral staghorn calculi of the didneys , 1973, International Urology and Nephrology.

[17]  A. Ziyyat,et al.  Effect of aqueous extract from Herniaria hirsuta L. on experimentally nephrolithiasic rats. , 2004, Journal of ethnopharmacology.

[18]  S. Ghalem,et al.  Effect of Herbal Extracts of Tetraclinis Articulata and Chamaerops Humilis on Calcium Oxalate Crystals in Vitro , 2004 .

[19]  H. Chitme,et al.  Studies on anti-diarrhoeal activity of Calotropis gigantea R.Br. in experimental animals. , 2004, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[20]  C. Tandon,et al.  Role of Biomolecules from human renal stone matrix on COM crystal growth , 2000, Molecular and Cellular Biochemistry.

[21]  M. Gupta,et al.  Determination of betulin in Grewia tiliaefolia by HPTLC. , 2004, Journal of separation science.

[22]  M. Saraga,et al.  Pediatric urolithiasis in Croatia. , 2003, Collegium antropologicum.

[23]  B. Suresh,et al.  In vitro cytotoxic properties of Grewia tiliaefolia bark and lupeol , 2003 .

[24]  K. Naber,et al.  [Infection-induced urinary stones]. , 2003, Der Urologe. Ausg. A.

[25]  H. Kuveždić,et al.  ESWL treatment of urinary stones in children--the overview of 14 years of experience. , 2003, Collegium antropologicum.

[26]  P. Varalakshmi,et al.  Control of urinary risk factors of stones by betulin and lupeol in experimental hyperoxaluria. , 2000, Fitoterapia.

[27]  A. Hesse,et al.  Causes of phosphate stone formation and the importance of metaphylaxis by urinary acidification: a review , 1999, World Journal of Urology.

[28]  D. Polzin,et al.  Canine and feline nephrolithiasis. Epidemiology, detection, and management. , 1999, The Veterinary clinics of North America. Small animal practice.

[29]  B. Dhawan,et al.  Antiurolithiatic activity of lupeol, the active constituent isolated from Crateva nurvala , 1994 .

[30]  W. Grzeszczak,et al.  [Pathogenesis and treatment of kidney stones]. , 1994, Wiadomosci lekarskie.

[31]  S. Mahato,et al.  Flavonol glycosides from Calotropis gigantea. , 1992, Phytochemistry.

[32]  N. K. Sinha,et al.  Comparative studies on calotropins DI and DII from the latex of Calotropis gigantea. , 1984, Archives of biochemistry and biophysics.

[33]  D. P. Griffith.  Struvite stones. , 1978, Kidney international.

[34]  J. Blandy,et al.  The fate of the unoperated staghorn calculus. , 1973, British journal of urology.

[35]  J. Priestley,et al.  Branched renal calculi. , 1949, The Journal of urology.